Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Symptoms and General Pathology

Lung Neoplasms

Genetic Predisposition to Disease

Disease Susceptibility

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Disease Attributes

Pt will have three green top tubes of blood drawn. The questionnaire will be filled out by the study subject. This may be completed at home and mailed in a provided stamped addressed envelope if the patient prefer, or obtained by phone interview with a research assistant.

Blood draw and Questionnaires

Irene Orlow, PhD

The purpose of this study is to help us better understand the cellular changes that may lead to the development of lung cancer. We want to compare people with a second primary lung cancer with those who have only a first primary lung cancer. We hope to use the information obtained in this study as the basis for future studies and will not regard the results from this study as final.

We will analyze your blood cells and DNA to measure the changes in several genes that we believe may be involved in lung cancer. We also want to evaluate the capacity for your DNA to repair itself.

* 30 ml. Blood in heparinized, green top tubes.
* Fresh tumor or normal tissue, when available.
* Tissue or cells from routine bronchoscopy, when available.

DNA Repair and Genetic Susceptibility to Lung Cancer

Memorial Sloan Kettering Cancer Center

Skin and Connective Tissue Diseases

Breast Neoplasms

Breast Diseases

Skin Diseases

At the start of the study: blood draw, questionnaire and menstrual calendar ↓ Start planned therapy (or observation/surveillance) for cancer treatment

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Tests in the middle of chemotherapy (if applicable):

Blood draw and collection of monthly menstrual calendars ↓

Tests when chemotherapy is over (if applicable):

Blood draw and collection of monthly menstrual calendars

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Tests every 4 months for about 1 year:

Blood draw, collection of monthly menstrual calendars, and questionnaire ↓

Tests every 6 months for about 1 year:

Blood draw, collection of monthly menstrual calendars, and questionnaire

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Yearly follow-up for about 2 years:

Blood draw collection of monthly menstrual calendars, and questionnaire

Blood draw and questionnaires

Study Schema for Unaffected High Risk Women with BRCA mutations Identify eligible premenopausal patients and obtain informed consent

↓ Register patients at Memorial Sloan-Kettering Cancer Center

↓ Baseline evaluation: Blood draw and baseline reproductive health and sexual questionnaires (Appendix A)/menstrual calendar (Appendix C)

↓ Annual follow-up x 4 years Blood draw and collection of monthly menstrual calendars/follow-up reproductive health and sexual health questionnaires

↓ Year 1 follow up Blood draw and collection of monthly menstrual calendars /follow-up reproductive and sexual health questionnaires

↓ Optional annual follow-up years 2-5 Blood draw and collection of monthly menstrual calendars /follow-up reproductive and sexual health questionnaires

Shari Goldfarb, MD

Kimberly Van Zee, MD

The purpose of this study is to see how the cancer treatment affects the ovaries. Cancer treatment can make it hard for a person to conceive a child in the future. It may also bring on early menopause. We will check blood levels of hormones that the ovaries produce. We will do this before, during, and after the cancer treatment. We will also ask the patient to fill out questionnaires about their menstrual cycle (periods) and information about your health and pregnancies. This may help us learn which women will be more likely to have early menopause.

Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations

Multi-Center Study of Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer BRCA Mutations

in premenopausal breast cancer patients \& to characterize the changes in serum AMH from baseline to 1 year in unaffected high risk BRCA mutation carriers.

Yale University

New York Presbyterian Hospital

Weill Medical College of Cornell University

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
DNA Repair and Genetic Susceptibility to Lung Cancer	NCT00611598	Lung Cancer Single Primary ... Second Primary ...	Blood draw and ... Blood draw and ...	-	Memorial Sloan Kettering Cancer Center
Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations	NCT00823654	Breast Cancer	Blood draw and ... Blood draw and ...	18 Years - 44 Years	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for blood draw and questionnaires