Neoplasms

All Conditions

Rare Diseases

Hemangiosarcoma

Sarcoma

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Neoplasms, Vascular Tissue

Angiosarcoma of the Liver

Soft Tissue Sarcoma

Hematinics

All Drugs and Chemicals

Liver Extracts

Blood and urine collections, questionnaire and telephone interview

Blood collection and urine collection after consent of the patient

blood and urine

The patient complete the questionnaire alone at home

Questionnaire

The patient will be contacted by the CRA for a telephone interview of around one hour

Telephone interview

LE MOAL Joelle, Dr

PENEL Nicolas, MD

The purpose of this study is to test the feasibility of identifying incident cases of angiosarcoma of the liver from the network NetSarc.

The study involves a questionnaire and a one-hour telephone interview.

Consultation:

* Study proposal
* Information and collection of the patient's and/or parent's written consents
* Blood collection (10ml) and urine collection of the patient and parents if applicable
* Delivery of a specific questionnaire and a stamped envelope (with the address of the coordinator's center). If it's about a child patient or an adolescent under 18 years, 3 questionnaires will be given (1 for each parent and 1 for the child).

At home: Filling the questionnaire by the patient and/or the parents, alone at home and return to the coordinator via the given envelope.

During the study: Collect of the initial biopsies used for the hepatic angiosarcoma's diagnostic.

End of the study: Telephone interview CRA/Patient and/or parents to complete the questionnaires (around one hour). From this data will be reconstitute the residential process of the patient and parents if it's about a child or an adolescent (collection of the successive addresses).

Finally, water collections, according to a defined sampling protocol, at the tap of the different homes and places visited by the patients will be organized by the InvS in relation to the ARS within the scope of water quality controls, in order to evaluate the exposition to vinyl chloride monomer (VCM) by hydric ways.

Identification, Molecular Epidemiology Angiosarcoma of the Liver France

Feasibility of identifying incident cases of angiosarcoma of the liver (ASF) from the network NetSarc: number of sheets indicated and returned to the Promoter. 30 cases are expected, the cumulative number of incident cases will be measured over a period of 36 months

Data will be collected using a questionnaire with:

* Exhaustive search of all occupational and environmental exposures as known or suspected risk factors for ASF
* Reconstruction of residential history and haunts each case by means of a collection of successive addresses

Research suggestive of carcinogenesis related to CVM (identified in animal models and cohorts of workers exposed) biomarkers will be made by biological testing (blood and urine) adducts éthénobases kind resulting from the reaction of metabolites with CVM DNA and specific gene mutations k-ras and p53. Exposure to arsenic via the determination of Arsenic urinaire.sera sought.

The p53 and K-ras genes are also sequences from initial diagnostic biopsies.

Data will be collected using a questionnaire with:

- Assessment of the amount of vinyl chloride monomer (VCM) in successive addresses or nearby for cases without occupational exposure identified

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Identification, Molecular Epidemiology Angiosarcoma of the Liver France	NCT01786889	Angiosarcoma	blood and urine Questionnaire Telephone inter...	-	Centre Oscar Lambret
Identification, Molecular Epidemiology Angiosarcoma of the Liver France	NCT01786889	Angiosarcoma	blood and urine Questionnaire Telephone inter...	-	Centre Oscar Lambret

Spots Global Cancer Trial Database for blood and urine