Neoplasms

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Symptoms and General Pathology

Rare Diseases

Carcinoma

Carcinoma, Non-Small-Cell Lung

Lung Diseases, Obstructive

Carcinoma, Small Cell

Lung Neoplasms

Lung Diseases

Pulmonary Emphysema

Emphysema

Thoracic Diseases

Respiratory Tract Diseases

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Carcinoma, Bronchogenic

Bronchial Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Pulmonary Disease, Chronic Obstructive

Chronic Disease

Disease Attributes

Chronic Graft Versus Host Disease

Biopsy samples will be taken as a 2mm x 2cm excision of a wedge of skin at the edge of the incision during your surgery at the Mayo Clinic Rochester. Such excisions are frequently done as part of routine skin closure for optimal skin cosmesis following the surgical procedure.

Skin Biopsy

Dennis A Wigle, MD, PhD

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, the investigators will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells.

A Phase I Study of iPS Cell Generation From Patients With COPD

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, we will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells. Markers of induced pluripotent phenotype will be utilized to assess successful reprogramming.

Mayo Clinic

M.D., P.h.D.

Multiple Pulmonary Nodules

Patients undergoing thoracic normal dose-CT with undergo an additional Ultralow-Dose-CT

Ultralow-Dose-CT

Michael A Messerli, MD

To investigate the diagnostic value of ultralow-dose computed tomography in the detection of pulmonary nodules and lung parenchym alterations (e.g. emphysema) compared to standard-dose-CT.

Diagnostic Value of Ultralow-dose Computed Tomography for the Detection of Pulmonary Nodules and Lung Parenchym Alterations Compared to Standard-dose CT

Difference in nodule detectability in Ultralow-Dose-CT compared to Standard-Dose-CT measured using McNemar test

Cantonal Hospital of St. Gallen

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Phase I Study of iPS Cell Generation From Patients With COPD	NCT01860898	Thoracic Diseas... Respiratory Tra... Cancer of Lung Cancer of the L... Lung Cancer Lung Diseases, ... COPD Pulmonary Emphy... Neoplasms, Lung Neoplasms, Pulm... Pulmonary Cance... Pulmonary Neopl... Carcinoma, Non-... Carcinoma, Smal...	Skin Biopsy	18 Years -	Mayo Clinic
A Phase I Study of iPS Cell Generation From Patients With COPD	NCT01860898	Thoracic Diseas... Respiratory Tra... Cancer of Lung Cancer of the L... Lung Cancer Lung Diseases, ... COPD Pulmonary Emphy... Neoplasms, Lung Neoplasms, Pulm... Pulmonary Cance... Pulmonary Neopl... Carcinoma, Non-... Carcinoma, Smal...	Skin Biopsy	18 Years -	Mayo Clinic
Diagnostic Value of Ultralow-dose Computed Tomography for the Detection of Pulmonary Nodules and Lung Parenchym Alterations Compared to Standard-dose CT	NCT02468609	Multiple Pulmon... Pulmonary Emphy...	Ultralow-Dose-C...	18 Years - 90 Years	Cantonal Hospital of St. Gallen

Spots Global Cancer Trial Database for pulmonary emphysema