Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

Antineoplastic Agents

All Drugs and Chemicals

Micronutrients

Hematinics

Vitamins

Paclitaxel

Carboplatin

Etoposide

Pemetrexed

Albumin-Bound Paclitaxel

Cisplatin

Fluzoparib

Etoposide phosphate

Tubulin Modulators

Antimitotic Agents

Enzyme Inhibitors

Folic Acid

Vitamin B Complex

Folic Acid Antagonists

Poly(ADP-ribose) Polymerase Inhibitors

Folinic Acid

Folate

Vitamin B9

Camrelizumab

Cisplatin 75mg/m2 IV and Pemetrexed 500mg/m2 IV Q3W (Day 1 of each cycle of cycles 1-3) (non-squamous cell carcinoma only)

Cisplatin，Pemetrexed

Cisplatin 50mg/m2 IV (the 1st and 8th days of the 1st cycle and the 2nd cycle; the 8th and 15th days of the 3rd cycle); Etoposide 50mg/m2 IV (the 1st cycle And the 1st to the 5th day of the 2nd cycle; the 8th to the 12th day of the 3rd cycle).

Cisplatin，Etoposide

Carboplatin AUC=6, Albumin Paclitaxel 100mg/m2 IV; Days 1, 8 and 15 of cycles 1, 2, and 3.

Carboplatin, Albumin Paclitaxel

Radiotherapy

Liu ningbo, PhD

Liu ningbo

Fluzoparib combined with Camrelizumab for maintenance treatment of locally advanced non-small cell lung cancer after concurrent radiotherapy and chemotherapy

Fluzoparib Combined With Camrelizumab for Maintenance Treatment of Locally Advanced Non-small Cell Lung Cancer

Fluzoparib Combined With Camrelizumab for Maintenance Treatment of Locally Advanced Non-small Cell Lung Cancer After Concurrent Chemotherapy and Radiotherapy. A Single-arm, Single-center, Phase II Clinical Study

PFS is defined as the time from randomization to the first documented disease progression or death due to any cause, whichever occurs first.

ORR is defined as the percentage of participants who have achieved a Complete Response (CR) or a Partial Response (PR)

Disease control rate is the proportion of patients whose tumors have shrunk or stabilized for a certain period of time, including complete remission (CR), partial remission (PR) and stable (SD) cases

OS was defined as the time from randomization to death due to any cause. OS is presented. Censoring will be performed using the date of last known contact for those who are alive at the time of analysis.

Number of participants with treatment-related adverse events as assessed by CTCAE v4.0

Tianjin Medical University Cancer Institute and Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Fluzoparib Combined With Camrelizumab for Maintenance Treatment of Locally Advanced Non-small Cell Lung Cancer	NCT04828395	Non-small Cell ...	Camrelizumab Fluzoparib Cisplatin，Pemet... Cisplatin，Etopo... Carboplatin, Al... Radiotherapy	18 Years -	Tianjin Medical University Cancer Institute and Hospital
Fluzoparib Combined With Camrelizumab for Maintenance Treatment of Locally Advanced Non-small Cell Lung Cancer	NCT04828395	Non-small Cell ...	Camrelizumab Fluzoparib Cisplatin，Pemet... Cisplatin，Etopo... Carboplatin, Al... Radiotherapy	18 Years -	Tianjin Medical University Cancer Institute and Hospital

Spots Global Cancer Trial Database for carboplatin, albumin paclitaxel