Neoplasms

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Pancreatic Cyst

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Pyruvate

Participants will be diagnosed with a pancreatic cystic neoplasm deemed to be high risk and requiring surgical resection

Participants who choose to will undergo immunoPET before surgery.

89Zr-DFO-HuMab-5B1 immunoPET

Participants who choose to will undergo HP MRI before surgery.

HP MRI

Will be drawn within 6 weeks of surgery and annually as post operative care

Blood assay

Kevin Soares, MD

David Kelson, MD

David Lyden, MD

Kevin Soares, PhD

The purpose of this study is for researchers to find ways of detecting pancreatic ductal adenocarcinoma/PDAC early to avoid the invasive procedure of surgery. The study researchers think a combination of imaging and a series of blood tests may be an effective way to detect PDAC early. In this study, researchers will look at whether a combination of the following types of imaging with blood tests can detect PDAC in pancreatic cysts:

* The ImmunoPET scan (immune-positron emission tomography scan) with the imaging agent 89Zr-DFO-HuMab-5B1
* The HP MRI scan (hyperpolarized pyruvate magnetic resonance imaging scan)

A Study of Early Cancer Detection in People at High Risk of Developing Pancreatic Ductal Adenocarcinoma (PDAC)

Immuno-Positron Emission Tomography, Hyperpolarized C Pyruvate Magnetic Resonance Imaging, and Blood-Based Biomarkers for Early Detection of Pancreatic Adenocarcinoma in Patients With Intraductal Papillary Mucinous Neoplasms

• Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

Assess preliminary sensitivity and specificity if the immunoPET is able to identify the presence or absence of adenocarcinoma or high-grade dysplasia in participants who are scheduled to undergo surgical resection.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Study of Early Cancer Detection in People at High Risk of Developing Pancreatic Ductal Adenocarcinoma (PDAC)	NCT06305728	Pancreatic Cyst	89Zr-DFO-HuMab-... HP MRI Blood assay	18 Years -	Memorial Sloan Kettering Cancer Center
A Study of Early Cancer Detection in People at High Risk of Developing Pancreatic Ductal Adenocarcinoma (PDAC)	NCT06305728	Pancreatic Cyst	89Zr-DFO-HuMab-... HP MRI Blood assay	18 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for blood assay

Every month we try and update this database with for blood assay cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for blood assay

Every month we try and update this database with for blood assay cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for blood assay cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.