Diseases and Abnormalities at or Before Birth

All Conditions

Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Heart and Blood Diseases

Symptoms and General Pathology

Congenital Abnormalities

Lung Neoplasms

Testicular Neoplasms

Cardiac Complexes, Premature

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Group 1 : patient with lung cancer in stage 1-2, lung cancer of all histology kind eligible for surgery

Group 2 : patient with lung cancer in stage 3-4 (no adenocarcinoma or squamous) receiving classical or targeted chemotherapy on genetic anomalies.

Group 3 control patients : carriers of non-cancerous radiological anomalies : benign nodules, cicatricial lesions, infectious or inflammatory, paired with the two other groups by age, sex or tobacco.

In order to extract RNA (LungCancerTest) and DNA (mutation, reassortment).

Blood and respiratory fluids sampling

Biopsy

Excised tissues

Christian Brambilla, Professor

The diagnosis of lung cancer is the first cause of cancer deaths for man and woman. It requires invasive procedures (at least endoscopy, transthoracic puncture, or surgery).

This study is about the set up of an innovative test for lung cancer prognosis, based on biopsies and surgical material : LungCancerTest, with the creation of a start-up in progress.

The main goal of this study is to approve the diagnostic value of the molecular signature of the 26 genes (LungCancerTest) revealed in blood and respiratory fluids among patients with lung cancer.

Study on Fluids Associated to Lung Cancer

Study on Fluids Associated to Lung Cancer, of the Ectopic Expression of Cancer Testis Gene and Mutation as Diagnostics and Prognosis Biomarkers

From plasma or respiratory fluids, with Qiagen QIAamp MinElute Virus Spin kit.

Picogreen technique (fluorimétrie) with the device Qubit 2.0 Characterization of DNA by migration on revealed agarose gel in presence of ethidium bromide

Study of DNA (mutation, reassortment) with New Generation Sequencing materiel.

From plasma or respiratory fluids, with Qiagen QIAamp MinElute Virus Spin kit.

Picogreen technique (fluorimétrie) with the device Qubit 2.0 Characterization of RNA with an Agilent chip

Study of RNA (LungCancerTest) with PCR-Array prototype to show the expression of the molecular signature (Cancer Testis genes).

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Study on Fluids Associated to Lung Cancer	NCT02853006	Lung Cancer	Blood and respi... Biopsy Excised tissues	18 Years -	University Hospital, Grenoble
Study on Fluids Associated to Lung Cancer	NCT02853006	Lung Cancer	Blood and respi... Biopsy Excised tissues	18 Years -	University Hospital, Grenoble

Spots Global Cancer Trial Database for blood and respiratory fluids sampling