Nervous System Diseases

All Conditions

Epilepsy

Brain Diseases

Central Nervous System Diseases

tumor patients without epileptic seizures

patients perform simple tasks like watching a video or memorizing items

cognitive testing

Johannes Sarnthein, Prof Dr

The investigators want to characterize high-frequency oscillations (HFOs) in intracranial recordings, which may occur as markers of epileptogenic tissue and also under physiological stimulation.

The investigators want to show that recording of high-frequency oscillations (HFOs) is feasible in our project population both intraoperatively and during presurgical physiological conditions.

Recording High Frequency Oscillations in Patients With Tumors and Epilepsy

Recording High Frequency Oscillations in Patients With Tumors and Epilepsy.

University of Zurich

Neoplasms

Brain Neoplasms

Central Nervous System Neoplasms

Nervous System Neoplasms

Patients receiving radiotherapy after surgery for brain tumor

Patients NOT receiving radiotherapy after surgery for brain tumor

Patients will have their cognitive function tested by the use of standardized cognitive test and fill in questionnaires.

Cognitive function will be assessed by standardized cognitive tests: Hopkins verbal learning test (HVLT), Trail Making Test part A and B (TMT A and TMT B), Pased Auditory Test (PASAT), Wechsler Adult Intelligence Scale coding and digit span (WAIS-IV), Controlled Oral Word Association Test (Cowat) and STROOP colour and word test (STROOP)

Questionnaire include; Quality of life; EORTC QlQ-C30 (QlQ-C30), FACIT-Fatigue Scale (Version 4) (FACIT), Pittsburg Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), Patient's Assessment of Own Functioning Inventory (PAOFI).

Cognitive testing

Morten Høyer, M.D.

This study will assess cognitive function in adult patients with a primary brain tumour treated with surgical resection with or without radiation therapy (RT). All types of brain tumours apart from glioblastoma will be included

RT to brain tumours causes cognitive dysfunction. The extent of RT induced changes in cognitive function and radio-sensitivity of the brain is unknown. RT with protons instead of photons spares the healthy brain tissue more and is believed to reduce the risk of cognitive dysfunction. There is modest knowledge on which parts of the brain the investigators need to spare, to prevent cognitive dysfunction.

The study is a cross sectional study assessing cognitive function in patients with brain tumours previously treated with RT compared to a similar non irradiated group. 104 patients with specified brain tumours from Aarhus University Hospital treated in the period 2006-2016 will be included. The patients will do patient reported outcome (PRO) and undergo neuropsychological assessment with standardized tests: They will do this prior to RT treatment and ½, 1, 3 and 5 years afterwards. The PRO's included measures on quality of life, fatigue, sleep, depression, anxiety, and socio demografica. The standardized tests are: Trail making Test (TMT); Hopkins Verbal Learning Test (HVLT); Controlled Oral Word Association Test (COWAT) - Animals and S; Coding and Digit Span from WAIS-IV; Paced Auditory Serial Addition Test (PASAT). The correlation between cognitive scores and RT dose-volume parameters to specific areas in the brain will be tested.

Cognitive Function After Radiation Therapy for Brain Tumours

To examine the correlation between memory impairment (assessed by HVLT-r) and mean dose to the hippocampus.

Examine correlations cognitive decline and subvolumes of the brain. Cognitive function will be assessed by standardized cognitive tests: Hopkins verbal learning test (HVLT), Trail Making Test part A and B (TMT A and TMT B), Pased Auditory Test (PASAT), Wechsler Adult Intelligence Scale coding and digit span (WAIS-IV), Controlled Oral Word Association Test (Cowat) and STROOP colour and word test (STROOP). Measures on cognitive test is time in seconds or number of "corrects".

Assessed by questionnaire; EORTC QlQ-C30 in order to examine the level of quality of life in brain tumour patients who has received radiation therapy

Assessed by questionnaire: FACIT-Fatigue scale (version 4) in order to explore the level of fatigue in brain tumour patients who has received radiation therapy

Assessed by questionnaire:Pittsburg Sleep Quality INDEX, PSQI in order to explore the level of quality of sleep in brain tumour patients who has received radiation therapy

Assessed by questionnaire: Hospital anxiety and depression Scale (HADS) in order to explore level of depression and anxiety in patients treated with radiation therapy for their brain tumour

Assessed by questionnaire; Patient's Assessment of Own Functioning Inventory (PAOFI), in order to assess patients own perception of cognitive function

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Recording High Frequency Oscillations in Patients With Tumors and Epilepsy	NCT02320136	Epilepsy Tumor	cognitive testi...	18 Years - 99 Years	University of Zurich
Cognitive Function After Radiation Therapy for Brain Tumours	NCT04118426	Primary Brain T... Radiation Toxic...	Cognitive testi...	18 Years - 100 Years	University of Aarhus
Recording High Frequency Oscillations in Patients With Tumors and Epilepsy	NCT02320136	Epilepsy Tumor	cognitive testi...	18 Years - 99 Years	University of Zurich

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