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Sulforaphane

Broccoli Sprout Extract Beverage: 600 micromole glucoraphanin and 40 micromole sulforaphane dissolved in 100 mL dilute pineapple and lime juice daily for 84 days.

Broccoli Sprout Extract Beverage

100 mL of dilute pineapple and lime juice daily for 84 days.

placebo beverage

Thomas W Kensler, PhD

This study is a 12 week placebo-controlled Phase II broccoli sprout intervention to be conducted in Qidong, P.R. China. One thousand two hundred people from the farming townships will be screened and three hundred eligible individuals will be enrolled in the study. Participants will be randomized into two treatment groups: one will receive a juice beverage containing glucoraphanin- and sulforaphane-rich broccoli sprout extract, pineapple juice, lime juice, and water and the other will receive a placebo beverage containing pineapple juice, lime juice and water. Participants will drink their assigned beverage every evening and provide biweekly urine samples and monthly blood samples. The principal endpoints of this study are pharmacokinetic evaluation of elimination of glucoraphanin/sulforaphane and their metabolites in urine and pharmacodynamic evaluation through measures of urinary levels of exposure biomarkers for dietary and air-borne toxins, which are known to be high in this population.

Broccoli Sprout Intervention in Qidong, P.R. China

Urinary excretion of benzene mercapturic acid (S-PMA) in 12 hour overnight void at 12 weeks

Micromoles of urinary sulforaphane metabolites excreted over 24 hours after consuming the 84th dose.

Johns Hopkins University

National Institute of Environmental Health Sciences (NIEHS)

Qidong Liver Cancer Institute

University of Pittsburgh

University of Minnesota

Johns Hopkins Bloomberg School of Public Health

Broccoli Sprout Extract Beverage : Broccoli Sprout Extract Beverage: 600 micromole glucoraphanin and 40 micromole sulforaphane dissolved in 100 mL dilute pineapple and lime juice daily for 84 days.

placebo beverage : 100 mL of dilute pineapple and lime juice daily for 84 days.

Placebo Beverage

Total

Age, Categorical

Age, Continuous

Sex: Female, Male

China

Region of Enrollment

Thomas W. Kensler, PhD

Analyses were conducted on all urine samples provided by study participants at week 12.

Effect of Treatment on Levels of Air Toxics Mercapturic Acids Over Intervention Period

placebo beverage: 100 mL of dilute pineapple and lime juice daily for 84 days.

Broccoli Sprout Extract Beverage: Broccoli Sprout Extract Beverage: 600 micromole glucoraphanin and 40 micromole sulforaphane dissolved in 100 mL dilute pineapple and lime juice daily for 84 days.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Broccoli Sprout Intervention in Qidong, P.R. China	NCT01437501	Environmental C...	Broccoli Sprout... placebo beverag...	21 Years - 65 Years	Johns Hopkins Bloomberg School of Public Health
Broccoli Sprout Intervention in Qidong, P.R. China	NCT01437501	Environmental C...	Broccoli Sprout... placebo beverag...	21 Years - 65 Years	Johns Hopkins Bloomberg School of Public Health
Broccoli Sprout Intervention in Qidong, P.R. China	NCT01437501	Environmental C...	Broccoli Sprout... placebo beverag...	21 Years - 65 Years	Johns Hopkins Bloomberg School of Public Health

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