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Ossification, Heterotopic

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Pancrelipase

Pancreatin

Radical operations were performed through central abdominal incisions. The postoperative pathology was pancreatic ductal adenocarcinoma.

The abdominal midline incision was performed and the postoperative pathology was benign.

Hematologic indicators reflecting ossification.

Bone alkaline phosphatase

Abdominal CT scan

Jishu Wei, MD,PhD

Yi Miao, Prof.

Junli Wu, MD,PHD

Jishu Wei, MD,PHD

To investigate whether pancreatic cancer is the cause of heterotopic ossification of abdominal incision.

Heterotopic ossification of abdominal incision (HOAI) has long been regarded as a rare complication after general surgery. However,according to our retrospective analysis. HOAI was more frequently observed in the malignancy group (33/121 cases, 27.3%) than in the non- malignancy group. Because of the many biases in the retrospective analysis, the result was not widely shared.

The purpose of this prospective study is to confirm that pancreatic cancer is the cause of heterotopic ossification of abdominal incisions. According to postoperative pathology, the patients were divided into two groups: pancreatic cancer group and benign diseases group.The researchers will observe whether patients develop heterotopic ossification of the abdominal incision one year after surgery to conclude.

The ossification patients were sequenced with informed consent . Promise to keep their personal information confidential.

Heterotopic Ossification in Abdominal Incision and Pancreatic Cancer

The Causes of Heterotopic Ossification in Abdominal Incision After Pancreatic Surgery：A Single-center Prospective Study

Patients with pancreatic cancer were divided into HOAI and non-HOAI groups to determine whether there were differences between the OS of two groups.

HOAI is determined by CT, whose CT number is similar to that of the same spine.

Preoperative tests were performed and every three months postoperatively

Patients with pancreatic cancer were divided into HOAI and non-HOAI groups to determine whether there were differences in the incidence of distant metastasis and local recurrence between the two groups.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Heterotopic Ossification in Abdominal Incision and Pancreatic Cancer	NCT04049461	Cancer of Pancr... Ossification, H...	Bone alkaline p... Abdominal CT sc...	18 Years - 80 Years	Nanjing Medical University
Heterotopic Ossification in Abdominal Incision and Pancreatic Cancer	NCT04049461	Cancer of Pancr... Ossification, H...	Bone alkaline p... Abdominal CT sc...	18 Years - 80 Years	Nanjing Medical University

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