Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

In this cohort, women recruited participated to organised breast cancer screening. They must not have an invasive breast cancer.

They will have 3 liquid biopsy : the first at inclusion and then at each mammogram every two years (organised breast cancer screening).

In this cohort, women for who an invasive breast cancer has been diagnose will be included.

Only one liquid biopsy will be collected before any treatment.

In this cohort, women with high risk of BRCA1/2 mutation but without invasive breast cancer.

6 liquid biopsies will be collected : each year after inclusion during 5 years.

Blood sample collection during follow-up of the three cohorts of patients

liquid biopsy

Angeline GINZAC, PhD

Emilie THIVAT, PhD

Jean-Philippe SPANO, Md, PhD

Luis TEIXEIRA, Pr

Joseph GLIGOROV, MD, PhD

Frédérique PENAULT-LLORCA, Pr

Bruno De FRAISSINETTE, MD

Benoit MEUSUROLLE, MD, PhD

The purpose of this study is to validate the interest of broadband spectroscopy analysis (femto/attosecond by infrared laser) on liquid biopsies in breast cancer screening.

Each patient will have one or more liquid biopsy during the follow-up according to the cohort and have a mammogram at the same time.

Biopsies will be analysed by broadband spectroscopy in order to compare the results to mammogram result.

Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening

Multicenter Large-scale Validation Study of the Interest of Broadband Spectroscopy Analysis (Femto/Attosecond by Infrared Laser) on Liquid Biopsies in Breast Cancer Screening

To validate the value of molecular profiling analysis in broadband laser spectroscopy on liquid biopsies for invasive breast cancer screening by comparing a cohort of patients with localized invasive breast cancer (Stage I/II) to a cohort of women without invasive breast cancer from organized or individual age-matched screening.

The results of high-speed laser spectroscopy analysis on liquid biopsies will be correlated with mammography data

Estimate the rate of detection of invasive breast cancer occurring within 5 years of examination in the control group according to the reference method (mammography) and the innovative method ("n-variable molecular profiles") from the baseline analysis performed at Max Planck Institute and algorithmic analysis

To study the confounding role of hormonal status and concomitant inflammatory states in the structure of molecular profiles derived from broadband laser spectroscopy

To study the molecular profiles derived from broadband laser spectroscopy on liquid biopsies in a cohort of high-risk women (BRCA1/2) not carrying invasive breast cancer, and to compare their positioning in relation to the 2 main cohorts of the study (patients carrying invasive breast cancer without mutation and controls without invasive breast cancer).

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening	NCT04273542	Breast Cancer F... BRCA1 Mutation BRCA2 Mutation	liquid biopsy	18 Years -	Centre Jean Perrin
Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening	NCT04273542	Breast Cancer F... BRCA1 Mutation BRCA2 Mutation	liquid biopsy	18 Years -	Centre Jean Perrin

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