Neoplasms

All Conditions

Digestive System Diseases

Ear, Nose, and Throat Diseases

Rare Diseases

Carcinoma

Carcinoma, Squamous Cell

Esophageal Achalasia

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Esophageal Motility Disorders

Esophageal Spasm, Diffuse

Deglutition Disorders

Esophageal Diseases

Gastrointestinal Diseases

Neoplasms, Squamous Cell

Idiopathic Achalasia

Cardiospasm

Achalasia patients were periodically submitted to clinical assessment, barium swallow (esophageal diameter and residual barium column were measured), endoscopy. Mucosal esophageal biopsies were taken in order to diagnose dysplasia or epidermoid carcinoma.

Clinical instrumental examinations

Sandro Mattioli, MD

Marisaluisa Lugaresi, MD

Marialuisa Lugaresi, MD

Valentina Tassi, MD

Niccolò Daddi, MD

Benedetta Mattioli, MD

Francesca Fortunato, PhD

Rocco Maurizio Zagari, MD

Francesco Bassi, MD

Vladimiro Pilotti, MD

Esophageal achalasia is a precancerous condition for epidermoid carcinoma; incidence and risk factors for cancer development are not defined. Incidence and risk factors for epidermoid carcinoma development in achalasia patients were investigated.

In order to define incidence and risk factors for epidermoid carcinoma 681 patients affected by esophageal achalasia observed since 1973 were followed up with no time limits according to a prospective follow-up protocol. The local institutional review board approved using the database from the division of thoracic surgery for research purposes. Clinical, radiological and endoscopic data of achalasia patients were collected and analyzed.

Epidermoid Cancer Development in Esophageal Achalasia

Incidence and Risk Factors for Development of Epidermoid Carcinoma in Esophageal Achalasia

Detection of epidermoid carcinoma of the esophagus by means of upper GI endoscopy

Result of achalasia treatment assessed by means of semiquantitative grading scales of dysphagia and gastro-esophageal reflux

Sandro Mattioli

Prof. Sandro Mattioli

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Epidermoid Cancer Development in Esophageal Achalasia	NCT03546998	Achalasia Epidermoid Carc...	Clinical instru...	-	University of Bologna
Epidermoid Cancer Development in Esophageal Achalasia	NCT03546998	Achalasia Epidermoid Carc...	Clinical instru...	-	University of Bologna

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