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maximize stroke volume, and maintain cardiac index and stroke volume variation during the whole operation

keep cardiac index (CI) ≥ 2.2, and maintain CI and stroke volume variation during the whole operation

According to Frank-Starling law, the investigator will administer Voluven 6% 250 mL every 5 minute until stroke volume maximized (stabilized for 20 minutes), and maintain cardiac index and stroke volume variation during the whole operation.

Cardiac Output Maximization

The investigator will administer intravenous fluids to keep cardiac index (CI) ≥ 2.2, and maintain CI and stroke volume variation during the whole operation.

Cardiac Output Normalization

Ya-jung Cheng, M.D., Ph.D

Anesthetic management and fluid therapy is crucial in esophageal resection and reconstruction, which is associated with high incidence of postoperative morbidity and mortality. This study aims to investigate the effect of goal directed fluid management on the postoperative outcome of esophageal resection and reconstruction.

Anesthetic management and fluid therapy is crucial in esophageal resection and reconstruction, which is associated with high incidence of postoperative morbidity and mortality. Excessive fluid administration may result in pulmonary complication, while extremely hypovolemia may lead to shock, circulatory dysfunction, and renal damage. Little is known about fluid status will have impact on anastomotic leakage. Goal-directed fluid therapy has shown to benefit perioperative outcome in major abdominal surgery. This study aims to investigate the effect of goal directed fluid management on the postoperative outcome of esophageal resection and reconstruction.

Different Anesthetic Managements of Esophageal Resection and Reconstruction

The Effects of Different Anesthetic Managements on Inflammation, Oxidative Injuries, and Major Organ Complications: a Prospective Investigations on Esophageal Reconstruction and Intraoperative Shock

Perioperative mortality, anastomotic leakage, pneumonia, respiratory failure, renal dysfunction, and surgical site infection

Incidence of intraoperative shock, use of vasopressor or inotropic agents

Intensive care unit length of stay and hospital stay

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Different Anesthetic Managements of Esophageal Resection and Reconstruction	NCT02961140	Anesthesia Esophagus Cance... Postoperative C...	Cardiac Output ... Cardiac Output ...	35 Years - 65 Years	National Taiwan University Hospital
Different Anesthetic Managements of Esophageal Resection and Reconstruction	NCT02961140	Anesthesia Esophagus Cance... Postoperative C...	Cardiac Output ... Cardiac Output ...	35 Years - 65 Years	National Taiwan University Hospital
Different Anesthetic Managements of Esophageal Resection and Reconstruction	NCT02961140	Anesthesia Esophagus Cance... Postoperative C...	Cardiac Output ... Cardiac Output ...	35 Years - 65 Years	National Taiwan University Hospital

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