Neoplasms

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Adenoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

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Cola

During the insertion phase of the first-pass colonoscopy, water exchange (WE) method was used. WE entailed the infusion of water to open the lumen and sequentially suction of water. When the cecum was reached and after most of the water was suctioned to collapse the cecal lumen, CO2 was opened during the withdrawal phase of the first-pass colonoscopy. After the first complete withdrawal of the colonoscope, a second colonoscopic examination aided by CO2 insufflation during insertion and withdrawal was performed by the same endoscopist. The colonoscope was reinserted into the cecum as quickly as possible, and the entire colon was re-examined. Polyp resection was carried out during insertion and withdrawal of the first- and second-pass examinations.

During the first-pass colonoscopy, the procedure was performed in the usual fashion, with minimal CO2 insufflation to aid insertion. Cleaning of colon was predominantly performed during withdrawal. After the first complete withdrawal of the colonoscope, a second colonoscopic examination aided by CO2 insufflation during insertion and withdrawal was performed by the same endoscopist. The colonoscope was reinserted into the cecum as quickly as possible, and the entire colon was re-examined. Polyp resection was carried out during insertion and withdrawal of the first- and second-pass examinations.

During back-to-back colonoscopy, the first examination was completed with water exchange during insertion and CO2 insufflation during withdrawal. The second examination was completed with CO2 insufflation during both the insertion and withdrawal.

Water exchange colonoscopy

During back-to-back colonoscopy, the first examination was completed with CO2 insufflation during both the insertion and withdrawal. The second examination was also completed with CO2 insufflation during both the insertion and withdrawal.

CO2 insufflation colonoscopy

Chi-Liang Cheng

This was an observational study comparing consecutive group of WE and CO2 insufflation in terms of right and proximal colon AMR by tandem colonoscopy.

This was a prospective observational study to assess how WE colonoscopy would fit into clinical and research practices. We first observed whether optimal WE colonoscopy decreased the AMR in the right and proximal colon in a tandem approach. If WE did lower the AMR as compared with data in the literature, a randomized RCT deserves to be studied. For the calculation of sample size in the upcoming RCT, the AMR in the CO2 group would be collected. The differences of the AMRs in the right and proximal colon determined by tandem colonoscopy using WE or CO2 insufflation would then be compared.

Adenoma Miss Rate With Water Exchange vs Carbon Dioxide Colonoscopy

Water Exchange Colonoscopy Decreased Adenoma Miss Rates in the Right and Proximal Colon: An Observational Study Using A Tandem Colonoscopy Approach

Right-colon (cecum, A-colon, hepatic flexure) adenomas detected on the second-pass examination were used for the calculation of adenoma miss. Adenoma miss rate was calculated as the number of adenomas missed in the first colonoscopy divided by the total number of adenomas detected during both the first and second colonoscopies.

Proximal-colon (cecum, A-colon, hepatic flexure, T-colon) adenomas detected on the second-pass examination were used for the calculation of adenoma miss. Adenoma miss rate was calculated as the number of adenomas missed in the first colonoscopy divided by the total number of adenomas detected during both the first and second colonoscopies.

Evergreen General Hospital, Taiwan

M.D.

Water Exchange Colonoscopy

CO2 Insufflation Colonoscopy

During the insertion phase of the first-pass colonoscopy, WE method was used. When the cecum was reached, CO2 was opened during the withdrawal phase of the first-pass colonoscopy. After the first complete withdrawal of the colonoscope, a second colonoscopic examination aided by CO2 insufflation during insertion and withdrawal was performed by the same endoscopist. The colonoscope was reinserted into the cecum as quickly as possible, and the entire colon was re-examined. Polyp resection was carried out during insertion and withdrawal of the first- and second-pass examinations.

Total

Age, Continuous

Sex: Female, Male

Race and Ethnicity were not collected from any participant.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Adenoma Miss Rate With Water Exchange vs Carbon Dioxide Colonoscopy	NCT03832322	Colonic Adenoma Water Exchange ...	Water exchange ... CO2 insufflatio...	20 Years - 75 Years	Evergreen General Hospital, Taiwan
Adenoma Miss Rate With Water Exchange vs Carbon Dioxide Colonoscopy	NCT03832322	Colonic Adenoma Water Exchange ...	Water exchange ... CO2 insufflatio...	20 Years - 75 Years	Evergreen General Hospital, Taiwan
Adenoma Miss Rate With Water Exchange vs Carbon Dioxide Colonoscopy	NCT03832322	Colonic Adenoma Water Exchange ...	Water exchange ... CO2 insufflatio...	20 Years - 75 Years	Evergreen General Hospital, Taiwan

Spots Global Cancer Trial Database for co2 insufflation colonoscopy