Spots Global Cancer Trial Database for liquid biopsy
Every month we try and update this database with for liquid biopsy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Adjuvant TRastuzumab Deruxtecan for HER2-positive Gastroesophageal Cancer With Persistence of miNImal Residual Disease | NCT06253650 | Gastric Cancer HER2-positive G... | Experimental Control | 18 Years - | Gruppo Oncologico del Nord-Ovest | |
| The circTeloDIAG: Liquid Biopsy for Glioma Tumor | NCT04931732 | Glioma | ctDNA analysis | 18 Years - 90 Years | Hospices Civils de Lyon | |
| Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors | NCT05383872 | Glioblastoma Glioma Liquid Biopsy | Focused Ultraso... | 18 Years - 80 Years | InSightec | |
| A Proof of Concept Study of Pan-cancer Early Detection by Liquid Biopsy | NCT04972201 | Cancer | Multi-cancer ea... | 40 Years - 75 Years | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | |
| New Strategies to Detect Cancers in Carriers of Mutations in RB1 | NCT04164134 | Retinoblastoma Secondary Prima... | blood draw | 0 Years - 99 Years | Amsterdam UMC, location VUmc | |
| An Observational Study to Evaluate the Clinical Utility of the Oncomine Precision Assay Within the Exactis Network | NCT04564079 | NSCLC | 18 Years - | Exactis Innovation | ||
| Circulating Tumor DNA Study in Patients With Endometrial Cancer | NCT05955079 | Endometrial Can... | Whole blood | 18 Years - | Assistance Publique - Hôpitaux de Paris | |
| A Prospective Interventional Study on Early Screening for Lung Cancer Using Liquid Biopsy | NCT06422637 | Liquid Biopsy f... | Liquid Biopsy E... | 40 Years - 75 Years | The First Affiliated Hospital of Guangzhou Medical University | |
| BRAINFUL (BRAIN Tumor Focused Ultrasound-enabled Liquid Biopsy) Trial | NCT04940507 | Brain Neoplasms Liquid Biopsy | Magnetic Resona... Magnetic Resona... | 18 Years - | University Health Network, Toronto | |
| Study of Circulating Tumor DNA (ctDNA) Kinetics in Immuno-oncology (IO-KIN) | NCT04606940 | Head and Neck C... Advanced Cancer Metastatic Canc... HNSCC Squamous Cell C... | 18 Years - | University Health Network, Toronto | ||
| AssesSment of Early-deteCtion basEd oN liquiD Biopsy in GASTRIC Cancer, ASCEND-Gastric | NCT05224596 | Cancer | Blood draw and ... | 40 Years - 75 Years | Shanghai Zhongshan Hospital | |
| Early Detection of Five Common Cancers Using the ctDNA Analysing Test | NCT05227261 | Cancer, Lung Cancer, Breast Cancer Liver Cancer, Colorec... Liquid Biopsy Circulating Tum... Cancer, Gastric | 40 Years - | Gene Solutions | ||
| Deferred Cytoreductive Nephrectomy in Synchronous Metastatic Renal Cell Carcinoma: The NORDIC-SUN-Trial | NCT03977571 | Kidney Cancer Renal Cell Carc... Synchronous Neo... | Cytoreductive n... Tissue sampling | 18 Years - | University of Aarhus | |
| Evaluation of Treatment Predictors Reflecting Beta-catenin Activation in Hepatocellular Carcinoma | NCT04965454 | Hepatocellular ... | Fluorine-18 flu... | 18 Years - | Queen's Medical Center | |
| Artificial Intelligence for Help Non-Small Cell Lung Cancer: Measure Cancer Biology and Treatment Response Via Imaging | NCT05254132 | Non Small Cell ... | Liquid biopsy | 18 Years - | OncoRadiomics | |
| Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer | NCT05524012 | Locally Advance... Neoadjuvant Tre... Radiotherapy Adaptive Treatm... | Blood sample MRI scan | 18 Years - | Jena University Hospital | |
| AssesSment of Early-deteCtion basEd oN liquiD Biopsy in Hepatobiliary Cancer Malignancies | NCT04835675 | Hepatobiliary M... | Multi-cancer ea... | 40 Years - 75 Years | Zhujiang Hospital | |
| Implementation of Up-front ctDNA Into Lung Cancer Care and Development of Liquid Biopsy-based Decision Support Models - LM² Study | NCT06105177 | Lung Cancer | 18 Years - | Catharina Ziekenhuis Eindhoven | ||
| Prognostic Value of Circulating Tumor DNA Dosing in Patients in Neoadjuvant Breast Neoplasia | NCT05050890 | Breast Neoplasm | ctDNA level dur... | 18 Years - | Instituto Brasileiro de Controle do Cancer | |
| LEVANTIS-0093A: GAGomes for Multi-Cancer Early Detection in High-Risk Adults (LEV93A) | NCT05295017 | Cancer | 55 Years - 80 Years | Elypta | ||
| A Proof of Concept Study of Pan-cancer Early Detection by Liquid Biopsy | NCT04972201 | Cancer | Multi-cancer ea... | 40 Years - 75 Years | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | |
| Early Onset Colorectal Cancer Detection | NCT06342401 | Colorectal Canc... Colorectal Neop... Colorectal Aden... Colorectal Canc... Colorectal Canc... Colorectal Canc... Colorectal Canc... Colorectal Neop... | ENCODE | 18 Years - 50 Years | City of Hope Medical Center | |
| Circulating DNA to Improve Outcome of Oncology PatiEnt. A Randomized Study | NCT04258137 | Colorectal Canc... Non Small Cell ... | Liquid biopsy | 18 Years - | Institut Bergonié | |
| Evaluation of Treatment Predictors Reflecting Beta-catenin Activation in Hepatocellular Carcinoma | NCT04965454 | Hepatocellular ... | Fluorine-18 flu... | 18 Years - | Queen's Medical Center | |
| Prevention of Colorectal Cancer Through Multiomics Blood Testing | NCT04369053 | Colon Cancer Rectal Cancer Colon Neoplasm Colon Diseases Colon Lesion Colon Polyp Colorectal Canc... Polyp Adenoma Rectal Diseases Gastrointestina... | Freenome test | 45 Years - 85 Years | Freenome Holdings Inc. | |
| Clinical, Translational and Biomarker-Based Female Genital HPV Induced Dysplasia and Cancer Screening Study Using Cf-HPV-DNA Blood Tests | NCT05536843 | Cervical Dyspla... Vaginal Dysplas... Vulvar Dysplasi... | 18 Years - 100 Years | University of Mississippi Medical Center | ||
| Development of a Biomarker to Predict the Efficacy of Anti-angiogenic Therapy in Ovarian Cancer | NCT05874115 | Epithelial Ovar... | liquid biopsy | 18 Years - | Centro di Riferimento Oncologico - Aviano | |
| Harvest of CTCs From MBC Patients Using the Parsortix™ PC1 System | NCT03427450 | Healthy Volunte... Breast Cancer, ... | Blood draw | 22 Years - | Angle plc | |
| Barrett's Esophagus and Esophageal Adenocarcinoma, Searching for Reliable Diagnostic RNA Plasma-based Biomarkers | NCT05688176 | Esophageal Neop... | 18 Years - | University Hospital, Ghent | ||
| Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening | NCT06122077 | Lung Cancer Dia... | blood draw | 50 Years - | Freenome Holdings Inc. | |
| Analysis of Circulating DNA in Blood Samples of Glioma-affected Patients | NCT05964153 | Glioma Circulating Tum... | Liquid Biopsy | 18 Years - | Corporacion Parc Tauli | |
| Neoadjuvant Lazertinib Therapy in EGFR-Mutation Positive Lung Adenocarcinoma Detected by BALF Liquid Biopsy | NCT05469022 | Non Small Cell ... | Neoadjuvant laz... | 19 Years - | Konkuk University Medical Center | |
| CIRculating CANcer MAster-Protocol | NCT05089747 | Adult With Soli... | Blood sampling ... | 18 Years - | Hospices Civils de Lyon | |
| Non-invasive Tumor Immunoglobulin Gene Next Generation Sequencing (IgNGS) in Diffuse Large B Cell Lymphoma (DLBCL) | NCT04237168 | Lymphoma, Large... | IgNGS from circ... | - | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | |
| Prospective Study on Resistance-associated Mutations in Metastatic Lung Cancer | NCT06081270 | Lung Cancer | Liquid biopsy | 18 Years - | University of Milano Bicocca | |
| Early Detection of Five Common Cancers Using the ctDNA Analysing Test | NCT05227261 | Cancer, Lung Cancer, Breast Cancer Liver Cancer, Colorec... Liquid Biopsy Circulating Tum... Cancer, Gastric | 40 Years - | Gene Solutions | ||
| Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening | NCT04273542 | Breast Cancer F... BRCA1 Mutation BRCA2 Mutation | liquid biopsy | 18 Years - | Centre Jean Perrin | |
| Circulating Tumor DNA in Patients Summoned for Colonoscopy; - a Liquid Biopsy for Detection, Characterization, Individualized Treatment and Follow-up of Colorectal Cancer | NCT06307938 | Colorectal Canc... Colorectal Aden... | liquid biopsy | 18 Years - | Helse Nord-Trøndelag HF | |
| Precision Medicine for Every Child With Cancer | NCT05504772 | Childhood Cance... Childhood Solid... Childhood Brain... Childhood Leuke... Refractory Canc... Relapsed Cancer | Whole Genome Se... RNA seq DNA Methylation Targeted Panel ... High Throughput... Patient Derived... Liquid Biopsy | 0 Years - 25 Years | Australian & New Zealand Children's Haematology/Oncology Group | |
| Osimertinib Treatment on EGFR T790M Plasma Positive NSCLC Patients (APPLE) | NCT02856893 | NSCLC | Osimertinib Gefitinib | 18 Years - | European Organisation for Research and Treatment of Cancer - EORTC | |
| Immune Resistance Interrogation Study | NCT04243720 | Cancer Solid Tumor Metastatic Canc... Immune Resistan... | 18 Years - | University Health Network, Toronto | ||
| AI-EMERGE: Development and Validation of a Multi-analyte, Blood-based Colorectal Cancer Screening Test | NCT03688906 | Colo-rectal Can... Cancer Colon Cancer, Rectum Neoplasms,Color... Polyps Polyp of Colon Adenoma Adenoma Colon | 18 Years - | Freenome Holdings Inc. | ||
| Implementation of Up-front ctDNA Into Lung Cancer Care and Development of Liquid Biopsy-based Decision Support Models - LM² Study | NCT06105177 | Lung Cancer | 18 Years - | Catharina Ziekenhuis Eindhoven | ||
| New Strategies to Detect Cancers in Carriers of Mutations in RB1 | NCT04164134 | Retinoblastoma Secondary Prima... | blood draw | 0 Years - 99 Years | Amsterdam UMC, location VUmc | |
| Early Onset Colorectal Cancer Detection | NCT06342401 | Colorectal Canc... Colorectal Neop... Colorectal Aden... Colorectal Canc... Colorectal Canc... Colorectal Canc... Colorectal Canc... Colorectal Neop... | ENCODE | 18 Years - 50 Years | City of Hope Medical Center | |
| NSCLC Heterogeneity in Early Stage Patients and Prediction of Relapse Using a Personalized "Liquid Biopsy" | NCT03771404 | Non Small Cell ... | blood sampling | 18 Years - | Hellenic Oncology Research Group | |
| Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!) | NCT05196087 | Breast Cancer Melanoma Gastrointestina... | 18 Years - | University Health Network, Toronto | ||
| Clinical Validation of an MCED Test in Symptomatic Populations (K-ACCELERATE) | NCT06391749 | Cancer Colon Cancer, Liver Cancer, Lung Cancer, Breast Cancer, Gastric | 18 Years - | Gene Solutions | ||
| A Validation Study to Determine Concordance of Liquid Biopsy and Breast Cancer Diagnosis | NCT06336928 | Breast Carcinom... | Non-Interventio... | 18 Years - | University of Southern California | |
| Evaluation Protocols for Isolation of Analytes From Urine for Future Oncology Applications | NCT05453604 | Breast Cancer Prostate Cancer Urine Liquid Biopsy | Colli-Pee UAS d... | 18 Years - | Novosanis NV | |
| Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors | NCT05383872 | Glioblastoma Glioma Liquid Biopsy | Focused Ultraso... | 18 Years - 80 Years | InSightec | |
| GUIDING MULTI-MODAL THERAPIES AGAINST MINIMAL RESIDUAL DISEASE BY LIQUID BIOPSIES | NCT06102889 | Pancreatic Aden... | liquid biopsy | 18 Years - | Karolinska University Hospital | |
| Liquid Biopsy in Hepatocellular Carcinoma | NCT04111029 | Hepatic Carcino... | Cell Free DNA | 18 Years - 70 Years | PGIMER | |
| Breast Cancer, Omics, and Precision Medicine | NCT04996836 | Breast Cancer | Next Generation... | 18 Years - | University of Campania "Luigi Vanvitelli" | |
| Evaluation Protocols for Isolation of Analytes From Urine for Future Oncology Applications | NCT05453604 | Breast Cancer Prostate Cancer Urine Liquid Biopsy | Colli-Pee UAS d... | 18 Years - | Novosanis NV | |
| The Correlation of PD-L1 Expression in Non-small Lung Cancer Tissue and Peripheral Blood T Cell and Serum. | NCT03073902 | NSCLC | Liquid biopsy | 18 Years - | Xinqiao Hospital of Chongqing | |
| Early Onset Colorectal Cancer Detection | NCT06342401 | Colorectal Canc... Colorectal Neop... Colorectal Aden... Colorectal Canc... Colorectal Canc... Colorectal Canc... Colorectal Canc... Colorectal Neop... | ENCODE | 18 Years - 50 Years | City of Hope Medical Center | |
| Clinical Research for the Consistency Analysis of PD-L1 in Cancer Tissue and Plasma Exosome | NCT02890849 | NSCLC | Liquid biopsy | - | Xinqiao Hospital of Chongqing | |
| Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors | NCT05383872 | Glioblastoma Glioma Liquid Biopsy | Focused Ultraso... | 18 Years - 80 Years | InSightec | |
| GENESIS: Genetic Biopsy for Prediction of Surveillance Intervals After Endoscopic Resection of Colonic Polyps | NCT02595645 | Colonic Polyps | Polypectomy and... | 18 Years - | University of Ulm | |
| Analysis of Whole Body Magnetic Resonance Imaging and Liquid Biopsy for Early Detection of Cancer in Patients With a Strong Family History of Cancer | NCT05868486 | Hematopoietic a... Malignant Solid... | Biospecimen Col... Genetic Testing... Liquid Biopsy Magnetic Resona... Survey Administ... | 18 Years - | City of Hope Medical Center | |
| Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus | NCT05918510 | Squamous Cell C... Carcinomas of U... High-risk Human... Liquid Biopsy Lymph Node Meta... Occult Tumor of... | Study of Viral ... | 18 Years - | Regina Elena Cancer Institute | |
| AssesSment of Early-deteCtion basEd oN liquiD Biopsy in Hepatobiliary Cancer Malignancies | NCT04835675 | Hepatobiliary M... | Multi-cancer ea... | 40 Years - 75 Years | Zhujiang Hospital | |
| Predicting Prostate Cancer in Elderly Men | NCT04079699 | Prostate Cancer... | Liquid Biopsy Standard biopsy | 70 Years - | Odense University Hospital | |
| Analysis of Whole Body Magnetic Resonance Imaging and Liquid Biopsy for Early Detection of Cancer in Patients With a Strong Family History of Cancer | NCT05868486 | Hematopoietic a... Malignant Solid... | Biospecimen Col... Genetic Testing... Liquid Biopsy Magnetic Resona... Survey Administ... | 18 Years - | City of Hope Medical Center | |
| Neoadjuvant Lazertinib Therapy in EGFR-Mutation Positive Lung Adenocarcinoma Detected by BALF Liquid Biopsy | NCT05469022 | Non Small Cell ... | Neoadjuvant laz... | 19 Years - | Konkuk University Medical Center | |
| Phenotypic Spectrum of CTCs in Tumors of the Female Reproductive System | NCT04817501 | Breast Cancer Ovarian Cancer Endometrial Can... | Taking 5 ml of ... Taking 5 ml EDT... | 18 Years - 80 Years | Tomsk National Research Medical Center of the Russian Academy of Sciences | |
| Feasibility of Cell-Free DNA Liquid Biopsy in Screening High-Risk Patients for Lung Cancer | NCT05384769 | Lung Carcinoma | Liquid Biopsy Low Dose Comput... Survey Administ... | 50 Years - 80 Years | City of Hope Medical Center | |
| NSCLC Heterogeneity in Early Stage Patients and Prediction of Relapse Using a Personalized "Liquid Biopsy" | NCT03771404 | Non Small Cell ... | blood sampling | 18 Years - | Hellenic Oncology Research Group | |
| Adjuvant TRastuzumab Deruxtecan for HER2-positive Gastroesophageal Cancer With Persistence of miNImal Residual Disease | NCT06253650 | Gastric Cancer HER2-positive G... | Experimental Control | 18 Years - | Gruppo Oncologico del Nord-Ovest | |
| LIQUIK: LIQUId Biopsy for Detection of Actionable Genomic BiomarKers in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) | NCT04703153 | Non Small Cell ... | 21 Years - | Lucence Health Inc. | ||
| Cell-free DNA Methylation for Epithelial Ovarian Cancer | NCT04651946 | Epithelial Ovar... DNA Methylation Benign Ovarian ... Training Set Validation Set Cell-free DNA Liquid Biopsy | DNA methylation... | 18 Years - | Peking Union Medical College Hospital | |
| Phenotypic Spectrum of CTCs in Tumors of the Female Reproductive System | NCT04817501 | Breast Cancer Ovarian Cancer Endometrial Can... | Taking 5 ml of ... Taking 5 ml EDT... | 18 Years - 80 Years | Tomsk National Research Medical Center of the Russian Academy of Sciences | |
| LEVANTIS-0087A: GAGomes for Multi-Cancer Early Detection in Asymptomatic Adults (LEV87A) | NCT05235009 | Cancer | Combined free G... | 18 Years - 80 Years | Elypta | |
| Liquid Biopsies and Imaging in Breast Cancer | NCT04223492 | Breast Cancer | Liquid biopsy Multi-parametri... | 18 Years - | UMC Utrecht | |
| Clinical Validation of an MCED Test in Symptomatic Populations (K-ACCELERATE) | NCT06391749 | Cancer Colon Cancer, Liver Cancer, Lung Cancer, Breast Cancer, Gastric | 18 Years - | Gene Solutions | ||
| A Prospective Feasibility Study Evaluating Extracellular Vesicles Obtained by Liquid Biopsy for Neoadjuvant Treatment Response Assessment in Rectal Cancer | NCT04852653 | Rectal Cancer Liquid Biopsy | Supplementary b... | 18 Years - | University Hospital, Bordeaux | |
| Neoadjuvant Lazertinib Therapy in EGFR-Mutation Positive Lung Adenocarcinoma Detected by BALF Liquid Biopsy | NCT05469022 | Non Small Cell ... | Neoadjuvant laz... | 19 Years - | Konkuk University Medical Center | |
| The Jinling Cohort | NCT06011694 | Cancer Multi Cancer Ea... Liquid Biopsy | MERCURY test, h... | 45 Years - 75 Years | Nanjing Shihejiyin Technology, Inc. | |
| Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus | NCT05918510 | Squamous Cell C... Carcinomas of U... High-risk Human... Liquid Biopsy Lymph Node Meta... Occult Tumor of... | Study of Viral ... | 18 Years - | Regina Elena Cancer Institute |
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