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Physical Therapy consult for post op care and general physical activity recommendation 1-4 weeks prior to starting chemotherapy.

Phone calls designed to support the patient to maintain current activity level.

Physical Therapy consult for post-op care 1-4 weeks prior to starting chemotherapy.

Exercise prescription aimed at increasing physical activity by a minimum of 10 MET hours/week.

Motivational phone calls aimed at encouraging the patient to adhere to their exercise prescription.

A physical therapist will design an exercise plan for each participant on the intervention arm. The participants randomized to the intervention arm will also receive phone calls to assist with tracking the study participant's exercise and motivating the study participant to adhere to the exercise prescription.

Exercise prescription

Mary Chamberlin, MD

This study is designed to randomly assign breast cancer patients requiring and agreeing to chemotherapy into two groups. One group will be receive an exercise prescription aimed at increasing physical activity by a minimum of 10 MET (metabolic equivalent task) hours per week. The other group will not receive a exercise prescription but their activity will be recorded. The hypothesis is that participants that are most active will exhibit improved chemotherapy completion rates, improved fitness, less fatigue and lower levels of markers for inflammation in their blood.

This is a prospective, randomized, single institution feasibility trial. The efficacy of an exercise intervention during chemotherapy for sedentary breast cancer patients will be tested. The investigators goal is to recruit 120 women and men. Assuming 20% attrition rate, 96 will be randomized to two arms, comparing patients assigned to a physical activity program plus general health education materials versus patients assigned to receive standard general health education materials only. Study measures will be obtained before intervention, at 24 weeks, and at the end of the intervention, approximately week 32.

A Randomized, Controlled Trial to Determine the Effects of an Exercise Intervention on Physical Activity During Chemotherapy for Patients With Early Stage Breast Cancer

A log will be used to record patient's exercise activity and pedometer data on a weekly and monthly basis.

The RDI is calculated by (delivered dose)/(standard dose) x 100. Delivered dose = (actual total dose in mg/m2)/ (total days required to complete the treatment) Standard dose = (recommended total dose) / (total days planned to complete the treatment)

Fatigue as measured by the FACIT-F survey

Fasting insulin levels measured in blood at baseline (day -28 to day 1) and week 32

How the participant is feeling about the exercise.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Randomized, Controlled Trial to Determine the Effects of an Exercise Intervention on Physical Activity During Chemotherapy for Patients With Early Stage Breast Cancer	NCT02159157	Early Stage Bre...	Exercise prescr...	18 Years - 99 Years	Dartmouth-Hitchcock Medical Center
A Randomized, Controlled Trial to Determine the Effects of an Exercise Intervention on Physical Activity During Chemotherapy for Patients With Early Stage Breast Cancer	NCT02159157	Early Stage Bre...	Exercise prescr...	18 Years - 99 Years	Dartmouth-Hitchcock Medical Center

Spots Global Cancer Trial Database for breast cancer, exercise