Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Symptoms and General Pathology

Substance Related Disorders

Lung Neoplasms

Cough

Carcinoma, Non-Small-Cell Lung

Carcinoma

Drug-Related Side Effects and Adverse Reactions

Respiration Disorders

Respiratory Tract Diseases

Signs and Symptoms, Respiratory

Chemically-Induced Disorders

Carcinoma, Bronchogenic

Bronchial Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Participants will receive Breztri Aerosphere twice a day from 3 days before surgery to 14 days after surgery

Participants will receive 0.9% normal saline twice a day from 3 days before surgery to 14 days after surgery

Breztri Aerosphere is used to control and prevent symptoms (such as wheezing and shortness of breath) caused by ongoing lung disease (chronic obstructive pulmonary disease-COPD, which includes chronic bronchitis and emphysema).

Breztri Aerosphere

Placebo

Cough after lobectomy is common. The prevention and treatment of cough after lobectomy is not standardized. Breztri Aerosphere is often used to relieve cough. Therefore, we conduct a single center placebo-controlled study to evaluate the efficacy and safety of perioperative use of Breztri Aerosphere in relieving cough after lobectomy.

This study is a single-center, prospective, randomized, controlled clinical trial to understand the efficacy and safety of perioperative use of Breztri in relieving cough after lobectomy. This study plans to include 128 subjects from the Department of Thoracic Surgery of the First Affiliated Hospital of Guangzhou Medical University. Participants will be randomly divided into according Breztri group and placebo group to the ratio of 1:1. Participants in Placebo group will receive 0.9% normal saline for 3 days before operation and 14 days after operation (n=64). Participants in Breztri group will receive Breztri for 3 days before operation and 14 days after operation (n=64). All patients will undergo screening and baseline visits. After sugery, they will be followed up for 2 months.

Efficacy and Safety of Perioperative Use of Breztri Aerosphere to Relieve Cough After Lobectomy

Efficacy and Safety of Perioperative Use of Breztri Aerosphere to Relieve Cough After Lobectomy: A Prospective, Randomized, Placebo-controlled Single Center Trial

Cough Evaluation Test (CET) is an easy way to assess the cough condition. A Visual Analogue Scale (VAS) is a cough rating scale. Significnant cough means VAS more than 3 or any item of CET score more than 2.

Cough Evaluation Test (CET) is an easy way to assess the cough condition

Leicester Cough Questionnaire in Mandarin-Chinese (LCQ-MC) is a useful questionnaire to evaluate cough after surgery

we test the inflammatory factor 3 days before surgery and 1 day after surgery

we make a chest radiograph after surgery to find the postoperative pneumonia

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Efficacy and Safety of Perioperative Use of Breztri Aerosphere to Relieve Cough After Lobectomy	NCT05472350	Lung Cancer, No... Perioperative Cough Drug Effect Drug Toxicity	Breztri Aerosph... Placebo	18 Years - 75 Years	The First Affiliated Hospital of Guangzhou Medical University
Efficacy and Safety of Perioperative Use of Breztri Aerosphere to Relieve Cough After Lobectomy	NCT05472350	Lung Cancer, No... Perioperative Cough Drug Effect Drug Toxicity	Breztri Aerosph... Placebo	18 Years - 75 Years	The First Affiliated Hospital of Guangzhou Medical University

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