Neoplasms

All Conditions

Skin and Connective Tissue Diseases

Carcinoma

Breast Neoplasms

Carcinoma, Ductal

Carcinoma in Situ

Carcinoma, Intraductal, Noninfiltrating

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenocarcinoma

Breast Carcinoma In Situ

Only one clinician examined the woman's mammograms for signs of cancer and recommended whether to recall her for further tests or not.

Two clinicians examined the woman's mammograms for signs of cancer and recommended whether to recall her for further tests or not.

One clinician examined each woman's mammograms for signs of cancer

Breast Screening Mammography with single reader

Two clinicians seperately examined each woman's mammograms for signs of cancer

Breast screening mammography with two readers

Threshold used by readers examining the breast screening mammograms, defined using their previous proportion of cases recalled

Test threshold

Sian Taylor-Phillips, PhD

Analysis of women's medical records to understand the impact of previous changes to breast cancer screening (increase from one to two clinicians examining each woman's mammograms, and what proportion of women they recall for further tests)

Retrospective observational study examining the records and outcomes of women who attended breast cancer screening between 1988 and 2016. Linkage of records from the breast screening service, the cancer registry, and mortality. Analysis of whether changing the threshold for whether to recall women for further tests or the number of clinicians examining the mammograms for signs of cancer affects outcomes.

Patient Outcomes From Second Film-readers and Test Threshold Relaxation in Breast Screening

Patient Outcomes From Second Film-readers and Test Threshold Relaxation in Breast Screening: An Observational Retrospective Cohort Study

We do not have Office of Data Release permissions to share these data with other researchers

Overdiagnosis of breast cancer (measured as difference in total cancer incidence, screen and symptomatic). Will also report mechanism of action (number of screen detected cancers, number of symptomatically detected cancers at 3,13, and 30 years follow-up)

Biopsy proven cancers detected at screening

Recall of women for further tests after screening which did not result in detection of cancer

Mortality due to breast cancer (dependent on securing follow-on funding)

Mortality due to any cause (dependent on securing follow on funding)

Size, grade and stage (reported overall, screen detected, and symptomatic detected).

Treatment received as a proxy for treatment associated morbidity (reported overall, screen detected and symptomatically detected, if follow on funding obtained)

Survival without a diagnosis of breast cancer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Patient Outcomes From Second Film-readers and Test Threshold Relaxation in Breast Screening	NCT04365114	Breast Cancer Ductal Carcinom...	Breast Screenin... Breast screenin... Test threshold	47 Years - 73 Years	University of Warwick
Patient Outcomes From Second Film-readers and Test Threshold Relaxation in Breast Screening	NCT04365114	Breast Cancer Ductal Carcinom...	Breast Screenin... Breast screenin... Test threshold	47 Years - 73 Years	University of Warwick

Spots Global Cancer Trial Database for breast screening mammography with single reader