Neoplasms

All Conditions

Symptoms and General Pathology

Adenoma

Polyps

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

4L-group received 4 bags of PEG and were instructed to drink 2L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate.

3L-group received 3 bags of PEG and were instructed to drink 1L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate.

4L group received double-dose PEG at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes.

4L Polyethylene Glycol

3L group were instructed to drink 1L PEG at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes

3L Polyethylene Glycol

Zhaosheng Li, MD

Yu Bai, MD

Peng Cheng

High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of the dose of Polyethylene Glycol(PEG) on the quality of bowel preparation. This prospective, endoscopist-blinded, randomized, controlled study was conducted. 3L-group received 3 bags of PEG and were instructed to drink 1L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate. 4L-group received 4bags of PEG and were instructed to drink 2 L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate. The primary outcome was the quality of the bowel preparation according to the Boston Bowel Preparation Scale (BBPS). The secondary outcomes included polyp detection rate (PDR), adenoma detection rate (ADR), tolerance, and subjective feelings of patients.

Comparison Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation

Comparison of the Efficacy and Tolerability Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation

The primary end point of the study was adequate bowel preparation quality de ned as a BBPS total score of ≥6 with all segment scores ≥2

The secondary end point of the study included polyp detection rate

The secondary end point of the study included adenoma detection rate

It was a new metric called ADR-Plus, the mean number of incremental adenomas after the fist.

Changhai Hospital

Director of Gastroenterology Dept and Digestive Endoscopy Center

gum+PEG

polyethylene glycol

In this randomized controlled study, consecutive outpatients scheduled for elective colonoscopy were randomized into two groups. Group A patients (n = 150) used 2 L PEG before colonoscopy. Patients in group B (n = 150) were additionally advised to chew sugarless gum plus 2 L PEG, The overall quality of colonoscopy cleaning was evaluated using the Boston Bowel Preparation Scale by endoscopists who was blinded to the intervention. Difficulty of procedure, patients' tolerance, and adverse events were also evaluated.

Effect of Gum Chewing on Bowel Cleansing Before Colonoscopy

Effect of Gum Chewing on Bowel Cleansing Before Colonoscopy: A Prospective Randomized Study

Director of Gastroenterology Dept.

Dermatologic Agents

All Drugs and Chemicals

Simethicone

Emollients

2L PEG

2L PEG+simethicone

LI ZHAO SHEN, M.D

To evaluate the efficacy, visibility of low volume polyethyleneglycol-simeticone (2-LPEG-S) for colonoscopy.

In this randomized controlled study, consecutive outpatients scheduled for elective colonoscopy were randomized into two groups. Group A patients (n = 300) used only 2 L PEG before colonoscopy. Patients in group B (n = 300) were additionally advised to simeticone plus 2 L PEG, The overall quality of colonoscopy cleaning was evaluated using the Boston Bowel Preparation Scale by a single endoscopist who was blinded to the intervention. Visibility was blindly assessed for the amount of air bubbles and adenoma detection rate (ADR). Difficulty of procedure, and adverse events were also evaluated.

Premedication Simethione Improves Visibility During Bowel Cleansing for Colonoscopy

Five areas of the colon (rectosigmoid, descending, transverse, ascending, and cecum) were graded for the amount of air bubbles.The amount of intraluminal air bubbles was classified into four grades as shown below: Grade 0 = No or minimal scattered bubbles; Grade 1 = Bubbles covering at least half the luminal diameter; Grade 2 = Bubbles covering the circumference of the lumen; Grade 3 = Bubbles filling the entire lumen.

First Affiliated Hospital of Zhejiang University

Sir Run Run Shaw Hospital

Tongji Hospital

Qilu Hospital of Shandong University

Zhongda Hospital

Jinan Military General Hospital

First Hospital of China Medical University

Digestive Endoscopy Center

Patients randomized to the intervention arm will be contacted 48-72h before their procedure via telephone using a standardized script and will be provided a link to a website allowing posting of videos for public viewing

The control arm will receive written instruction on preparing for a colonoscopy per standard of care

Video

Standard preparation instructions

Zhaoshen Li, Prof

Yu Bai, M.D.

Zhaoshen Yu, Prof

High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of reinforced education by Video on the quality of bowel preparation. This prospective, endoscopist-blinded, randomized, controlled study was conducted. Reinforced education groups received additional education via reminders by video 2 days before colonoscopy. The primary outcome was the quality of the bowel preparation according to the Boston Bowel Preparation Scale (BBPS). The secondary outcomes included polyp detection rate (PDR), adenoma detection rate (ADR), tolerance, and subjective feelings of patients.

Impact of Reinforced Education by Video on the Quality of Bowel Preparation

The primary end point of the study was adequate bowel prepara- tion quality de ned as a BBPS total score of ≥6 with all segment scores ≥2

Secondary end points included polyp detection rate which would be higher in the colonoscopy with satisfactory bowel preparation.

Secondary end points included adenoma detection rate which would be higher in the colonoscopy with satisfactory bowel preparation.

Director, Head of Department of Gastroenterology, Principal Investigator, Clinical Professor

Central Nervous System Depressants

Dyclonine

Anesthetics

Anesthetics, Local

used 3L PEG+Dyclonine Hydrochloride Mucilage

Group A patients (n = 300) used only 3L PEG before colonoscopy.

3L PEG

Patients in group B (n = 300) were additionally advised to Dyclonine Hydrochloride Mucilage plus 3 L PEG

3L PEG+Dyclonine Hydrochloride Mucilage

Yu Bai

In this randomized controlled study, consecutive outpatients scheduled for elective colonoscopy were randomized into two groups. Group A patients (n = 300) used only 3L PEG before colonoscopy. Patients in group B (n = 300) were additionally advised to Dyclonine Hydrochloride Mucilage plus 3L PEG, The overall quality of colonoscopy cleaning was evaluated using the Boston Bowel Preparation Scale by a single endoscopist who was blinded to the intervention. Visibility was blindly assessed for the amount of air bubbles and adenoma detection rate (ADR). Difficulty of procedure, and adverse events were also evaluated.

Premedication Dyclonine Improves Visibility During Bowel Cleansing for Colonoscopy

The amount of intraluminal air bubbles was classified into four grades as shown below: Grade 0 = No or minimal scattered bubbles; Grade 1 = Bubbles covering at least half the luminal diameter; Grade 2 = Bubbles covering the circumference of the lumen; Grade 3 = Bubbles filling the entire lumen. Bubbles filling the entire lumen.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Comparison Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation	NCT03356015	Bowel Preparati... Adenoma Detecti...	4L Polyethylene... 3L Polyethylene...	18 Years - 75 Years	Changhai Hospital
Effect of Gum Chewing on Bowel Cleansing Before Colonoscopy	NCT02507037	Bowel Preparati... Adenoma Detecti...	gum+PEG polyethylene gl...	18 Years - 65 Years	Changhai Hospital
Premedication Simethione Improves Visibility During Bowel Cleansing for Colonoscopy	NCT02540239	Bowel Preparati... the Amount of A... Adenoma Detecti...	2L PEG 2L PEG+simethic...	18 Years - 65 Years	Changhai Hospital
Premedication Simethione Improves Visibility During Bowel Cleansing for Colonoscopy	NCT02540239	Bowel Preparati... the Amount of A... Adenoma Detecti...	2L PEG 2L PEG+simethic...	18 Years - 65 Years	Changhai Hospital
Impact of Reinforced Education by Video on the Quality of Bowel Preparation	NCT03185299	Bowel Preparati... Adenoma Detecti...	Video Standard prepar...	18 Years - 80 Years	Changhai Hospital
Impact of Reinforced Education by Video on the Quality of Bowel Preparation	NCT03185299	Bowel Preparati... Adenoma Detecti...	Video Standard prepar...	18 Years - 80 Years	Changhai Hospital
Effect of Gum Chewing on Bowel Cleansing Before Colonoscopy	NCT02507037	Bowel Preparati... Adenoma Detecti...	gum+PEG polyethylene gl...	18 Years - 65 Years	Changhai Hospital
Premedication Dyclonine Improves Visibility During Bowel Cleansing for Colonoscopy	NCT03352700	Bowel Preparati... the Amount of A... Adenoma Detecti...	3L PEG 3L PEG+Dyclonin...	18 Years - 75 Years	Changhai Hospital

Spots Global Cancer Trial Database for bowel preparation scale