Neoplasms

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Symptoms and General Pathology

Rare Diseases

Carcinoma

Carcinoma, Non-Small-Cell Lung

Lung Diseases, Obstructive

Carcinoma, Small Cell

Lung Neoplasms

Lung Diseases

Pulmonary Emphysema

Emphysema

Thoracic Diseases

Respiratory Tract Diseases

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Carcinoma, Bronchogenic

Bronchial Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Pulmonary Disease, Chronic Obstructive

Chronic Disease

Disease Attributes

Chronic Graft Versus Host Disease

Biopsy samples will be taken as a 2mm x 2cm excision of a wedge of skin at the edge of the incision during your surgery at the Mayo Clinic Rochester. Such excisions are frequently done as part of routine skin closure for optimal skin cosmesis following the surgical procedure.

Skin Biopsy

Dennis A Wigle, MD, PhD

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, the investigators will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells.

A Phase I Study of iPS Cell Generation From Patients With COPD

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, we will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells. Markers of induced pluripotent phenotype will be utilized to assess successful reprogramming.

Mayo Clinic

M.D., P.h.D.

Wounds and Injuries

Chronic Pain

Pain

Surgical Wound

Nerve section of intercostal nerve during surgery

Intercostal nerve is divided during surgery

Nerve section

Kim Wildgaard, MD

Henrik Kehlet, MD, Phd, Pro

The purpose of this study is to investigate if controlled nerve section reduces chronic pain after thoracotomy.

Evaluation of Chronic Pain After Nerve Section During Thoracotomy

Post Thoracotomy Pain After Nerve Section

Rigshospitalet, Denmark

MD Kim Wildgaard

Multiple Pulmonary Nodules

Solitary Pulmonary Nodule

The study scan, s-DCT and correction scan, will be performed within two weeks of the patient's clinical evaluations by chest CT and x-ray. The study scan may be done within 2 weeks prior or two weeks following standard of care imaging. There cannot be any intervening therapies or procedures (i.e. biopsy or excision of lesions) done in between the standard of care (SOC) imaging and the s-DCT. All patients will have a breath held s-DCT scan in an anterior-posterior direction.

All patients will have a breath held s-DCT scan in an anterior-posterior direction

Scatter corrected s-DCT

Ertan Pamuklar, MD

This is a study that will evaluate the utility of a scatter reduction technique in reducing dose and increasing the sensitivity of stationary digital chest tomosynthesis (s-DCT) in the detection of lung lesions.

Digital tomosynthesis is an imaging modality that produces 3D sectional information using x-ray projections acquired over a limited scanning angle. Scatter is known to be the primary source of image degradation in x-ray based imaging.

The investigators have developed an approach that measures scatter through a low dose (3% of the conventional scan) scatter measurement technique. Preliminary studies have shown that scatter reduction in DCT can significantly improve quality. The approach will characterize the reader confidence in lung nodule detection in a scatter corrected chest tomosynthesis imaging approach as compared to the conventional chest tomosynthesis.

Fifty (50) patients who have undergone a clinical non-contrast CT with lung nodules will be asked to have an s-DCT (scan) within 4 weeks (+/- 2 week) of their clinical CT with no intervening procedures or therapies (i.e. biopsy of lung nodules). Investigators will then perform a reader study to evaluate the radiologist reader confidence in images generated from the scatter reduction technique versus more conventional chest tomosynthesis imaging.

Clinical Evaluation of Primary Sampling Scatter Correction for Chest Tomosynthesis

Deidentified individual data that supports the results will be shared beginning 9 to 36 months following publication provided the investigator who proposes to use the data has approval from an Institutional Review Board (IRB), Independent Ethics Committee (IEC), or Research Ethics Board (REB), as applicable, and executes a data use/sharing agreement with UNC.

Readers will rate their confidence in images from the experimental modality (sDCT with scatter correction) as compared to the conventional scan (chest CT with x-ray) on a 7 point Likert scale (-3 to 3) based on ability to identify lesion(s) present comparing each modality. A value of -3 is significantly less confident in the s-DCT representation 0 is the same confidence in modalities, and 3 is significantly more confident in the s-DCT representation compared to the conventional. Each individual will have a single value per reader. Two readers compared each scan. The overall reader preference between modalities was calculated by determining the mean value.

Sensitivity will be defined as the ability of s-DCT images to detect lesions positively identified on gold standard CT images.

National Cancer Institute (NCI)

UNC Lineberger Comprehensive Cancer Center

The study scan, s-DCT and correction scan, will be performed within two weeks of the patient's clinical evaluations by chest CT and x-ray. The study scan may be done within 2 weeks prior or two weeks following standard of care imaging. There cannot be any intervening therapies or procedures (i.e. biopsy or excision of lesions) done in between the standard of care (SOC) imaging and the s-DCT. All patients will have a breath held s-DCT scan in an anterior-posterior direction.

Scatter corrected s-DCT: All patients will have a breath held s-DCT scan in an anterior-posterior direction

Scatter Corrected s-DCT

Age, Continuous

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

United States

Region of Enrollment

Director, Clinical Research, Department of Radiology

Reader Confidence in s-DCT Images Compared to Conventional CT (Units on a Scale)

Sensitivity of s-DCT Images (Percentage of Positive Scans)

Overall Study

Neoplasm Metastasis

Neoplastic Processes

Analgesics

Central Nervous System Depressants

All Drugs and Chemicals

Narcotics

This is a survey study to evaluate the feasibility and effectiveness of an affordable, $400 flat rate, same-day consultation, simulation, and delivery of a single fraction of palliative radiation therapy for patients with symptomatic bony metastatic disease who are currently enrolled in hospice. Treatment planning and delivery of palliative radiotherapy will utilize "standard of care" techniques. A physician survey of feasibility will be conducted on the treatment day. Patient surveys will conducted on the day of treatment and at 2 weeks, 4 weeks, 2 months, 3 months, 4 months, 5 months, and 6 months after treatment.

Undergo standard of care radiation therapy

Radiation Therapy

The patient quality of life as measured by the ESAS-r; Edmonton Symptom Assessment System revised.

Quality-of-Life Assessment

The surveys consists of Radiation Therapy Worthfullness survey; BPI: brief pain inventory; NUS: narcotics usage survey.

Survey Administration

Drew Moghanaki, MD, MPH

This is a survey study to evaluate the feasibility and effectiveness of an affordable, $400 flat rate, same-day consultation, simulation, and delivery of a single fraction of palliative radiation therapy for patients with symptomatic bony metastatic disease who are currently enrolled in hospice. Treatment planning and delivery of palliative radiotherapy will utilize "standard of care" techniques.

Compassionate Same-Day Evaluation & Delivery of XRT for Bony Metastasis in Hospice Patients

Feasibility of a Compassionate Same-Day Evaluation and Delivery of Single Fraction Radiotherapy for Palliation of Symptomatic Bony Metastasis in Hospice Patients

Quantify the percentage of patients receiving the treatment who believe that the treatment was worthwhile

Patient evaluation will consist of surveys conducted at the time of treatment measured by the Radiation Oncologist Evaluation and Feasibility Assessments survey

Evaluate the treatment influence on the rate of pain stabilization and/or reduction as measured by the validated BPI patient questionnaire.

Evaluate the treatment influence on patient quality of life as measured by the ESAS.

Virginia Commonwealth University

As this is a survey study and not a drug study, changed from an "Adverse Events" section to a "Study Risks" section. No AEs or SAEs were collected.

Single fraction radiotherapy

Radiotherapy: Single fraction radiotherapy. All study participants will be evaluated, simulated, and treated with conventional single fraction palliative radiotherapy using standard techniques with CT-based treatment.

planning.

Radiotherapy

Age, Categorical

No data analysis or outcome measures for one participant enrolled and zero participants analyzed. Early suspension and termination due to slow accrual from Protocol Review and Monitoring Committee.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Phase I Study of iPS Cell Generation From Patients With COPD	NCT01860898	Thoracic Diseas... Respiratory Tra... Cancer of Lung Cancer of the L... Lung Cancer Lung Diseases, ... COPD Pulmonary Emphy... Neoplasms, Lung Neoplasms, Pulm... Pulmonary Cance... Pulmonary Neopl... Carcinoma, Non-... Carcinoma, Smal...	Skin Biopsy	18 Years -	Mayo Clinic
A Phase I Study of iPS Cell Generation From Patients With COPD	NCT01860898	Thoracic Diseas... Respiratory Tra... Cancer of Lung Cancer of the L... Lung Cancer Lung Diseases, ... COPD Pulmonary Emphy... Neoplasms, Lung Neoplasms, Pulm... Pulmonary Cance... Pulmonary Neopl... Carcinoma, Non-... Carcinoma, Smal...	Skin Biopsy	18 Years -	Mayo Clinic
Evaluation of Chronic Pain After Nerve Section During Thoracotomy	NCT00653367	Lung Cancer	Nerve section	18 Years - 75 Years	Rigshospitalet, Denmark
Clinical Evaluation of Primary Sampling Scatter Correction for Chest Tomosynthesis	NCT04076696	Pulmonary Nodul... Pulmonary Nodul...	Scatter correct...	18 Years -	UNC Lineberger Comprehensive Cancer Center
Compassionate Same-Day Evaluation & Delivery of XRT for Bony Metastasis in Hospice Patients	NCT01760941	Symptomatic Oss...	Radiation Thera... Quality-of-Life... Survey Administ...	18 Years -	Virginia Commonwealth University
Evaluation of Chronic Pain After Nerve Section During Thoracotomy	NCT00653367	Lung Cancer	Nerve section	18 Years - 75 Years	Rigshospitalet, Denmark

Spots Global Cancer Trial Database for chest

Every month we try and update this database with for chest cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for chest

Every month we try and update this database with for chest cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for chest cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.