Neoplasms

All Conditions

Symptoms and General Pathology

Adenoma

Polyps

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

4L-group received 4 bags of PEG and were instructed to drink 2L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate.

3L-group received 3 bags of PEG and were instructed to drink 1L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate.

4L group received double-dose PEG at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes.

4L Polyethylene Glycol

3L group were instructed to drink 1L PEG at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes

3L Polyethylene Glycol

Zhaosheng Li, MD

Yu Bai, MD

Peng Cheng

High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of the dose of Polyethylene Glycol(PEG) on the quality of bowel preparation. This prospective, endoscopist-blinded, randomized, controlled study was conducted. 3L-group received 3 bags of PEG and were instructed to drink 1L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate. 4L-group received 4bags of PEG and were instructed to drink 2 L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate. The primary outcome was the quality of the bowel preparation according to the Boston Bowel Preparation Scale (BBPS). The secondary outcomes included polyp detection rate (PDR), adenoma detection rate (ADR), tolerance, and subjective feelings of patients.

Comparison Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation

Comparison of the Efficacy and Tolerability Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation

The primary end point of the study was adequate bowel preparation quality de ned as a BBPS total score of ≥6 with all segment scores ≥2

The secondary end point of the study included polyp detection rate

The secondary end point of the study included adenoma detection rate

It was a new metric called ADR-Plus, the mean number of incremental adenomas after the fist.

Changhai Hospital

Director of Gastroenterology Dept and Digestive Endoscopy Center

Patients randomized to the intervention arm will be contacted 48-72h before their procedure via telephone using a standardized script and will be provided a link to a website allowing posting of videos for public viewing

The control arm will receive written instruction on preparing for a colonoscopy per standard of care

Video

Standard preparation instructions

Zhaoshen Li, Prof

Yu Bai, M.D.

Zhaoshen Yu, Prof

High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of reinforced education by Video on the quality of bowel preparation. This prospective, endoscopist-blinded, randomized, controlled study was conducted. Reinforced education groups received additional education via reminders by video 2 days before colonoscopy. The primary outcome was the quality of the bowel preparation according to the Boston Bowel Preparation Scale (BBPS). The secondary outcomes included polyp detection rate (PDR), adenoma detection rate (ADR), tolerance, and subjective feelings of patients.

Impact of Reinforced Education by Video on the Quality of Bowel Preparation

The primary end point of the study was adequate bowel prepara- tion quality de ned as a BBPS total score of ≥6 with all segment scores ≥2

Secondary end points included polyp detection rate which would be higher in the colonoscopy with satisfactory bowel preparation.

Secondary end points included adenoma detection rate which would be higher in the colonoscopy with satisfactory bowel preparation.

Director, Head of Department of Gastroenterology, Principal Investigator, Clinical Professor

Digestive System Diseases

Colonic Neoplasms

Colonic Polyps

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Patients receive the standard-of-care bowel preparation instruction.

Patients receive enhanced instructions (SMS, phone call, info website) in addition to the standard-of-care bowel preparation instruction.

Automated delivery of SMS, pre-recorded phone call, and link to an information website.

Enhanced bowel preparation instruction

Minh Pham

Kate FitzGerald

Minh Pham, MBBS

Efficacy Evaluation of Enhanced Bowel Preparation Instructions in Elective Colonoscopy.

This is a prospective, randomized, controlled clinical investigation designed to evaluate the efficacy of enhanced bowel preparation instructions (automated SMS, information website, and pre-recorded phone call) in improving bowel preparation quality in elective colonoscopy.

Subjects from the interventional and control group will receive standard of care bowel preparation instruction.

The interventional group will receive enhanced instructions delivered by automated SMS, information website and pre-recorded phone calls in the 48 hours leading up to the colonoscopy day. The intention is to provide a reminder, to reiterate instruction on clear fluid diet and timing of bowel preparation medication, and to provide additional graphical illustration on the information website.

Subjects in the interventional group must reply "OK" to each automated SMS or press "1" on the keypad at the end of the automated phone call to acknowledge understanding and receipt of instruction. Failure to acknowledge trigger an alert for a booking office staff member to directly call the patient and confirm compliance.

The clinical investigation will be conducted at one hospital in the state of New South Wales, Australia.

Subjects will be randomized to the interventional group (enhanced instruction) versus the control group (standard instruction).

The proceduralist assessing outcome measures at the time of colonoscopy is blinded to the intervention.

The patient cannot be blinded to the allocation. The colonoscopist (care provider) is blinded to the allocation. The investigator and statistician will remain blinded to the allocation until analysis has been conducted.

Effect of Enhanced Interactive Text Messages and Phone Instruction on the Quality of Bowel Preparation for Colonoscopy.

Effect of Enhanced Interactive Text Messages and Phone Instruction on the Quality of Bowel Preparation for Colonoscopy: a Randomised Controlled Trial.

Bowel preparation quality is assessed using the Boston Bowel Preparation Scale (range 0 to 9, with higher scores indicating better bowel preparation quality)

The number of colonoscopy being cancelled within 48 hours of the colonoscopy date. The rates will be compared between the study groups.

The proportion of colonoscopies in which the colonoscope reaches the furthest extent of the colon. The rates will be compared between the study groups.

The proportion of colonoscopies in which a polyp was detected. The rates will be compared between the study groups.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Comparison Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation	NCT03356015	Bowel Preparati... Adenoma Detecti...	4L Polyethylene... 3L Polyethylene...	18 Years - 75 Years	Changhai Hospital
Impact of Reinforced Education by Video on the Quality of Bowel Preparation	NCT03185299	Bowel Preparati... Adenoma Detecti...	Video Standard prepar...	18 Years - 80 Years	Changhai Hospital
Effect of Enhanced Interactive Text Messages and Phone Instruction on the Quality of Bowel Preparation for Colonoscopy.	NCT04898426	Colon Polyp Colon Neoplasm	Enhanced bowel ...	18 Years -	Griffith Base Hospital
Impact of Reinforced Education by Video on the Quality of Bowel Preparation	NCT03185299	Bowel Preparati... Adenoma Detecti...	Video Standard prepar...	18 Years - 80 Years	Changhai Hospital

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