Neoplasms

Symptoms and General Pathology

All Conditions

Nervous System Diseases

Neoplasm Metastasis

Dystonia

Dystonic Disorders

Neoplastic Processes

Dyskinesias

Neurologic Manifestations

Movement Disorders

Central Nervous System Diseases

Muscle Relaxants, Central

All Drugs and Chemicals

Baclofen

GABA Agonists

Neurotransmitter Agents

Stereotactic lesioning of the thalamus or gloves pallidus

Combined anterior and posterior lumbosacral rhizotomy

Bilateral globus pallidus internus deep brain stimulation

Stereotactic radiofrequency lesioning of the pallidum or thalamus

Brain Lesioning

Deep brain stimulation

Intra-thecal baclofen infusion

Walid A Abdel Ghany, MD

The disability inflected by dystonia encouraged the development of many neurosurgical procedures.

This is a prospective study included 120 patients suffering from intractable secondary dystonia.

They were subjected to different neurosurgical treatments and were assessed through the follow up period

Background:

Secondary dystonia are the syndromes that have dystonic symptoms due to brain insult which can be associated with neonatal encephalopathy syndromes, trauma, vascular injury, infections, demyelinations, or hereditary disorders associated with neurodegenerative process. The disability inflected by dystonia encouraged the development of many neurosurgical procedures in order to improve the quality of life of these patients.

The aim of this study was to compare the outcomes of different Neuroablative and modulation techniques in treatment of secondary dystonia.

Patients and methods This is a prospective study included 120 patients suffering from intractable secondary dystonia. Ablative techniques included the brain lesioning procedure and combined anterior and posterior lumbar rhizotomy (CAPR). Modulation techniques included deep brain stimulation (DBS) and intrathecal baclofen therapy (ITB). Patients with focal dystonia were included in the Botulinum toxin injection group. Patients with generalized dystonia were included in either of the brain lesioning or the deep brain stimulation, and patients with predominant affection of both lower limbs were included in either of the (CAPR) or the (ITB) groups.

Assessment measures included the evaluation of the muscle tone, range of motion, and the Burke-Fahn-Marsden dystonia rating scale through a follow up period of one year.

Neuroablation Versus Neuromodulation Techniques for Treatment of Secondary Dystonia

Comparative Study Between the Functional Outcomes of Neuromodulation and Neuroablation Techniques for Treatment of Secondary Dystonia

Dystonia rating scale Higher scores means a worse condition of the disease, while low scores indicate a less involvement of the body

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Neuroablation Versus Neuromodulation Techniques for Treatment of Secondary Dystonia	NCT03347240	Secondary Dysto...	Brain Lesioning Combined anteri... Deep brain stim... Intra-thecal ba...	3 Years - 50 Years	Ain Shams University
Neuroablation Versus Neuromodulation Techniques for Treatment of Secondary Dystonia	NCT03347240	Secondary Dysto...	Brain Lesioning Combined anteri... Deep brain stim... Intra-thecal ba...	3 Years - 50 Years	Ain Shams University

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