Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Carcinoma

Endometrial Neoplasms

Uterine Cervical Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Uterine Cervical Diseases

Radiation therapy

Akila Viswanathan, MD, MPH

The purpose of this study is to investigate the effect of certain variables such as the fullness of the patients bladder and the position of the treatment applicator on the dose of radiation that other organs such as the bladder and the rectum receive during radiation treatment for endometrial carcinoma.

* This study is separated into 2 phases. In phase 1, patients will be asked to have their bladder full for the second planned insertion of the brachytherapy applicator and empty for the third insertion. For phase 2, the effect of cylinder angle on normal tissue dosimetry will be investigated. Of the two bladder states assessed in phase 1 (empty or full), the one deemed to give the lower dose to the total amount of bladder tissue will be considered the standard and applied to all patients in phase 2.
* In phase 1, to standardize bladder filling, patients will be asked to empty their bladder, then to drink 32 oz of water one and a half hours before the CT scan. The patient will undergo a treatment-planning scan after the brachytherapy cylinder is inserted and before brachytherapy treatment.
* In phase 2, patients will be asked to fill or empty their bladder according to the results of phase 1. The vaginal cylinder will be placed horizontally for the second treatment. The cylinder will then be angled at a specific angle for the subsequent treatment.
* A history and physical exam will be performed within 2 weeks of study entry, then at 14 days, 90 days, and 180 days following the completion of therapy.

Dosimetric Analysis of Vaginal Cuff Brachytherapy in Endometrial Carcinoma

Brigham and Women's Hospital

Dana-Farber Cancer Institute

Akila Viswanathan, MD

Rare Diseases

Vaginal Neoplasms

Vulvar Neoplasms

Vulvar Diseases

Vaginal Diseases

Vaginal Cancer

Vulvar Cancer

Brachytherapy

Akila N Viswanathan, MD, MPH

The primary goal of this pilot study is to assess the feasibility of using magnetic resonance (MR) imaging guidance in the Magnetic Resonance Therapy (MRT) unit at the Brigham and Women's Hospital during the implantation of brachytherapy applicators in patients with gynecologic malignancies. Patients with gynecologic malignancies requiring brachytherapy are currently treated under either fluoroscopic or CT visualization of the brachytherapy applicator. Magnetic resonance imaging has been shown in many studies to provide superior visualization of the cervix, vagina and uterus compared to CT. However no prior study has examined the feasibility of using real-time magnetic resonance imaging to assist in the guidance of gynecologic brachytherapy applicators

The primary endpoint involves the ability of the MRT guided procedure to protect bladder and rectal tissues from inadvertent insertion of the interstitial needles used to deliver brachytherapy. MR images obtained on the MRT unit should provide clear delineation of the bladder and rectum and allow for greater accuracy and avoidance of these normal tissues upon interstitial needle insertion. CT images will be obtained following the insertion of needles using the MRT unit. The procedure will be considered a failure if CT imaging identifies the insertion of needles into the bladder or rectum that was not detected using MR. Secondary endpoints include the ability of MR imaging to accurately reconstruct dosimetric plans and to construct dose volume histograms after the implantation of interstitial needles as well as the ability of MR imaging to accurately determine tumor, bladder and rectal volumes. Secondary endpoints will also include the assessment of acute skin, genitourinary and gastrointestinal toxicities as well as an assessment of tumor progression or recurrence during a 180 day follow-up period.

Magnetic Resonance Imaging Guided Gynecologic Brachytherapy

Pilot Study of Magnetic Resonance Imaging Guided Brachytherapy

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Dosimetric Analysis of Vaginal Cuff Brachytherapy in Endometrial Carcinoma	NCT00165126	Endometrial Car... Cervix Cancer Carcinoma of th...	Radiation thera...	18 Years - 90 Years	Dana-Farber Cancer Institute
Magnetic Resonance Imaging Guided Gynecologic Brachytherapy	NCT00112307	Cervix Neoplasm... Uterine Neoplas... Vaginal Neoplas... Vulvar Neoplasm...	Brachytherapy	18 Years -	Brigham and Women's Hospital
Dosimetric Analysis of Vaginal Cuff Brachytherapy in Endometrial Carcinoma	NCT00165126	Endometrial Car... Cervix Cancer Carcinoma of th...	Radiation thera...	18 Years - 90 Years	Dana-Farber Cancer Institute

Spots Global Cancer Trial Database for carcinoma of the uterus