Neoplasms

All Conditions

Digestive System Diseases

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Blood and Lymph Conditions

Rare Diseases

Carcinoma

Carcinoma, Hepatocellular

Cholangiocarcinoma

Urinary Bladder Neoplasms

Lymphadenopathy

Gallbladder Neoplasms

Adenocarcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Lymphatic Diseases

Biliary Tract Neoplasms

Biliary Tract Diseases

Gallbladder Diseases

Bile Duct Cancer

Gallbladder Cancer

the use of unilateral stent insertion in malignant hilar obstruction for using endoscopic retrograde cholangiopancreatography(ERCP)

the use of bilateral stent insertion in malignant hilar obstruction for using endoscopic retrograde cholangiopancreatography(ERCP)

to use a LCD stent at an unilateral or bilateral stent insertion

stent insertion

to use ERCP for a stent insertion in an obstructive biliary tract

Endoscopic retrograde cholangiopancreatoscopy(ERCP)

Kwang hyuck Lee, PhD

Internal biliary drainage is an useful method for a control of jaundice and cholangitis to patients who had a malignant hilar obstruction due to hepatocellular carcinoma, cholangiocarcinoma, gall bladder cancer or metastatic lymphadenopathy.

Bilateral biliary drainage is more physiologic but technically difficult to compared with unilateral biliary drainage specially related to conformability and flexibility between using stents.

There are no prospective clinical trials compared with these internal biliary drainage methods in hilar malignant obstruction using metal stent.

Therefore, the investigators want to compare the clinical outcome of two method: Unilateral biliary stent and Bilateral biliary stent

Comparison Between Unilateral Versus Bilateral Stenting for Malignant Hilar Biliary Obstruction to Use a LCD Stent

Comparison Between Unilateral Versus Bilateral Stenting for Malignant Hilar Biliary Obstruction to Use a Large Cell Niti-S (LCD) Stent

Participants will followed after stent insertion and observe a complication rate between two groups.

Participants will followed for the new obstruction(new jaundice) will occur.

Kwang Hyuck Lee

Professor

Ear, Nose, and Throat Diseases

Esophageal Neoplasms

Deglutition Disorders

Esophageal Diseases

Head and Neck Neoplasms

Esophageal Cancer

Stent followed by 3 brachytherapy fractions

Self-expanding metal stents will be used. These will be of the type which the hospital at any given time uses, at present Ultraflex®.

Stent insertion

a flexible applicator (with a diameter adapted to the stent's diameter) will be introduced into the oesophagus, so the applicator will be lying in the middle of the lumen of the stent. Thereafter, the flexible applicator is connected to a MicroSelectron afterloading device (Iridium-192), and the treatment is given with a high dose rate (\> 12 Gy/h).

Brachytherapy

a flexible applicator will be introduced into the oesophagus. The flexible applicator is connected to a MicroSelectron afterloading device (Iridium-192), and the treatment is given with a high dose rate (\> 12 Gy/h).

Kristin Bjordal, PhD

We wish to improve the swallowing function of patients with advanced cancer of the oesophagus, by carrying out a randomised clinical study in which we compare primary stenting followed by brachytherapy in the stent, 8 G x 3 with standard brachytherapy 8 Gy x 3.

The aim of the study is to investigate whether patients who receive a stent followed by brachytherapy have a better swallowing function without more pain at week +2,compared to patients who receive brachytherapy alone.

Palliation Dysphagia Cancer Oesophagus Stent+Brachytherapy Versus Brachytherapy Only

Palliation of Dysphagia in Patients With Advanced Cancer of the Oesophagus by Comparing Stent Followed by 3 Courses of Brachytherapy With 3 Courses of Brachytherapy Only. A Randomised Phase III Study (PACO)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Comparison Between Unilateral Versus Bilateral Stenting for Malignant Hilar Biliary Obstruction to Use a LCD Stent	NCT01875549	Obstruction of ... Cholangiocarcin... Hepatocellular ... Malignant Lymph... Gall Bladder Ca...	stent insertion Endoscopic retr...	18 Years -	Samsung Medical Center
Comparison Between Unilateral Versus Bilateral Stenting for Malignant Hilar Biliary Obstruction to Use a LCD Stent	NCT01875549	Obstruction of ... Cholangiocarcin... Hepatocellular ... Malignant Lymph... Gall Bladder Ca...	stent insertion Endoscopic retr...	18 Years -	Samsung Medical Center
Palliation Dysphagia Cancer Oesophagus Stent+Brachytherapy Versus Brachytherapy Only	NCT00653107	Esophageal Neop...	Stent insertion Brachytherapy Brachytherapy	18 Years -	Oslo University Hospital

Spots Global Cancer Trial Database for stent insertion