Nutritional and Metabolic Diseases

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600ml drink which contains 18g BCAA was consumed by patients 2-4h before surgery.

600ml water was consumed by patients 2-4h before suegery.

BCAA

water

Peng Sun, MD

Hengyu Lv

Peng Sun

Postoperative insulin resistance refers to the phenomenon that the body's glucose uptake stimulated by insulin is reduced due to stress effects such as trauma or the inhibitory effect of insulin on liver glucose output is weakened after surgery.

There is a clear link between postoperative insulin resistance and poor perioperative prognosis. Therefore, exploring interventions to reduce postoperative stress insulin resistance, stabilize postoperative blood glucose, and reduce postoperative complications are clinical problems that need to be solved urgently. In recent years, research on branched-chain amino acids and metabolic diseases has become a hot spot. Studies have found that in the rat model, preoperatively given a high branched-chain amino acid diet can inhibit postoperative insulin resistance and stabilize blood glucose levels. This research plan is to try to add branched-chain amino acids before surgery to observe the occurrence of postoperative insulin resistance in patients.

Impact of Preoperative Oral Branched-chain Amino Acids on Reducing Postoperative Insulin Resistance.

A Multicenter Randomized Controlled Study of Preoperative Oral Administration of Branched-chain Amino Acids in Reducing Postoperative Insulin Resistance in Colorectal Cancer Patients

The proportion of postoperative blood glucose\>8mmol/L.Measure method：Continuous blood glucose meter.

Measured by continuous blood glucose meter

Measured by blood test. HOMA-IR = (blood glucose \[mmol/L\] × blood insulin \[μunits/mL\])/22.5.

Postoperative complications include branched-chain amino acid-related complications, surgery-related complications, and systemic complications. Postoperative complications were graded according to the Clavien-Dindo system

Huashan Hospital

Yangpu District Central Hospital Affiliated to Tongji University

Sun Peng

Executive Director of General Surgery

Ear, Nose, and Throat Diseases

Rare Diseases

Stomach Neoplasms

Deglutition Disorders

Stomach Diseases

Stomach Cancer

patients undergoing BCAA before surgery to postoperative day 30

patient not administered BCAA

Chih-Jun Lai

Older patients undergoing gastric cancer resection, at higher risk due to insufficient preoperative muscle mass, are more susceptible to SRML under surgical stress. This not only affects limb muscles but also impacts swallowing muscles, contributing to increased postoperative complications and mortality rates. Enhanced Recovery After Surgery (ERAS) has emerged as a multidisciplinary approach to facilitate postoperative recovery. This study aims to optimize oral nutrition under the ERAS model to observe its impact on SRML. BCAA is essential for skeletal muscles. However, there is limited research on the oral BCAA, whether before or after surgery, concerning SRML and its associated complications. The study entails an 18-month randomized controlled trial with 200 participants. One hundred individuals will take BCAA daily 5 to 14 days before surgery. After surgery, they can progress to a clear liquid diet around postoperative day five while continuing BCAA until 30 days postoperatively. The other one hundred participants will not receive BCAA. The study aims to investigate whether oral BCAA can reduce SRML, muscle loss, and decrease swallowing muscle strength, with observations on postoperative complications and outcomes within one year.

Surgical Related Muscle Loss (SRML) is a prevalent complication following surgery, defined by a 10 percent or more reduction in muscle mass in at least one arm and one leg muscle by the seventh day postoperatively. Older patients undergoing gastric cancer resection, at higher risk due to insufficient preoperative muscle mass, are more susceptible to SRML under surgical stress. This not only affects limb muscles but also impacts swallowing muscles, contributing to increased postoperative complications and mortality rates. Enhanced Recovery After Surgery (ERAS) has emerged as a multidisciplinary approach to facilitate postoperative recovery. This study aims to optimize oral nutrition under the ERAS model to observe its impact on SRML. BCAA is essential for skeletal muscles. However, there is limited research on the oral BCAA, whether before or after surgery, concerning SRML and its associated complications.

The investigators entails an 18-month randomized controlled trial with 200 participants. One hundred individuals will take 3160 mg of BCAA daily 14 days before surgery. After surgery, they can progress to a clear liquid diet around postoperative day five while continuing BCAA until 30 days postoperatively. The other one hundred participants will not receive BCAA. The study aims to investigate whether oral BCAA can reduce SRML, muscle loss, and decrease swallowing muscle strength, with observations on postoperative complications and outcomes within one year.

Regarding the swallowing measurement, high-resolution impedance manometry, the most accurate tool for assessing swallowing muscle strength, will be used. The ultrasound will also be used to investiagte the muscle loss. We will also investigate the genome associated BCAA study.

BCAA in Patients Undergoing Gastric Cancer Surgery

The Impact of Oral Branched-Chain Amino Acids Under Enhanced Recovery After Surgery on Reducing Postoperative Muscle Loss, Swallowing Difficulties, and Complications After Gastric Cancer Surgery: From Clinical to Precision Nutrition

examined the surgical related muscle loss occurence

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Impact of Preoperative Oral Branched-chain Amino Acids on Reducing Postoperative Insulin Resistance.	NCT05494658	Insulin Resista... Colorectal Canc...	BCAA water	50 Years - 80 Years	Shanghai Tong Ren Hospital
Impact of Preoperative Oral Branched-chain Amino Acids on Reducing Postoperative Insulin Resistance.	NCT05494658	Insulin Resista... Colorectal Canc...	BCAA water	50 Years - 80 Years	Shanghai Tong Ren Hospital
BCAA in Patients Undergoing Gastric Cancer Surgery	NCT06340399	Perioeprative M...	BCAA patient not adm...	20 Years - 90 Years	National Taiwan University Hospital

Spots Global Cancer Trial Database for bcaa

Every month we try and update this database with for bcaa cancer trials from around the world to help patients and their families find trials that might be right for them.
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Spots Global Cancer Trial Database for bcaa

Every month we try and update this database with for bcaa cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for bcaa cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.