Neoplasms

Digestive System Diseases

All Conditions

Rare Diseases

Stomach Neoplasms

Stomach Cancer

BAY1143572 will be administered from cycle 1, day 1 (C1D1) onwards once daily continuously

BAY1143572 will be administered from C1D1 in a 3 days on/4 days off schedule

BAY1143572

Bayer Study Director

The purpose of this study Part A is to determine the safety, tolerability and the pharmacokinetics of BAY1143572 in subjects with advanced malignancies, which are either refractory to or ineligible for treatment with standard agents.

The purpose of this study Part B is:

Determine the safety, tolerability, pharmacokinetics (PK) and maximum tolerated dose (MTDG-CSF) of BAY1143572 with concurrent administration of the granulocyte colony-stimulating factors (G-CSF) in an intermittent and continuous dosing schedule in subjects with advanced malignancies.

Open Label Phase I Dose Escalation Study With BAY1143572 in Patients With Advanced Cancer

An Open-label Phase I Dose-escalation Study to Characterize the Safety, Tolerability, Pharmacokinetics, and Maximum Tolerated Dose of BAY1143572 Given in a Once-daily or an Intermittent Dosing Schedule in Subjects With Advanced Malignancies

In Part A: Maximum tolerated dose (MTD) of BAY1143572 In Part B; Maximum tolerated dose ( MTD) with G-CSF of BAY114357 The MTD is defined as the highest dose that can be given such that not more than 20% of subjects experience a dose limiting toxicity (DLT) during cycle 1.

PCNA: proliferating cell nuclear Antigen mRNA: messenger ribonucleic acid

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Open Label Phase I Dose Escalation Study With BAY1143572 in Patients With Advanced Cancer	NCT01938638	Neoplasms	BAY1143572	21 Years -	Bayer
Open Label Phase I Dose Escalation Study With BAY1143572 in Patients With Advanced Cancer	NCT01938638	Neoplasms	BAY1143572	21 Years -	Bayer

Spots Global Cancer Trial Database for bay1143572

Every month we try and update this database with for bay1143572 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for bay1143572

Every month we try and update this database with for bay1143572 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for bay1143572 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.