Neoplasms

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Liver Extracts

preop portal vein embolization + stem cells infusion

CD133+ infusion

portal vein embolization

Treatment of patients with metastatic colorectal carcinoma is surgical resection. Only 10-15% of the patients will be candidates for curative resection. After response to chemotherapy this figure rises 10-13% more. To perform the surgery it is necessary to have a sufficient remnant liver volume (RLV), which allows maintaining optimal liver function after resection. If the estimated RLV is insufficient preoperatively, portal venous embolization site (PVE) is performed for compensatory hypertrophy, thus increasing the number of resections 19%. Still, in 20% of these patients surgery can not be performed because RLV is not achieved or because the disease progresses while waiting for growth. Therefore, it is necessary to improve liver regeneration without promoting tumor growth. Studies on liver regeneration, have determined that cells (CD133 +) are involved in the liver hypertrophy that occurs after hepatectomy. CD133 + have been used to induce liver hypertrophy with encouraging results. This population of CD133 +, can be selected from peripheral blood after stimulation with Granulocyte colony-stimulating factor (G-CSF), being able to obtain a large number of them. The investigators propose to treat patients who do not meet criteria for surgery because of insufficient volume \<40%, with CD133 + and portal embolization in order to carry out a surgical resection in a second place.

Cd133+ Cell Infusion in Patients With Colorectal Liver Metastases.

Cd133+ Cell Infusion in Patients With Colorectal Liver Metastases That Are Going to be Submitted to a Major Liver Resection

Liver volume estimated by computed tomography

Hospital San Carlos, Madrid

Principal investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Cd133+ Cell Infusion in Patients With Colorectal Liver Metastases.	NCT03803241	Colorectal Canc...	CD133+ infusion portal vein emb...	18 Years - 80 Years	Hospital San Carlos, Madrid
Cd133+ Cell Infusion in Patients With Colorectal Liver Metastases.	NCT03803241	Colorectal Canc...	CD133+ infusion portal vein emb...	18 Years - 80 Years	Hospital San Carlos, Madrid

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