Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Diseases and Abnormalities at or Before Birth

Heart and Blood Diseases

Breast Neoplasms

Congenital Abnormalities

Vascular Malformations

An ultrasound contrast agent, Definity, will be administered started through the IV line already in use. The imaging will be performed to map vascular flow.

The breast will be scanned by a double ultrasound transducer system in a holder over the area of the breast to be biopsied. The machine will be set with different settings and the scan repeated, possibly multiple times.

Ultrasound Imaging with Contrast

Jerry L. LeCarpentier, Ph.D.

The purpose of this study is to determine if breast imaging with ultrasound can be improved by using 1) a ultrasound attachment with two transducers and 2) a contrast agent. These changes might allow smaller blood vessels to be seen than under the way breast ultrasound is usually performed.

The purpose of this study is to determine if performing ultrasound with an attachment made up of two transducers (rather than just a single transducer) will provide more information about the blood vessels in the breast than the current attachment.

The study will also examine the question of whether use of an ultrasound contrast agent will the scanner to see smaller blood vessels than are detected without the agent.

Evaluate Breast Masses Using a New Method of Ultrasound Contrast to Detect Abnormal Blood Flow in Breasts

Characterization of Breast Masses Using a New Method of Ultrasound Contrast Agent Imaging in 3D Mapping of Vascular Anomalies

University of Michigan

Principal Investigator

Breast Diseases

Skin Diseases

All Drugs and Chemicals

Fluorides

Fluorodeoxyglucose F18

David Feiglin, MD

This is a study looking at advanced imaging such as PET/CT and MRI to see if they can provide a more accurate assessment of the patient with dense breasts or difficult to interpret mammograms. In addition, the ability to determine whether one or the other is more accurate or whether both together would be appropriate in this clinical situation, may be able to be measured.

The MRI studies are very sensitive for detection of breast histopathology but less specific in differentiating between small low grade malignancies are more benign pathologies. Multifocal pathology can be challenging in determining site(s) for biopsy.

PET scanning is specific in the measurement of metabolic glucose activity of various histopathologies and is accurate in differentiating aggressive from benign pathology in multifocal breast disease. A further drawback of PET is the lack of ability to observe lesions less than 3-4mm in diameter.

In select cases the combination of MR and PET/CT is able to come to a more conclusive diagnosis - specifically with bilateral or multifocal breast disease.

Study Comparing the PET Scan and MRI in Identifying Breast Malignancies in Women With Breast Abnormalities

Comparative Study of the Diagnostic Accuracy of Scintimammography (Fluorine 18-FDG PET Scintigraphic Imaging) and Magnetic Resonance Imaging in Identifying Malignant Breast Lesions, In Subjects With Breast Abnormalities

State University of New York - Upstate Medical University

Chairman Radiology Department

Subjects will undergo a 3D breast Tomosynthesis imaging scan. This is a one time breast imaging scan will last approximately 15 minutes.

Breast Tomosynthesis

Alexis V. Nees, M.D.

The purpose of this study is to compare 3D mammography with digital mammography in women with dense breasts for the detection and evaluation of masses and/or breast cancer.

Detection and/or Evaluation of Dense Breast Abnormalities Using Tomosynthesis and Digital Mammography

Assessment of Emerging Technology: Comparison of Breast Tomosynthesis and Digital Mammography in the Evaluation of Heterogeneously Dense and Extremely Dense Breasts

Interest of sensitivity, specificity and area under region of concern curve for malignant mass detection. During review, the number of masses and location and size of each mass will be recorded. An additional estimate of probability of malignancy will be recorded for each image sets.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluate Breast Masses Using a New Method of Ultrasound Contrast to Detect Abnormal Blood Flow in Breasts	NCT00722683	Breast Cancer Breast Abnormal...	Ultrasound Imag...	18 Years -	University of Michigan
Study Comparing the PET Scan and MRI in Identifying Breast Malignancies in Women With Breast Abnormalities	NCT00639535	Breast Disease		18 Years -	State University of New York - Upstate Medical University
Study Comparing the PET Scan and MRI in Identifying Breast Malignancies in Women With Breast Abnormalities	NCT00639535	Breast Disease		18 Years -	State University of New York - Upstate Medical University
Detection and/or Evaluation of Dense Breast Abnormalities Using Tomosynthesis and Digital Mammography	NCT00722059	Breast Neoplasm... Breast Abnormal...	Breast Tomosynt...	30 Years -	University of Michigan

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