Neoplasms

All Conditions

Digestive System Diseases

Symptoms and General Pathology

Rare Diseases

Carcinoma

Adenocarcinoma

Stomach Neoplasms

Carcinogenesis

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Stomach Diseases

Stomach Cancer

Antineoplastic Agents

All Drugs and Chemicals

Paclitaxel

Albumin-Bound Paclitaxel

Cisplatin

Chemo1 x 2 followed by ChemRT followed by Surgery followed by Chemo2 x 2

Surgery followed by Chemo1 x 2 followed by ChemRT followed by Chemo2 x 2

Chemotherapy 1:

First 2 courses of chemotherapy with the Capacitabine /cisplatin/ combination.Capacitabine1 g/me2 day 1 to 14. Cisplatin will be given at 20 mg/m2 as a one-hour bolus on day1-5.

Chemoradiotherapy:

At the end of the second 21 days of chemotherapy and one week of rest (day 57), a total of 45 Gy(1.8 Gyfx/d) of radiotherapy will be given with concurrent capacitabine 625 mg/m2 and weekly Taxol 45mg/m2 over 3 hours for 5 weeks.

Chemotherapy2:

Four to five weeks after chemoradiotherapy, Restaged and surgical resection, a D2 resection is encouraged. Peritoneal cytology will be obtained. The J-tube will be left in for at least 8 weeks after surgery to supplement patient's nutrition.

2nd courses of chemotherapy with the Capacitabine. Capacitabine1 g/me2 day 1 to 14. Chemotherapy will be repeated beginning on Day 29.

Arm 1 pre-operative chemoradiation

Surgical resection, a D2 resection is encouraged.

Chemotherapy 1:

All patients will first receive two courses of chemotherapy with the Capacitabin /cisplatin/ combination.Capacitabine1 g/me2 day 1 to 14. Cisplatin will be given at 20 mg/m2 as a bolus on day1-5. Chemotherapywill be repeated beginning on Day 22.

Chemoradiotherapy:

At the end of the second 21 days of chemotherapy and one week of rest (day 57), a total of 45 Gy(1.8 Gyfx/d) of radiotherapy will be given with concurrent capacitabine 625 mg/m2 and weekly Taxol 45mg/m2 over 3 hours for 5 weeks.

Chemotherapy2:

2nd courses of chemotherapy with the Capacitabin. Capacitabine 1g/me2 day 1 to 14. Chemotherapy will be repeated beginning on Day 29

Arm 2 post operative chemoradiation

Qian Peng, MD PhD

lili deng, MD

min wei, MD

Ming Zeng, MD PhD

Hongwei Zhang, MD PhD

Based upon RTOG 9904, this study is to investigate the role of preoperative chemo and chemoradiation for locally advanced gastric cancer.

Preoperative Stomach Cancer Induction Chemotherapy and Radiation Therapy

A Phase III Trial of Preoperative or Postoperative Chemoradiation Therapy for Potentially Resectable Adenocarcinoma of Stomach Cancer

Xijing Hospital

Sichuan Provincial People's Hospital

Director of Cancer Center

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Preoperative Stomach Cancer Induction Chemotherapy and Radiation Therapy	NCT03223740	Locally Advance...	Arm 1 pre-opera... Arm 2 post oper...	18 Years - 75 Years	Sichuan Provincial People's Hospital
Preoperative Stomach Cancer Induction Chemotherapy and Radiation Therapy	NCT03223740	Locally Advance...	Arm 1 pre-opera... Arm 2 post oper...	18 Years - 75 Years	Sichuan Provincial People's Hospital

Spots Global Cancer Trial Database for arm 2 post operative chemoradiation