Neoplasms

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Gland and Hormone Related Diseases

Carcinoma

Thyroid Neoplasms

Thyroid Diseases

Hypothyroidism

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Endocrine System Diseases

Endocrine Gland Neoplasms

Head and Neck Neoplasms

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Herbal and Botanical

Hormones

Synthroid will be administered with 12 ounces of black coffee for a period of 6 weeks.

Synthroid will be administered with 12 ounces of coffee and 2 ounces of 2% milk for a period of 6 weeks.

Synthroid will be administered with 12 ounces of black Lipton tea for a period of 6 weeks.

Synthroid will be administered with 12 ounces of water for a period of 6 weeks.

Taking Synthroid with 12 ounces of black coffee for 6 weeks.

Black Coffee

Taking Synthroid with 12 ounces of black coffee and 2 ounces of 2% milk for a period of 6 weeks.

Coffee with Milk

Taking Synthroid with 12 ounces of black tea for a period of 6 weeks.

Black Tea

Taking Synthroid with water for a period of 6 weeks.

Water

Dorota Krajewski, MD

The purpose of this study is to evaluate whether taking thyroid hormone medication with beverages other than water, decreases absorption of the medication by the intestine. Specifically we are interested in whether coffee, coffee with milk, or black tea affects how thyroid medication is absorbed by the body. Previous studies have suggested that taking thyroid hormone with coffee may interfere with the ability to absorb thyroid medicine. Given that many patients take their thyroid medicine with beverages other than water, and specifically with coffee or tea, understanding whether and how much coffee or tea may decrease thyroid hormone absorption is important for clinical practice.

This study will help determine the safest and most effective way for adults to take their thyroid medication and will guide medical practitioners in how to counsel their patients when they prescribe thyroid hormone.

Previous studies have suggested that taking thyroid replacement therapy with coffee potentially hinders its absorption. We already know that food especially a fiber-rich diet, cholestyramine resin, aluminum containing antacids, activated charcoal, and certain herbal remedies among others interfere with the ability to absorb thyroid medicine. These findings have prompted providers to advise patients to take their levothyroxine on an empty stomach in the morning. However, many patients take their thyroid medicine with their morning cup of coffee prior to eating breakfast. A small study has shown that Italian espresso coffee can decrease the absorption of levothyroxine, but the effect of American style coffee is not known. Given that the intestinal absorption of levothyroxine can be hindered by multiple substances and coffee is the most commonly consumed beverage worldwide, it is important to investigate what effect coffee may have on thyroid hormone absorption and thyroid function tests.

Using methods similar to those used in previous studies, this study will measure thyroid function tests in approximately 10-20 subjects (18-60 years of age) over a 6 hour period of time after taking their thyroid medication with the specified study beverage for a 6 week period. Subjects will be randomized to water, black coffee, coffee with milk, and black tea as four specified study beverages, with water serving as the control beverage. Each subject will be recruited to participate with each study beverage for a 6 week period of time in a total of four consecutive 6 week periods. Blood draws will occur at the end of each 6 week period on test days 1, 2, 3, and 4. The coffee will represent the most common household coffee brand, Folgers. Thyroid function tests with each beverage will be compared to thyroid function tests with water to determine if thyroid medication absorption is impaired by coffee, coffee with milk, or tea.

This study will help determine the safest and most efficacious way for adults to take their thyroid medication and will guide medical practitioners in how to counsel their patients when they prescribe thyroid replacement therapy.

The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma

The Effect of Coffee Consumption on the Intestinal Absorption of Levothyroxine Thyroid Hormone Replacement in Patients With Thyroid Carcinoma

1. change in TSH over 6 hours
2. peak change in TSH over 6 hours

To determine if taking Synthroid for 6 weeks with each of the prescribed study beverages results in a different baseline TSH, reflecting altered absorption of levothyroxine with each particular beverage.

1. Change in total T4 over 6 hours
2. Peak change in total T4 over 6 hours
3. area under the curve (AUC) for total T4

1. Change in free T4 over 6 hours
2. Peak change in free T4 over 6 hours
3. area under the curve (AUC) for free T4

1. Change in total T3 over 6 hours
2. Peak change in total T3 over 6 hours
3. area under the curve (AUC) for total T3

Georgetown University

Medstar Health Research Institute

Respiratory Tract (Lung and Bronchial) Diseases

Lung Neoplasms

4 cups/day of green tea for 6 months; each cup is prepared by brewing 2 tea bags in 12 oz of water

Green tea

4 cups/day of black tea for 6 months; each cup is prepared by brewing 2 tea bags in 12 oz of water

Black tea

4 cups/day of placebo tea for 6 months; each cup is prepared by brewing 2 tea bags in 12 oz of water

Placebo tea

The overall objective of this study is to determine the effect of high tea consumption on biological markers of oxidative stress that mediate lung cancer risk.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma	NCT01707056	Thyroid Carcino... Hypothyroidism	Black Coffee Coffee with Mil... Black Tea Water	18 Years - 60 Years	Medstar Health Research Institute
High Tea Consumption on Smoking Related Oxidative Stress	NCT02719860	Lung Cancer Pre...	Green tea Black tea Placebo tea	40 Years - 80 Years	University of Arizona

Spots Global Cancer Trial Database for black tea

Every month we try and update this database with for black tea cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for black tea

Every month we try and update this database with for black tea cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for black tea cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.