Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Skin and Connective Tissue Diseases

Gland and Hormone Related Diseases

Rare Diseases

Uterine Cervical Neoplasms

Endometrial Neoplasms

Breast Neoplasms

Ovarian Neoplasms

Breast Diseases

Skin Diseases

Endocrine Gland Neoplasms

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Genital Neoplasms, Female

Urogenital Neoplasms

Endocrine System Diseases

Gonadal Disorders

Uterine Neoplasms

Uterine Cervical Diseases

Uterine Diseases

Ovarian Cancer

Anti-Infective Agents

All Drugs and Chemicals

Antineoplastic Agents

Vitamins

Acetic Acid

Retinol acetate

Screening of asymptomatic women for Breast and Cervical cancer in the age group of 35-64 years. Diagnostic assessment of symptomatic women for Ovarian and Endometrial cancer in the age group of 50-64 years.

Clinical Breast Examination and Sonography followed by Fine needle aspiration biopsy (FNAB) of screen positive cases.

Breast Cancer Screening and Diagnosis

Visual Inspection with Acetic acid, PAP smear or Human Papilloma Virus DNA testing followed by Cryotherapy of screen positive cases.

Cervical Cancer Screening and Diagnosis

Transvaginal sonogram and clinical evaluation in post menopausal women with symptoms suggestive of ovarian cancer.

Ovarian Cancer Screening and Diagnosis

Transvaginal sonographic assessment of the endometrial stripe in post menopausal women with abnormal bleeding.

Endometrial Cancer Screening and Diagnosis

Edmundo Mauad, MD, PhD

Cornelia Haener, MD

Shelly Malhotra

R.G. Pinto, MD

Sharmila Sardesai, MD

R. G. Pinto, MD

Eugene D'Silva, MD

Weiwei Yang, MD

Diljeet K Singh, MD

Adhemar Longatto Filho, MD

The purpose of this study is to implement a community-based combined program for early detection of breast, cervical, ovarian and endometrial cancer in low-resource countries delivered through a free standing or a mobile Well Woman Clinic. The goals of this program are to downstage cancers and improve mortality rates using low-cost early detection methods. These programs will be implemented in regions where early cancer detection strategies are not in place and cancers present at advanced stages with resultant high mortality. Currently, there are three target project sites: Cambodia (June 2011), India (June 2011), and Brazil (March 2011). Memorandums of Understanding have been secured with local health organizations in each region to establish clinic operations. Each clinic would serve an approximate target population of 100,000 amongst whom about 12,000 eligible women (4-5,000 annually) will be invited to be screened for breast and cervical cancer over a three-year time span.

We will study the use of sonographic screening in addition to Clinical Breast Examination in low resource settings where screening programs are not currently in place and establishing a population based mammographic screening would be expensive, resource intensive, and difficult if not impossible to implement. The effectiveness of the screening and diagnostic methodology used for early detection of breast, cervical, ovarian and endometrial cancers in low resource settings will be studied. The program would involve screening of asymptomatic women for Breast and Cervical cancer and diagnostic assessment of symptomatic women for Ovarian and Endometrial cancer. Women in the age group of 30-59 yrs will be screened once every three years utilizing the following methods: Breast - clinical breast examination \[CBE\] and Sonography, followed by Fine needle aspiration biopsy (FNAB) of screen positive cases; Cervical - Human Papilloma Virus DNA testing followed by Cryotherapy of screen positive cases (Single visit, screen and treat approach); Ovarian - Transvaginal sonogram and clinical evaluation; Endometrial - Transvaginal sonographic assessment of the endometrial stripe.

Early Detection of Cancers in Low Resource Countries

Efficacy of a Combined Program for Early Detection of Breast and Gynecological Cancers in Low Resource Countries

This study will examine the effectiveness of an innovative, low-cost screening and diagnostic methodology used for combined early detection of breast and gynecological cancers in low resource regions where early cancer detection strategies are not in place and cancers currently are diagnosed at advanced stages with resultant high mortality.

This study will examine the effectiveness of Clinical Breast Examination combined with Ultrasonography for breast cancer screening and detection in low resource settings where X-ray mammography proves not feasible in terms of cost, technology, and staff.

Woman's Cancer Foundation

Mahesh Shetty, MD/President

Mythreyi B Chatfield, PhD

The National Mammography Database (NMD) leverages data that radiology practices are already collecting under federal mandate by providing them with comparative information for national and regional benchmarking. Participants receive semi-annual feedback reports that include important benchmark data such as cancer detection rates, positive predictive value rates and recall rates. Participation in the NMD is free to Breast Imaging Center of Excellence (BICOE) facilities.

National Mammography Database

This outcome measure is measured using one year of follow-up after a mammogram is performed on a woman, and is aggregated by interpreting physician. Because the NMD is a registry and screening mammograms are annual exams for most patients, this measure is calculated each year using one year of follow-up.

American College of Radiology

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Early Detection of Cancers in Low Resource Countries	NCT01178736	Breast Neoplasm... Uterine Cervica... Ovarian Neoplas... Endometrial Neo...	Breast Cancer S... Cervical Cancer... Ovarian Cancer ... Endometrial Can...	30 Years - 64 Years	Woman's Cancer Foundation
Early Detection of Cancers in Low Resource Countries	NCT01178736	Breast Neoplasm... Uterine Cervica... Ovarian Neoplas... Endometrial Neo...	Breast Cancer S... Cervical Cancer... Ovarian Cancer ... Endometrial Can...	30 Years - 64 Years	Woman's Cancer Foundation
National Mammography Database	NCT01900821	Breast Cancer S...		2 Years -	American College of Radiology

Spots Global Cancer Trial Database for breast cancer screening and diagnosis