Symptoms and General Pathology

All Conditions

Neoplasms

Skin and Connective Tissue Diseases

Pain, Postoperative

Breast Neoplasms

Pain

Breast Diseases

Skin Diseases

Adjuvants, Anesthesia

Analgesics

Central Nervous System Depressants

All Drugs and Chemicals

Anti-Inflammatory Agents

Antirheumatic Agents

Fentanyl

Ibuprofen

Bupivacaine

Anesthetics

Anesthetics, Local

Analgesics, Opioid

Narcotics

Anesthetics, Intravenous

Anesthetics, General

In group 30 ml, ESPB will be performed with patients in the lateral decubitus position while the surgical site up. US probe will be placed 2-3 cm lateral to the T4 transvers process. The block needle will be inserted cranio-caudal direction and then for correction of the needle 5 ml saline will be injected deep into the erector spina muscle fascia. Following confirmation of the correct position of the needle 30 ml %0.25 bupivacaine will be administered for block.

In group ESPB, ESPB will be performed with patients in the lateral decubitus position while the surgical site up. US probe will be placed 2-3 cm lateral to the T4 transvers process. The block needle will be inserted cranio-caudal direction and then for correction of the needle 5 ml saline will be injected deep into the erector spina muscle fascia. Following confirmation of the correct position of the needle 20 ml %0.25 bupivacaine will be administered for block.

Patients will be administered ibuprofen 400 mgr IV every 8 hours in the postoperative period. A patient controlled device prepared with 10 mcg/ ml fentanyl will be attached to all patients with a protocol included 10 mcg bolus without infusion dose, 10 min lockout time and 4 hour limit. Postoperative patient evaluation will be performed by an anesthesiologist blinded to the procedure.

Bupivacaine + Fentanyl

Postoperative pain is an important issue in female patients underwent breast surgery. Postoperative effective pain treatment provides early mobilization and shorter hospital stay. The US-guided erector spina plane block (ESPB) may be used for postoperative pain treatment following breast surgery. It is a relatively novel interfascial block that was defined by Forero et al. It has been reported that ESPB provides effective analgesia management for several breast surgeries.

Various methods may be performed to reduce the use of systemic opioids and for effective pain treatment following mastectomy and axillary dissection surgery. Ultrasound (US)-guided interfascial plane blocks have been used increasingly due to the advantages of ultrasound in anesthesia practice.

The US-guided erector spina plane block (ESPB) provides thoracic analgesia at T5 level and abdominal analgesia at T7-9 level. ESPB contains a local anesthetic injection into the deep fascia of erector spinae. Visualization of sonoanatomy is easy, and the spread of local anesthesic agents can be easily seen under the erector spinae muscle. Thus, analgesia occurs in several dermatomes with cephalad-caudad way. In the literature, it has been reported that ESP block provides effective analgesia after several surgeries such as open heart surgery, breast surgery, thoracoscopic and abdominal operations.

The aim of this study is to compare the efficacy of the different volumes of US-guided ESPB for postoperative analgesia after mastectomy and axillary dissection surgery. The primary aim is to compare postoperative opioid consumption, and the secondary aim is to evaluate pain scores (VAS), and adverse effects related with opioids (allergic reaction, nausea, vomiting).

There are two models for this study. The first group is 30 ml volume ESPB group. The second one is 20 ml volume ESPB group

The participant and the anesthesiologist who will perform postoperative pain evaluation and opioid consumption will not know the group

Female patients who will undergo breast surgery will be included

Different Volumes of Erector Spinae Plane Block for Breast Surgery

Erector Spinae Plane Block in Different Volumes on Postoperative Pain Control Following Breast Surgery: A Randomized, Prospective Study

The primary aim is to compare postoperative opioid (fentanyl) consumption on patient controlled analgesia device.

The parameters on PCA devices such as delivery and demand will be assessed

Postoperative pain assessment will be performed using the VAS score (0 = no pain, 10 = the most severe pain felt). The VAS scores will be recorded

Medipol University

Principal Investigator

Pharmaceutical Solutions

Group 1 (opioid group) will receive general endotracheal anesthesia augmented with an epidural. The epidural solution intraoperatively and post-operatively will contain fentanyl + bupivacaine titrated to appropriate surgical conditions and post-operative pain control.

Group 2 (local anesthetic group) will receive general endotracheal anesthesia augmented with an epidural. The epidural solution intraoperatively and post-operatively will contain bupivacaine titrated to appropriate surgical conditions and post-operative pain control.

General endotracheal anesthesia augmented with an epidural. The epidural solution intraoperatively and post-operatively will contain fentanyl + bupivacaine titrated to appropriate surgical conditions and post-operative pain control.

General endotracheal anesthesia augmented with an epidural. The epidural solution intraoperatively and post-operatively will contain bupivacaine titrated to appropriate surgical conditions and post-operative pain control

Roya Yumul, MD, PhD

The proposed study is a pilot prospective, single-blinded, randomized controlled trial evaluating the effects of two routine, standard-of-care, anesthetic techniques on natural killer cell population size and cytotoxicity in patients undergoing exploratory abdominal laparotomies.

Effects of Anesthetic Technique on NK Cells

Effects of Anesthetic Technique on Natural Killer Cell Population and Cytotoxicity

Cytotoxicity will be assessed using Flow Cytometric analysis of cell receptor expression.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Different Volumes of Erector Spinae Plane Block for Breast Surgery	NCT05232084	Breast Cancer Breast Neoplasm... Breast Diseases	Bupivacaine + F...	18 Years - 65 Years	Medipol University
Effects of Anesthetic Technique on NK Cells	NCT02669186	Pain Anesthesia Cancer	Bupivacaine + F... Bupivacaine	18 Years - 80 Years	Cedars-Sinai Medical Center
Effects of Anesthetic Technique on NK Cells	NCT02669186	Pain Anesthesia Cancer	Bupivacaine + F... Bupivacaine	18 Years - 80 Years	Cedars-Sinai Medical Center

Spots Global Cancer Trial Database for bupivacaine + fentanyl