Symptoms and General Pathology

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Neoplasms

Diseases and Abnormalities at or Before Birth

Rare Diseases

Syndrome

Pneumothorax

Cysts

Birt-Hogg-Dube Syndrome

Pleural Diseases

Respiratory Tract Diseases

Neoplastic Syndromes, Hereditary

Genetic Diseases, Inborn

Primary Spontaneous Pneumothorax

Patients who were treated for spontaneous pneumothorax in Rijnstate hospital. "Interventions": visit to out-patient clinic,CT scan of pulmones.

Patients who were treated for spontaneous pneumothorax in Rijnstate hospital. "Interventions": withdrawal of blood sample for DNA analyses,

A low dose CT scan of the thorax (2mSv) wil be performed once.

CT scan of the thorax

A venous punction in order to withdraw 16ml blood is undertaken once.

blood sample for FLCN mutation analyses

Jincey D. Sriram, MD, MSc

Hans JM Smit, MD,PhD

Hans JM Smit, MD. PhD

Jincey Sriram, MD

Pieter E. Postmus, MD, PhD

Hans JM Smit, MD, PhD

To assess the prevalence of BHD (Birt-Hogg-Dubé syndrome) among patients with spontaneous pneumothorax. Patients who were treated for primary spontaneous pneumothorax in Rijnstate hospital are to be included. Patients will receive a questionnaire. When given consent, the investigators will invite them for a one-time visit to the out-patient clinic. Patients will be asked for a blood sample to determine pathogenic FLCN (folliculin) mutations and a pulmonary CT scan for evaluation of presence of lung cysts.

Based on the results of the pilot study in VUmc \*Free University Medical Center), in which 3 out of 40 tested patients had a pathological FLCN mutation, the investigators decided to extend the study to a second center; Rijnstate Hospital Arnhem. In this hospital a retrospective search was performed; patients who were treated for primary spontaneous pneumothorax were included. In the dossiers the investigators searched for medical history, pneumothorax side and recurrence, diagnostic imaging, treatment, co-morbidity, complications of treatment, skin abnormalities, kidney disease, smoking behavior, medication, and familial incidence of pneumothorax and other diseases. Patients will receive a letter with explanation of the research and a questionnaire in which the investigators ask them their about the medical status, co-morbidity, pneumothorax (number and side), smoking behavior, use of drugs, familial incidence of pneumothorax and other diseases.

The population will be formed out of patients who have returned the fully filled in questionnaire and who have given permission to receive information for further research. This further information will consist of an information letter on BHD syndrome and a consent form for a one-time visit to the out-patient clinic of Rijnstate hospital. Investigators expect that about 200 patients will return the fully filled in questionnaire and give their consent for further research. In a one-time visit in out-patient clinic, there will be given personal information on BHD syndrome and there will be performed physical examination for finding fibrofolliculomas. A pulmonary CT scan for evaluation of presence of lung cysts will be performed. Two samples of venous blood will be collected to access information on DNA diagnostics for pathogenic FLCN mutations. These are associated with the BHD syndrome. This last diagnostic testing will be performed in VUmc (Vrije Universiteit medisch centrum or Free University Medical Centre).

Prevalence of Spontaneous Pneumothorax in BHD

Prevalence of Birt-Hogg-Dubé Syndrome Among Patients With (Hereditary) Spontaneous Pneumothorax

Prof. Dr. Jaap Swieringa stichting

Mr. Willem Bakhuys Roozeboomstichting

Rijnstate Hospital

Hans Smit

MD, PhD

Blood and Lymph Conditions

Immune System Diseases

Hodgkin Disease

Lymphoma

Neoplasms by Histologic Type

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Hodgkin Lymphoma

Lymphosarcoma

Antineoplastic Agents

All Drugs and Chemicals

Bleomycin

Carbon Monoxide

Tests include; total lung capacity, vital capacity, functional residual capacity, forced vital capacity, forced expiratory volume in 1 second, carbon monoxide diffusing capacity, pulse oximetry before and after a 6 minute walk and Pulmonary Status and Dyspnea Questionnaire

Pulmonary Function Tests

Obtained at different time points during the study depending upon standard of care chemotherapy treatment

CAT Scan

Andrea K. Ng, MD, MPH

The purpose of this study is to find out the impact Bleomycin-containing chemotherapy, given with or without chest radiation therapy, on patients' lung function over time.

* The tests and procedures in this study are part of regular cancer care but this study offers more structured timing of these standard tests.
* Due to the potential lung toxicity associated with bleomycin-based chemotherapy, pulmonary function tests are routinely performed. Pulmonary function tests will be performed by a licensed, registered respiratory therapist and performed prior to the beginning of treatment, between the chemotherapy and radiation therapy (only for patients receiving both chemotherapy and radiation therapy), and at approximately 1 month, 6 months, 1 year and 2 years after the completion of all treatments.
* A CAT scan will be performed prior to the beginning of treatment, and approximately 1 month, 6 months, 1 year and 2 years after the completion of all treatments.
* A self-administered questionnaire will be performed on the days the patient is undergoing pulmonary function tests.

Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy

A Prospective Study of Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy With or Without Mediastinal Irradiation

Brigham and Women's Hospital

Dana-Farber Cancer Institute

Principal Investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Prevalence of Spontaneous Pneumothorax in BHD	NCT02916992	Spontaneous Pne...	CT scan of the ... blood sample fo...	18 Years -	Free University Medical Center
Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy	NCT00165438	Hodgkin's Disea...	Pulmonary Funct... CAT Scan	18 Years -	Dana-Farber Cancer Institute
Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy	NCT00165438	Hodgkin's Disea...	Pulmonary Funct... CAT Scan	18 Years -	Dana-Farber Cancer Institute
Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy	NCT00165438	Hodgkin's Disea...	Pulmonary Funct... CAT Scan	18 Years -	Dana-Farber Cancer Institute

Spots Global Cancer Trial Database for cat scan

Every month we try and update this database with for cat scan cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for cat scan

Every month we try and update this database with for cat scan cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for cat scan cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.