Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Rare Diseases

Melanoma

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Nerve Tissue

Nevus, Pigmented

Nevus

Nevi and Melanomas

Skin Neoplasms

Skin Diseases

Neuroendocrine Tumor

Neuroepithelioma

Observation of real-life treatment with encorafenib and binimetinib

Encorafenib

Binimetinib

Christian A Rosé, MD

Andrea Schmidt, MSc

BERING-MELANOMA - designed as a prospective, longitudinal, non-interventional study - investigates real-world effectiveness, quality of life, safety and tolerability of encorafenib plus binimetinib in unresectable advanced or metastatic BRAF(Rapidly Accelerated Fibrosarcoma isoform B)-V600-mutant malignant melanoma after commercial availability of these two products in Germany, Austria and Switzerland. The study focusses on the documentation of the first and second line setting (i.e. after one line of prior checkpoint inhibition) by documenting patients treated according to the SmPC (Summary of Product Characteristics).

Binimetinib Plus Encorafenib Real Life Investigation of Next Generation Melanoma Treatment

Encorafenib Plus Binimetinib in Patients With Locally Advanced, Unresectable or Metastatic BRAFV600-mutated Melanoma: a Multi-centric, Multinational, Prospective, Longitudinal, Non-interventional Study in Germany, Austria and Switzerland - BERING MELANOMA

Treatment sequence prior to and after encorafenib plus binimetinib; by documenting pre-treatments with adjuvant therapy and systemic therapy in palliative setting; and by documenting subsequent systemic treatment lines after administration of encorafenib plus binimetinib

Evaluation of reason for treatment selection (efficacy, safety profile, quality of life, patients preference, physician's preference, comorbidities, other)

Further progression-free survival parameters

EORTC QLQ C-30 questionnaires (European Organisation for Research and Treatment of Cancer Quality of Life C-30 questionnaires) to assess quality of life of cancer patients; comprises 30 items, 24 of which are aggregated into nine multi-item scales, that is, five functioning scales (physical, role, cognitive, emotional and social), three symptom scales (fatigue, pain and nausea/vomiting) and one global health status scale. The remaining six single-item (dyspnoea, appetite loss, sleep disturbance, constipation, diarrhoea and the financial impact) scales assess symptoms.

WPAI questionnaires (Work Productivity and Activity Impairment questionnaires). The following questions ask about the effect of patients melanoma on the ability to work and perform regular activities.

1. Are you currently employed (working for pay)?
2. During the past seven days, how many hours did you miss from work because of problems associated with your melanoma?
3. During the past seven days, how many hours did you miss from work because of any other reason?
4. During the past seven days, how many hours did you actually work?
5. During the past seven days, how much did your melanoma affect your productivity while you were working?
6. During the past seven days, how much did your melanoma affect your ability to do your regular daily activities, other than work at a job?

CTSQ questionnaires (Cancer Therapy Satisfaction Questionnaire) to assess patients' opinions and feelings concerning their cancer therapy and associated adverse events:

1. Questions to patients thoughts about cancer therapy (IV/pills). Scale: \[Always, Most of the time, Some-times, Rarely, Never\];
2. Questions to patients satisfaction with the most recent cancer therapy (IV/pills):

   1. Scale reg. benefit: \[Much better than my expectations Somewhat better than my expectations, Met my expectations, Somewhat worse than my expectations, Much worse than my expectations\];
   2. Scale reg. side effects: \[Much better than I expected, Somewhat better than I expected, Exactly as I expected, Somewhat worse than I expected, Much worse than I expected\];
   3. Scale reg. satisfaction: \[Very satisfied, Satisfied, Neither satisfied nor dissatisfied, Dissatisfied, Very dissatisfied\];
   4. Scale reg. choice of therapy: \[Yes, definitely, Probably Yes, I don't know, Probably not, Definitely not\]

Physicians' satisfaction questionnaires (measuring Physician's Satisfaction with regard to Effictiveness and Safety, as well as Physician's Overall Treatment Satisfaction) using the following scale construct:

1. Physician's Satisfaction with regard to Efficiency
2. Physician's Satisfaction with regard to Safety
3. Physician's Overall Treatment Satisfaction

Scale:

* very dissatisfied
* dissatisfied
* moderately satisfied
* satisfied
* very satisfied

Number of patients with Adverse Events and maximum grade per patient, Adverse Drug Reactions, Adverse Drug Reactions grade 3/4, Serious Adverse Events, Serious Adverse Drug Reactions.

Influence of prognostic factors on quality of life outcome parameters

Influence of prognostic factors on effectiveness

Influence of prognostic factors on safety

From date of first treatment (encorafenib or binimetinib, whichever occurs first) until date of last treatment (encorafenib or binimetinib, whichever occurs last)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Binimetinib Plus Encorafenib Real Life Investigation of Next Generation Melanoma Treatment	NCT04045691	Melanoma Stage ... Melanoma Stage ...	Encorafenib Binimetinib	18 Years -	Pierre Fabre Pharma GmbH
Binimetinib Plus Encorafenib Real Life Investigation of Next Generation Melanoma Treatment	NCT04045691	Melanoma Stage ... Melanoma Stage ...	Encorafenib Binimetinib	18 Years -	Pierre Fabre Pharma GmbH

Spots Global Cancer Trial Database for bering

Every month we try and update this database with for bering cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for bering

Every month we try and update this database with for bering cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for bering cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.