Neoplasms

All Conditions

Digestive System Diseases

Symptoms and General Pathology

Carcinoma

Carcinoma, Hepatocellular

Disease Progression

Disease Attributes

Hematinics

All Drugs and Chemicals

Liver Extracts

Perform hepatectomy with conventional method for HCC patients.

The new technique of rapid ligating the corresponding inflow and outflow vessels without hills dissection before parenchyma transection during hepatectomy.

A Simple Technique of Rapid Ligating the Corresponding Inflow and Outflow Vessels Without Hilus Dissection During Hepatectomy

hepatectomy (conventional method)

hepatectomy (rapid ligating)

Xiaoping Chen, M.D.

Binhao Zhang, M.D.

This study examines the role of this simple technique on postoperative metastasis and long term survival.

The only hope of long-term survival for patients with primary hepatocellular carcinoma (HCC) is surgical resection or liver transplantation, the former of which is more feasible at present. However, postoperative recurrence or metastasis is an ominous feature for this disease. Innovation of the surgical procedure for improving prognosis is under emergency request. This study examines the role of this simple technique on postoperative metastasis and long term survival.

During the past 20 years, more 600 patients with primary HCC were performed hepatectomy with the new hemorrhage control technique, and prospective randomized controlled trial (RCT) was applied. We further applied a mice model ligating the pedicle of the lesion-located hepatic lobe before hepatectomy to imitate the clinic practice, and evaluated the role of the new technique on postoperative metastasis and survival.

Rapid Ligating the Corresponding Inflow and Outflow Vessels Without Hilus Dissection During Hepatectomy

to examine if there is intrahepatic recurrence

to examine if there is intrahepatic metastasis and metastasis in distant organs

intraoperative death， and death in one month after surgery

to check the 5 years overall survival (OS) and disease free survival (DFS)

Huazhong University of Science and Technology

professor

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Prostatic Neoplasms

Body Weight

Weight Loss

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

A healthful diet plus exercise intervention to promote a weight loss of up to 2 pounds/week

This arm will receive the same diet and exercise intervention as the experimental arm once recovery from prostatectomy is achieved.

Both arms will receive the same intervention: a healthful diet plus exercise intervention to promote a weight loss of up to 2 pounds/week. The only difference is the timing of the delivery of the intervention (immediate vs. delayed).

Immediate diet and exercise intervention

Delayed diet and exercise intervention

Wendy Demark-Wahnefried, PhD, RD

RATIONALE: Obesity and overweight are associated with the risk of aggressive disease, and energy balance may play a major role in prostate cancer progression.

PURPOSE: Randomized phase II trial to study the effectiveness of weight loss, via a healthy energy-restricted diet and exercise, in slowing or preventing disease progression in patients who have newly diagnosed prostate cancer.

This is a 2-arm randomized controlled feasibility trial among 40 overweight or obese men newly diagnosed with prostate cancer who are scheduled for prostatectomy. This study will use the presurgical period to explore the potential impact of weight loss via a healthy energy-restricted diet and increased physical activity on circulating hormones, cytokines, and growth factors, as well as effects on tumor biology and other clinical outcomes. Consenting patients will be block randomized to 1-of-2 study arms: 1) a healthful diet + exercise intervention to promote a weight loss of up to 2 pounds/week; or 2) a wait-list control who will receive the intervention once the study period is complete. Both groups will receive nutritional counseling during the study period to correct nutritional deficiencies with food sources. This study will explore and contrast changes in body mass index (BMI) observed over the study period (minimum of 3.5 weeks) in the intervention vs. wait-list control arms, and also monitor changes in body composition, energy intake and physical activity; these changes will be studied in relation to the following endpoints: a) changes in select circulating biomarkers and gene expression related to cancer progression, hormonal status, inflammation and other energy-related factors; b) rates of tumor proliferation and apoptosis; c) tumor immunohistochemical markers of insulin receptor, vascular endothelial growth factor (VEGF), AKT, and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB); and d) functional and health-related outcomes, i.e., side-effects and medical outcomes, quality of life (QoL), and functional status.

Improving Energy Balance in Men With Prostate Cancer

Exploring the Impact of Negative Energy Balance in Men With Prostate Cancer

Changes in tumor proliferation rate (Ki-67) over the presurgical study period (minimum of 3.5 weeks, up to 24 weeks) will be explored and compared between the intervention and wait-list control arms.

Changes in body composition, energy intake and physical activity over the presurgical study period (minimum of 3.5 weeks, up to 24 weeks) will be explored and compared between the intervention and wait-list control arms.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Rapid Ligating the Corresponding Inflow and Outflow Vessels Without Hilus Dissection During Hepatectomy	NCT02319863	Cancer Progress...	hepatectomy (co... hepatectomy (ra...	18 Years - 65 Years	Huazhong University of Science and Technology
Rapid Ligating the Corresponding Inflow and Outflow Vessels Without Hilus Dissection During Hepatectomy	NCT02319863	Cancer Progress...	hepatectomy (co... hepatectomy (ra...	18 Years - 65 Years	Huazhong University of Science and Technology
Improving Energy Balance in Men With Prostate Cancer	NCT01886677	Prostate Cancer	Immediate diet ... Delayed diet an...	19 Years -	University of Alabama at Birmingham

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