Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Symptoms and General Pathology

Lung Neoplasms

Carcinoma, Non-Small-Cell Lung

Carcinoma

Neoplastic Cells, Circulating

Carcinoma, Bronchogenic

Bronchial Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Neoplasm Metastasis

Neoplastic Processes

Yi-Long Wu, MD

Primary endpoint To observe the dynamic changes of CTC during the process of platinum based chemotherapy in advanced NSCLC.

To study the relationship between CTC count and clinical outcome of chemotherapy (ORR and PFS).

Secondary endpoint To study the relationship between CTC and overall survival. To study the molecular feature of CTC, such as epidermal growth factor receptor (EGFR), KRAS, CD117, etc.

This is a prospective observational non-intervention study evaluating the dynamic CTC count during the chemotherapy. Patients provide written informed consent and pass the screening. Peripheral blood will be drawn before and after the first line chemotherapy. Analyze the relationship between CTC count and clinical outcome. The time points of blood drawing are set as following: once prior to 1st cycle of chemotherapy, once 1 week prior to 2nd cycle of chemotherapy, posterior to 4th cycle (or less than 4th cycle) of chemotherapy and once when progressive disease (PD). The specific blood tube CellSave Tube will be used, 7.5ml blood sample every time. One follow-up (including by phone) be made every 3 month after PD until death. The clinical outcome of first line chemotherapy will be ultimately obtained.

The DNA sample will be rtetained for molecular analysis such as EGFR, KRAS, etc.

Dynamic Circulating Tumor Cell (CTC) Changes During the Chemotherapy in NSCLC

A Prospective Observational Study on the Dynamic Changes of CTC Enumeration in Advanced NSCLC With 1st Line Chemotherapy

Guangdong Association of Clinical Trials

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Dynamic Circulating Tumor Cell (CTC) Changes During the Chemotherapy in NSCLC	NCT01740804	Carcinoma, Non-... Cell, Circulati...		18 Years -	Guangdong Association of Clinical Trials
Dynamic Circulating Tumor Cell (CTC) Changes During the Chemotherapy in NSCLC	NCT01740804	Carcinoma, Non-... Cell, Circulati...		18 Years -	Guangdong Association of Clinical Trials

Spots Global Cancer Trial Database for cell, circulating tumor