Parent and child participants complete the COG Standard Neuropsychological and Behavioral Battery at approximately 9, 30, and 60 months post-diagnosis in a 1-2 hour testing session conducted by a neuropsychologist or psychologist. The Battery consists of measures of intelligence, processing speed, attention, memory, language preference, behavioral/social/emotional function, executive function, adaptive function, and quality of life.

Complete COG Standard Neuropsychological and Behavioral Battery

Cognitive Assessment

Quality-of-Life Assessment

Site Public Contact

Matthew A. Kutny

Santosh S. Hanmod

Jessica Boklan

Robert M. Cooper

Jacqueline N. Casillas

Leo Mascarenhas

Fataneh (Fae) Majlessipour

William A. May

Vonda L. Crouse

Carla B. Golden

Laura A. Campbell

Elyssa M. Rubin

Jay Michael S. Balagtas

William D. Roberts

Anuradha Banerjee

Nicholas K. Foreman

Michael S. Isakoff

Nina S. Kadan-Lottick

Ramamoorthy Nagasubramanian

Jeffrey A. Toretsky

Jeffrey S. Dome

Emad K. Salman

Iftikhar Hanif

Julio C. Barredo

Enrique A. Escalon

Fouad M. Hajjar

Amy A. Smith

Stacie L. Stapleton

Dana A. Obzut

Narayana Gowda

Anna J. Janss

Andrew L. Pendleton

Wade T. Kyono

Eugenia Chang

Stewart Goldman

Mary L. Schmidt

Tara O. Henderson

Eugene Suh

Rebecca E. McFall

Jaime M. Libes

Sandeep Batra

Samantha L. Mallory

Mariko Sato

James T. Badgett

Ashok B. Raj

Lolie C. Yu

Teresa A. York

Kenneth J. Cohen

Jason Law

Nicole J. Ullrich

Patricia L. Robertson

Jeffrey W. Taub

Adonis N. Lorenzana

Renuka Gera

Jessica M. Foley

Katharina E. Elliott

Michael K. Richards

Christopher L. Moertel

Carola A. Arndt

Betty L. Herrington

Keith J. August

Joshua B. Rubin

Robin D. Hanson

Don W. Coulter

Alan K. Ikeda

Julie Kim

Burton E. Appel

John J. Gregory

Richard A. Drachtman

Teena Bhatla

Alissa Kahn

John F. Kuttesch

Lauren R. Weintraub

Lisa Gennarini

Denise A. Rokitka

Mark P. Atlas

Leanne M Embry

This research trial studies neuropsychological (learning, remembering or thinking) and behavioral outcomes in children and adolescents with cancer by collecting information over time from a series of tests.

PRIMARY OBJECTIVES:

I. To institute procedures to ensure a consistent, streamlined, and efficient administration of the neuropsychological/behavioral tests in a cooperative group setting in order to maximize compliance with a standardized assessment battery conducted at 3 standardized time points.

OUTLINE:

Parent and child participants complete the COG Standard Neuropsychological and Behavioral Battery at approximately 9, 30, and 60 months post-diagnosis in a 1-2 hour testing session conducted by a neuropsychologist or psychologist. The Battery consists of measures of intelligence, processing speed, attention, memory, language preference, behavioral/social/emotional function, executive function, adaptive function, and quality of life.

Neuropsychological and Behavioral Testing in Younger Patients With Cancer

Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children With Cancer

National Cancer Institute (NCI)

Children's Oncology Group

DNA from peripheral blood or saliva sample of patients is analyzed for the presence of polymorphisms in genes associated with an increased risk of late-occurring complications.

Laboratory Biomarker Analysis

Questionnaire Administration

Smita Bhatia

David L. Becton

Saro H. Armenian

Doured Daghistani

Lillian R. Meacham

Colleen H. McDonough

Bassem I. Razzouk

Vlad C. Radulescu

Nadine P. SantaCruz

Rama Jasty

Kathleen J. Yost

Joseph P. Neglia

Gail C. Megason

Robert J. Hayashi

Michael B. Harris

Nibal A. Zaghloul

Mark E. Weinblatt

Danielle N. Friedman

Philip M. Monteleone

Lars M. Wagner

Thomas W. McLean

Samuel O. Anim

Rajaram Nagarajan

Mark A. Ranalli

Ayman A. El-Sheikh

Rene Y. McNall-Knapp

Janice F. Olson

Felipe S. Bautista-Otanez

This clinical trial studies cancer survivors to identify those who are at increased risk of developing late-occurring complications after undergoing treatment for childhood cancer. A patient's genes may affect the risk of developing complications, such as congestive heart failure, avascular necrosis, stroke, and second cancer, years after undergoing cancer treatment. Genetic studies may help doctors identify survivors of childhood cancer who are more likely to develop late complications.

PRIMARY OBJECTIVES:

I. To identify key adverse events developing in patients (cases) with a primary cancer diagnosed at age 21 or younger.

II. To characterize the key adverse events with respect to the nature of the primary malignancy (pathology, stage) and coded details of the therapeutic protocol.

III. To identify treatment-related and demographic risk factors through a direct comparison of the case-group and controls identified from the remaining patients with the same primary diagnosis.

IV. To compare the frequency of mutations or polymorphisms in specific candidate genes in cases and controls, using constitutional deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) from the cases and controls.

V. To explore the role and nature of gene-environment interaction in the development of key adverse events.

OUTLINE:

DNA and RNA from peripheral blood or saliva sample of patients is analyzed for the presence of polymorphisms in genes associated with an increased risk of late-occurring complications.

Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors

Key Adverse Events After Childhood Cancer

Epidemiological, clinical and laboratory variables will be tested for their association with key adverse events. McNemar's test for paired data will be used to compare the unmatched general characteristics of cases and controls.

Allele frequencies will be estimated by the gene counting method, and the chi-square test will be used to check for departures from Hardy-Weinberg equilibrium.

The crude disease-exposure association will be determined by estimating the OR and its 95% confidence interval (CI). This will be done by univariate conditional logistic regression, to account for the matched design. The significance of the OR will be assessed by the Wald test. Backward stepwise regression procedures will be used to develop the final multivariate model and possible interactions will be examined. The fit of the model will be assessed by the logistic regression diagnostics procedure.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Neuropsychological and Behavioral Testing in Younger Patients With Cancer	NCT00772200	Childhood Malig...	Cognitive Asses... Quality-of-Life...	1 Month -	Children's Oncology Group
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors	NCT00082745	Childhood Malig...	Laboratory Biom... Questionnaire A...	- 99 Years	Children's Oncology Group

Spots Global Cancer Trial Database for childhood malignant neoplasm