Neoplasms

All Conditions

Digestive System Diseases

Rare Diseases

Carcinoma

Esophageal Neoplasms

Esophageal Cancer

The incidence of anastomotic leaks after gastroesophageal anastomosis after thoracolaparoscopic cancer esophagus surgery is high at the Oslo University Hospital. The patients selected for operation shall be investigated for microcirculatory changes at the thoracic anastomosis site and followed up for any post operative anastomotic leaks.

- Microcirculation shall be evaluated during the operation with trans serosal laser doppler flowmetry and visible light spectroscopy (LDFVLS). Different anatomical areas of the stomach and gastric tube shall be examined With LDFVLS to find any changes in SO2, rHb, flow, and velocity. Repeat measurements shall be taken to compare them with the baseline measurements.

Evaluation of the Circulatory Status of Stomach Tube and Gastrooesophageal Anastomosis

Impact of Circulatory Changes on Thoracic Anastomosis in Patients Undergoing Thoracolaparoscopic Surgery for Oesophageal Carcinoma

Repeated measurements of microcirculation With laser dopper flometer and visible light spectrometry shall be performed trans serosally of the stoach and gastric tube to register changes in microcirculation. Patients shall be followed up for anastomotic leaks. Besides CT angiography shall be performed before surgery.

Oslo University Hospital

Consultat Vascular Surgeon

Ear, Nose, and Throat Diseases

Deglutition Disorders

Esophageal Diseases

Gastrointestinal Diseases

Gastrointestinal Neoplasms

Digestive System Neoplasms

Head and Neck Neoplasms

Stent followed by 3 brachytherapy fractions

Self-expanding metal stents will be used. These will be of the type which the hospital at any given time uses, at present Ultraflex®.

Stent insertion

a flexible applicator (with a diameter adapted to the stent's diameter) will be introduced into the oesophagus, so the applicator will be lying in the middle of the lumen of the stent. Thereafter, the flexible applicator is connected to a MicroSelectron afterloading device (Iridium-192), and the treatment is given with a high dose rate (\> 12 Gy/h).

Brachytherapy

a flexible applicator will be introduced into the oesophagus. The flexible applicator is connected to a MicroSelectron afterloading device (Iridium-192), and the treatment is given with a high dose rate (\> 12 Gy/h).

Kristin Bjordal, PhD

We wish to improve the swallowing function of patients with advanced cancer of the oesophagus, by carrying out a randomised clinical study in which we compare primary stenting followed by brachytherapy in the stent, 8 G x 3 with standard brachytherapy 8 Gy x 3.

The aim of the study is to investigate whether patients who receive a stent followed by brachytherapy have a better swallowing function without more pain at week +2,compared to patients who receive brachytherapy alone.

Palliation Dysphagia Cancer Oesophagus Stent+Brachytherapy Versus Brachytherapy Only

Palliation of Dysphagia in Patients With Advanced Cancer of the Oesophagus by Comparing Stent Followed by 3 Courses of Brachytherapy With 3 Courses of Brachytherapy Only. A Randomised Phase III Study (PACO)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of the Circulatory Status of Stomach Tube and Gastrooesophageal Anastomosis	NCT03724162	Circulatory; Ch... Microcirculatio...		-	Oslo University Hospital
Evaluation of the Circulatory Status of Stomach Tube and Gastrooesophageal Anastomosis	NCT03724162	Circulatory; Ch... Microcirculatio...		-	Oslo University Hospital
Palliation Dysphagia Cancer Oesophagus Stent+Brachytherapy Versus Brachytherapy Only	NCT00653107	Esophageal Neop...	Stent insertion Brachytherapy Brachytherapy	18 Years -	Oslo University Hospital

Spots Global Cancer Trial Database for cancer oesophagus