Neoplasms

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Gland and Hormone Related Diseases

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Carcinoma

Adrenocortical Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenocarcinoma

Adrenal Cortex Neoplasms

Adrenal Gland Neoplasms

Endocrine Gland Neoplasms

Adrenal Cortex Diseases

Adrenal Gland Diseases

Endocrine System Diseases

Vasoconstrictor Agents

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Epinephrine

Racepinephrine

Epinephryl borate

Five patients with strong clinical suspicion of adrenocortical carcinoma

Twenty patients without suspicion of adrenal malignancy. These patients should undergo an adrenal vein sampling as part of their routine diagnostics.

Blood samples from both study groups, taken during an adrenal vein sampling, will be compared across the groups.

Blood sampling.

Richard Feelders, Dr.

Richard Feelders

The goal of this observational pilot study is to explore whether we can identify biomarkers predictive for the diagnosis of adrenocortical carcinoma in blood. Five participants who are suspected to have adrenocortical carcinoma will undergo an adrenal vein sampling in order to obtain a blood sample from the adrenal vein. This blood sample will be analyzed and compared to blood samples taken from the adrenal vein of 20 control patients, which are patients who do not have adrenocortical carcinoma. The blood samples of the control patients will be drawn during routine medical care.

Adrenal Vein Sampling as a Tool to Identify Biomarkers That Aid the Diagnosis of Adrenocortical Carcinoma

miRNAs with a log2Fold change \> \|1\| difference in expression in patient compared to control samples.

Presence of mutations will be assessed in patient samples and compared to control samples

Differentially methylated probes and differentially methylated regions will be assessed as those with a beta \>0.8 and \<0.2

Laboratory values will be compared using Mann-Whitney-U tests

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Adrenal Vein Sampling as a Tool to Identify Biomarkers That Aid the Diagnosis of Adrenocortical Carcinoma	NCT05660889	Adrenocortical ...	Blood sampling.	18 Years -	Erasmus Medical Center
Adrenal Vein Sampling as a Tool to Identify Biomarkers That Aid the Diagnosis of Adrenocortical Carcinoma	NCT05660889	Adrenocortical ...	Blood sampling.	18 Years -	Erasmus Medical Center

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