Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Hypoxia

Uterine Cervical Neoplasms

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Cervical Diseases

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Signs and Symptoms, Respiratory

Cervical tumour biopsy during treatment. This will be used for gene expression (RNA) analysis against a hypoxia associated gene signature.

Biopsy of tumour

Multiple magnetic resonance imaging (MRI) scans before and during treatment using oxygen enhanced (OE) / tissues oxygen level dependent (TOLD) sequence

MRI scans

Anubhav Datta, MBChB, FRCR

Patients with locally advanced cervical cancer (LACC) are primarily treated with radiotherapy +/- chemotherapy however 5-year survival rates are \<60% with significant treatment toxicity. Hypoxia is a well-known radioresistant component of solid tumours such as cervical cancer and hypoxia modification therapies have demonstrated immense promise in treating such tumours. A major factor in determining a successful outcome with hypoxia modification is appropriate patient selection as it is hypoxic tumours that receive the most benefit from hypoxia modifying therapies. To date there is no validated hypoxia biomarker to stratify patients for therapy in cervical cancer in clinical use. This project offers a unique opportunity to examine both genetic and imaging biomarkers to optimise patient stratification when receiving curative radiotherapy for cervical cancer.

Biomarkers for Clinical Hypoxia Evaluation in Cervical Cancer

20 patients will undergo functional imaging (hypoxia MRI) at baseline. Following this, serial measurements will be taken on a weekly basis during the first 5 weeks of chemoradiation. The imaging and biopsy cohorts are the same.

Investigators will collect paired biopsies at diagnosis and at brachytherapy in 20 locally advanced cervical cancer patients. The imaging and biopsy cohorts are the same.

The Christie NHS Foundation Trust

University of Manchester

Clinical Research Fellow in Radiology, Principal Investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Biomarkers for Clinical Hypoxia Evaluation in Cervical Cancer	NCT05029258	Cervical Cancer	Biopsy of tumou... MRI scans	18 Years -	University of Manchester
Biomarkers for Clinical Hypoxia Evaluation in Cervical Cancer	NCT05029258	Cervical Cancer	Biopsy of tumou... MRI scans	18 Years -	University of Manchester

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