Neoplasms

Digestive System Diseases

All Conditions

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Central Nervous System Depressants

All Drugs and Chemicals

Anti-Arrhythmia Agents

Channel Blockers

Pharmaceutical Solutions

Platelet Aggregation Inhibitors

Anesthetics

Lidocaine

Propofol

Sevoflurane

Anesthetics, Intravenous

Anesthetics, Local

Sodium Channel Blockers

Diuretics, Potassium Sparing

Hypnotics and Sedatives

Anesthetics, General

Anesthetics, Inhalation

Patients will receive a general volatile anesthesia with Sevoflurane as anesthetic agent

Patients will receive a general anesthesia with Propofol as anesthetic agent

Patients will receive a general anesthesia with Propofol as anesthetic agent and will also receive a fully lidocaine infusion according to the lidocaine protocol

10 presumed healthy volunteers that have donated 10 ml of venous blood for serum comparison

Lidocaine 1% Injectable Solution Intervention Protocol for the TIVA and Lidocaine Arm

* Induction: 1.5 mg / kg i.v. bolus before induction (at the vein catch).
* Maintaining anesthesia: continuous infusion with Lidocaine 2 mg / kg / h, up to a maximum of 200 mg / h during maintenance (after IOT until waking)
* Infusion with 1% Lidocaine will be reduced to 1.0- 1.5 mg / kg / hour, max 100 mg / hour, for the first 48 hours postop

Lidocaine 1% Injectable Solution

The patients will donate after consent 10 ml of blood prior and after surgery for further study

Blood extraction

Alexandru Alexa, MD

Ionescu Daniela, MD PHD

Alexandru Alexa

Ionescu Daniela, MD PHD DEEA

Digestive cancers (liver, colonic, pancreatic) have a high incidence and high mortality, their population prevalence is also increasing. Given that the anesthesia techniques and the agents used act directly and indirectly on the immune system during the perioperative period, influencing both the treatment and the prognosis of patients with colorectal cancer who undergo elective interventions, a series of perianesthetic interventions have been proposed in order to reduce morbidity-mortality perioperative.

Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery

Contributions to the Elucidation of the Mechanisms and Effects by Which Certain Perianesthetic Interventions Modify Long-term Evolution of Patients With Digestive Cancers Subjected to Surgery

The investigators aim to correlate the anticancer effects of two anesthetic techniques with tumor markers (p53;p38) and cell proteins involved in proliferation or apoptosis (IGFR;Bcl-2;Bcl-6).

The investigators will report if the anesthetic agent used in cancer surgery influences the serologic values of these markers.

The investigators will investigate the serum of the patients who received different types of anesthesia (elective colorectal cancer surgery) by incubating it with colon cell lines (HCT116). The investigators will concentrate on cell proliferation assay.

The investigators aim to discover how the growth of HCT116 will be influenced by patients' serum in terms of rate of proliferation. The measurements which will be used are Inhibitory Concentration (IC50) measured at 0 , 24 and 48 hours after incubation.

The concentrations will be measured in mcg/ml.

The investigators aim to determine de plasmatic concentration of lidocaine in the patients serum , which have received lidocaine perioperatively.

The investigators will do a Mass-Spec analysis of lidocaine

The investigators will do a follow up for the patients in all the 3 groups. The investigators want to investigate the survival ratio for the patients that had a elective colorectal cancer surgery.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery	NCT04162535	Colorectal Canc...	Lidocaine 1% In... Blood extractio... Sevoflurane Propofol	18 Years - 80 Years	Iuliu Hatieganu University of Medicine and Pharmacy
Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery	NCT04162535	Colorectal Canc...	Lidocaine 1% In... Blood extractio... Sevoflurane Propofol	18 Years - 80 Years	Iuliu Hatieganu University of Medicine and Pharmacy

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