Neoplasms

Blood and Lymph Conditions

All Conditions

Immune System Diseases

Symptoms and General Pathology

Rare Diseases

Leukemia

Leukemia, Lymphoid

Leukemia, Lymphocytic, Chronic, B-Cell

Neoplasms by Histologic Type

Hematologic Diseases

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Leukemia, B-Cell

Chronic Disease

Disease Attributes

Chronic Graft Versus Host Disease

Chronic Lymphocytic Leukemia

Micronutrients

All Drugs and Chemicals

Selenium

Low Dose Selenious Yeast Tablets

High Dose Selenious Yeast Tablets

Zheng Wei, M.D.

Yi-an Zhang, M.D.

Shi-yang Gu, M.D.

The purpose of this study is to evaluate the safety and effectiveness of Selenious Yeast Tablets in Chronic Lymphocytic Leukemia Patients without Indication of Chemotherapy

A large portion of CLL patients has no indications of chemotherapy when diagnosed. In patients with CLL, the mean serum selenium levels are lower than normal. There is a correlation between the selenium level and the clinical stage. We discovered that sodium selenite inhibited the expression of CXCL-1 and restored the defective necroptotic pathway of CLL cells together with TNF-α and z-VAD in vitro. The purpose of this study is to evaluate the safety and effectiveness of Selenious Yeast Tablets in preventing CLL patients without indication of chemotherapy from disease development.

Selenious Yeast in CLL Patients w/o Indication of Chemotherapy

Administration of Selenious Yeast Tablets in Chronic Lymphocytic Leukemia Patients Without Indication of Chemotherapy: A Multicenter Study

Decrease rate of peripheral lymphocyte counts

safety profile of the subjects from enrollment

Shanghai Changzheng Hospital

Shanghai Zhongshan Hospital

Fortunato Morabito, MD

Emanuela A Pesce, BSc

Massimo Federico, MD

Manlio Ferrarini, MD

The purpose of the present study is to develop a biological prognostic index in patients with Binet stage A Chronic Lymphocytic Leukemia (CLL) who do not necessitate therapy according to NCI guidelines and to prospectively validate the proposed score system based on the absence/presence of 1, 2 or 3 unfavorable prognostic markers such as cluster of differentiation 38 (CD38) expression, Zap-70 expression and immunoglobulin heavy chain variable region (IgVH) configuration.

Clinical data including information on disease localization and laboratory parameters will be collected at study entry, during follow up and at disease progression (or after 36 months after registration) Biological markers will be evaluated at centralized laboratory, at study entry and at time of disease progression (or after 24 months of follow-up for non progressed patients) Using the scoring system, patients can be separated into 3 risk groups: low-risk (score 0), intermediate-risk (score 1) and high-risk (score 2-3), with significantly different clinical courses.

Prospective Collection of Biological Data of Prognostic Relevance in Patients With B-Cell Chronic Lymphocytic Leukemia

Prospective Collection of Biological Data of Prognostic Relevance in Patients

Gruppo Italiano Studio Linfomi

Subjects will be instructed to adopt a whole-food, plant-based diet for 8 weeks. They will attend weekly group cooking classes led by a RD and receive weekly health coaching sessions.

Whole-food, plant-based diet

Ariel Portera, DO

This study will evaluate the feasibility of an 8-week vegan whole-food, plant-based dietary intervention in subjects with low risk CLL who are undergoing observation. Over the course of 8 weeks, participants will attend weekly group cooking classes via Zoom lead by a RD. Participants will also attend weekly individual meetings with a health coaches to assist with adherence to the dietary intervention.

Feasibility of a Whole-Food, Plant-Based Diet for Patients With Low-Risk Chronic Lymphocytic Leukemia (CLL)

Feasibility of a Whole-Food, Plant-Based Dietary Intervention for Patients With Low-Risk Chronic Lymphocytic Leukemia

Adherence to the dietary intervention will be calculated using a dietary index developed specifically for this diet. Dietary adherence scores will be calculated using a pre- and post-intervention food frequency questionnaire, as well as 3-day food diaries obtained throughout the intervention.

Subject satisfaction will be assessed post-intervention using an acceptability, appropriateness and feasibility questionnaire. The questionnaire does not use a scoring system, rather statements will be provided and participants will provide an answer ranging from "completely disagree" to "completely agree."

Cooking class attendance will also be used as a measure of adherence.

Recruitment rate will be assessed by examining the number of potentially eligible participants, number contacted, consent rates, number completing the intervention.

Retention will be calculated using the number of participants who enroll in the study and the number of participants who complete the 8 week intervention.

Will be measured using standard methods. Weight and height will be combined to report BMI in kg/m\^2.

Will be measured using standard methods, both systolic and diastolic blood pressure will be assessed.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Selenious Yeast in CLL Patients w/o Indication of Chemotherapy	NCT05136378	Chronic Lymphoc... Chronic Lymphoc... Chronic Lymphoc... Chronic Lymphoc...	Low Dose Seleni... High Dose Selen...	17 Years - 99 Years	Shanghai Zhongshan Hospital
Prospective Collection of Biological Data of Prognostic Relevance in Patients With B-Cell Chronic Lymphocytic Leukemia	NCT00917540	Chronic Lymphoc... Chronic Lymphoc... Chronic Lymphoc...		18 Years - 80 Years	Gruppo Italiano Studio Linfomi
Prospective Collection of Biological Data of Prognostic Relevance in Patients With B-Cell Chronic Lymphocytic Leukemia	NCT00917540	Chronic Lymphoc... Chronic Lymphoc... Chronic Lymphoc...		18 Years - 80 Years	Gruppo Italiano Studio Linfomi
Feasibility of a Whole-Food, Plant-Based Diet for Patients With Low-Risk Chronic Lymphocytic Leukemia (CLL)	NCT06377501	Chronic Lymphoc...	Whole-food, pla...	18 Years -	University of California, San Diego
Feasibility of a Whole-Food, Plant-Based Diet for Patients With Low-Risk Chronic Lymphocytic Leukemia (CLL)	NCT06377501	Chronic Lymphoc...	Whole-food, pla...	18 Years -	University of California, San Diego
Feasibility of a Whole-Food, Plant-Based Diet for Patients With Low-Risk Chronic Lymphocytic Leukemia (CLL)	NCT06377501	Chronic Lymphoc...	Whole-food, pla...	18 Years -	University of California, San Diego

Spots Global Cancer Trial Database for chronic lymphocytic leukemia stage a(0)