Neoplasms

Digestive System Diseases

All Conditions

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Anti-Inflammatory Agents

Antineoplastic Agents

Antiemetics

Gastrointestinal Agents

All Drugs and Chemicals

Central Nervous System Depressants

Adjuvants, Anesthesia

Analgesics

Dexamethasone

Bupivacaine

Fentanyl

Anesthetics

Propofol

Isoflurane

Dexamethasone acetate

Atracurium

Hypnotics and Sedatives

Anesthetics, Intravenous

Anesthetics, General

Analgesics, Opioid

Narcotics

Neuromuscular Nondepolarizing Agents

Neuromuscular Blocking Agents

Cholinergic Antagonists

Cholinergic Agents

Neurotransmitter Agents

Patients will receive bilateral ultrasound-guided erector spinae plane block as an adjuvant analgesic technique

Patients will receive bilateral ultrasound-guided quadratus lumborum block as an adjuvant analgesic technique

For each side, the eighth thoracic transverse process will be identified by a linear US transducer (HFL38_10-5 MHz), puncture will be performed in the plane in the craniocaudal direction until the needle contacts the transverse process, and 20 ml of bupivacaine 0.25% and 4 mg dexamethasone will be injected visualizing the hydrodissection. After 30 minutes, the degree of sensory block in the trunk will be assessed by the pinprick test and any undesirable motor weakness will be recorded as a side effect.

Erector spinae plane block

For each side, shamrock sign with three leaves (psoas major muscle anteriorly, the erector spinae muscle posteriorly and the quadratus lumborum muscle adherent to the apex of the transverse process of the L4 vertebral body) will be identified by a curved array US transducer (6-2MHz), puncture will be performed in-plane, the needle will be advanced through the quadratus lumborum muscle penetrating the ventral proper fascia of the quadratus lumborum muscle, and 20 mL of bupivacaine 0.25% and 4 mg dexamethasone will be injected in that space visualizing the hydrodissection. After 30 minutes, the degree of sensory block in the trunk will be assessed by the pinprick test and any undesired motor weakness will be recorded as a side effect

Quadratus lumborum block

Fentanyl NCS

Atracurium Injectable Product

Endotracheal intubation

Inhalational isoflurane in oxygen/air mixture

Anesthesia Maintenance

atracurium boluses (0.2 mg/Kg/20 minutes) will be used for maintenance of general anesthesia

Muscle Relaxation

Amer A Attieh, MD

Mohammed A Ghanem, MD

Colorectal cancer is the third most common cancer worldwide. These patients usually undergo open surgical resection of cancer under general anaesthesia.

The aim of this study is to detect whether the Erector spinae plan block or Quadratus lumborum block will provide the most ideal analgesia for these patients. Erector spinae plan block is a novel analgesic technique that provides both visceral and somatic analgesia due to its communication with the paravertebral space. Quadratus lumborum block is a truncal nerve block usually used for intra-abdominal surgeries. Ultrasound guidance increases the accuracy and safety of both techniques. A local anaesthetic mixture of Bupivacaine 0.25% and dexamethasone will be used for both techniques.

Erector spinae plane block and quadratus lumborum block are analgesic techniques suitable for open colorectal cancer surgeries. postoperative pain score, serum levels of biomarkers of stress (cortisol and CRP), primary hemodynamics, time to first rescue analgesic request, the total amount of rescue analgesic consumption and postoperative nausea and vomiting are the parameters of comparison between both techniques.

Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block

A Comparative Study of Analgesic Effect of Ultrasound Guided Erector Spinae Plane Block Versus Quadratus Lumborum Block for Open Colorectal Cancer Surgeries

The intensity of pain indicated by a segmented numeric scale in which a respondent selects a whole number (0-100 integers) that best reflects his/her pain as 0-30 for mild pain, 30-60 for moderate pain and 60-100 for sever pain

The pressure in the arteries during contraction of the heart

: The average pressure in the arteries during one cardiac cycle. It is a better indicator for vital organs' perfusion than the systolic pressure

The number of heart beats per minute. A lower heart rate at rest implies a more efficient heart function, better cardiovascular fitness and less stress

The time elapsed from termination of performing each block till the patient's request for analgesia. It resembles the duration of analgesia

An estimate of oxygenated hemoglobin concentration in blood. It is measured by pulse oximeter device

The total amount of morphine consumed by the patient for pain relief over the 48 hours postoperatively

Postoperative Nausea and Vomiting Intensity Scale: A scale that evaluates postoperative nausea and vomiting. It equals severity of nausea (1=mild, 2= moderate, 3= sever) x pattern of nausea (1=varying, 2= constant) x duration of nausea (in hours). At any time, if it is \< 50 or vomiting occurs once or twice, it is clinically unimportant (good outcome). If it is ≥50 or vomiting occurs 3 or more times, it is clinically important (bad outcome). The sum of all values will quantify the entire period of the study.

A steroid hormone secreted by adrenal cortex in response to stress and hypoglycemia

A protein synthetized by hepatocytes in response to systemic inflammation or tissue damage

Spots Global Cancer Trial Database for atracurium injectable product