Neoplasms

Digestive System Diseases

All Conditions

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Central Nervous System Depressants

All Drugs and Chemicals

Hematinics

Anesthetics

Propofol

Liver Extracts

Hypnotics and Sedatives

Anesthetics, Intravenous

Anesthetics, General

Use propofol for sedation during anesthesia.

Use ciprofol for sedation during anesthesia

Propofol was IV infused 1.0-1.5mg/Kg and then maintenance at 1.0-2.0mg/Kg/h

Ciprofol was IV infused 0.2- 0.3mg/Kg and then maintenance at 0.2-0.3mg/Kg/h

Ciprofol

Xiaochun Jin, MD.

Xiaochun Jin, M.D.

Jiangling Wang, Ph.D

Jiangling Wang, Dr.

Efficacy and Safety of Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation

Ciprofol was injected before ablation and sedation scores were measured to make sure certain sedation.

Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation

Efficacy and Safety of Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation: A Double-Blind, Randomized, Noninferiority Trial

Satisfaction assessed by MOAAS, Modified Observer's Assessment of Alertness and Sedation (MOAA/S) scale is a validated 6-point scale assessing responsiveness of patients coinciding with the American Society of Anesthesiologists (ASA) continuum of sedation. MOAA/S 0 to 1 represent deeper sedation, MOAA/S 2 to 3 represent moderate sedation and MOAA/S 4 to 5 represent lighter to no sedation. In this study, MOAAS between 2-3 after initial IV dosage of propofol/ciprofol was defined as efficacy sedation.

Any respiratory depression from the injection of propofol/ciprofol to fully recovery after surgery. Respiratory depression was defined as respiratory rate less than 10 times/min or the oxygen saturation decrease more than 5% compared with the baseline value.

Pain during injection of propofol/ciprofol

Zhejiang Cancer Hospital

Principle Investigator

Nutritional and Metabolic Diseases

Symptoms and General Pathology

Rare Diseases

Stomach Neoplasms

Overweight

Obesity

Hypoxia

Ulcer

Polyps

Stomach Ulcer

Overnutrition

Nutrition Disorders

Body Weight

Stomach Diseases

Signs and Symptoms, Respiratory

Peptic Ulcer

Duodenal Diseases

Intestinal Diseases

Stomach Cancer

Anesthesia induction:Propofol 1.5mg/kg Anesthesia maintenance: Propofol 0.75mg/kg

Anesthesia induction:ciprofol 0.4mg/kg Anesthesia maintenance: ciprofol 0.2mg/kg

The sedation of gastrointestinal endoscopy with Ciprofol

The sedation of gastrointestinal endoscopy with Propofol

weifeng Yu, PhD

diansan Su, PhD

Zhen Hua

Yanhong Lian

Hui Wang

Diansan Su

Linzhong Zhang

Ciprofol is a new general anesthetic, which combine with γ- Aminobutyric acid-a (GABAA) receptor. Ciprofol has shown equivalent anesthetic efficacy of propofol at 1/4 to 1/5 of the dosage. Ciprofol has the pharmacodynamic characteristics of rapid onset, stable and rapid recovery. Phase III clinical results showed that the incidence of injection pain and respiratory and circulatory depression of ciprofol was lower than that of propofol. Therefore, ciprofol has a good application prospect in the sedation for gastrointestinal endoscopy, especially for overweight and obese patients. We conduct a Multicenter, Randomized, Open-label, Propofol-controlled Study to Evaluate the incidence of hypoxia and severe hypoxia during Gastroenterological Endoscope sedated with CiProfol in Overweight or Obesity patients.

Multicenter, Randomized, Open-label, Propofol-controlled

Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients

The Incidences Of Hypoxia And Severe Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol Compared With Propofol In Overweight Or Obesity Adults Patients, A Multicenter, Randomized, Controlled Trial

hypoxia( 75%≤SpO2≤89% for\<60s);severe hypoxia(SpO2\<75%，or SpO2\<90% for \>60s)

severe hypoxemia(SpO2\<75%，or SpO2\<90% for \>60s)

subclinical respiratory depression（90% ≤SpO2 ≤95% ）

Patients complain pain at the site of injection or tell investigators feeling pain when they were asked before they lose consciousness.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation	NCT06178926	Liver Cancer Ciprofol	Propofol Ciprofol	18 Years - 75 Years	Zhejiang Cancer Hospital
Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation	NCT06178926	Liver Cancer Ciprofol	Propofol Ciprofol	18 Years - 75 Years	Zhejiang Cancer Hospital
Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients	NCT05518929	Gastric Ulcer Gastric Cancer Gastrointestina...	Ciprofol Propofol	18 Years - 80 Years	RenJi Hospital
Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients	NCT05518929	Gastric Ulcer Gastric Cancer Gastrointestina...	Ciprofol Propofol	18 Years - 80 Years	RenJi Hospital

Spots Global Cancer Trial Database for ciprofol

Every month we try and update this database with for ciprofol cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for ciprofol

Every month we try and update this database with for ciprofol cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for ciprofol cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.