Neoplasms

Digestive System Diseases

All Conditions

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Herbal and Botanical

All Drugs and Chemicals

Cola

Participants in this arm will receive a letter from their provider informing them they are overdue for colon cancer screening and requesting their participation in colonoscopy, and including a referral for the procedure at a local endoscopy center. Participants will be provided a phone number if interested in navigated colonoscopy scheduling.

Participants in this arm will receive a letter from their provider informing them they are overdue for colon cancer screening and requesting their participation in their choice of either colonoscopy or mailed fecal immunochemical testing (FIT). The letter will include both a referral for the colonoscopy at a local endoscopy enter and a FIT kit with a lab requisition and instructions for completion.

Participants in this arm will receive a letter from their provider informing them they are overdue for colon cancer screening and requesting their participation in FIT testing. The letter will include a FIT kit with lab requisition and instructions for completion.

Mailed letter asking participants to complete CRC screening by colonoscopy

Colonoscopy Only

Mailed letter and FIT test asking participants to complete CRC screening by their choice of either colonoscopy or mailed FIT

Choice

Mailed letter and FIT test asking participants to complete CRC screening by mailed FIT

FIT Only

Shivan Mehta, MD

This is a 3-arm randomized trial aimed at increasing rates of participation in colorectal cancer (CRC) screening by outreach to patients' homes using choice architecture informed by behavioral science principles.

The investigators will evaluate the effectiveness of mailed outreach with choice between colonoscopy and FIT, and FIT alone, as compared to colonoscopy alone in increasing CRC screening rates.

Choice Architecture and Mailed Colorectal Cancer Screening Outreach in a Community Health Setting

Screening completion rate in arm 2 (Choice) to arm 1 (Colonoscopy only) and arm 3 (FIT only) separately.

The proportion of patients choosing either FIT or Colonoscopy in study arm 2 (Choice)

National Comprehensive Cancer Network

Abramson Cancer Center at Penn Medicine

Principal Investigator

Colonic Neoplasms

Colonoscopy outreach + mailed FIT follow-up

Colonoscopy + mailed FIT outreach and follow-up

Subjects will receive a mailed communication describing the importance of colorectal cancer screening with the option to schedule a colonoscopy through a VIP direct scheduling phone line. Subjects not scheduled after 4 weeks will receive a reminder letter to schedule colonoscopy.

Colonoscopy only

Subjects will receive a mailed communication describing the importance of colorectal cancer screening with the option to schedule a colonoscopy through a VIP direct scheduling phone line. Subjects not scheduled after 4 weeks will receive a reminder letter to either schedule colonoscopy or to complete the enclosed mailed FIT kit.

Subjects will receive a mailed communication describing the importance of colorectal cancer screening with the option to schedule a colonoscopy through a VIP direct scheduling phone line OR complete the enclosed mailed FIT kit. Subjects who have not completed FIT or scheduled colonoscopy within 4 weeks will be receive a reminder letter to either schedule colonoscopy or complete the mailed FIT kit previously sent.

Colonoscopy + Mailed FIT outreach and follow-up

Chyke Doubeni, MD

This pilot study is a 3-arm randomized control trial assessing the effectiveness of sequential or active choice in CRC (colorectal cancer) screening outreach vs. colonoscopy outreach only, in patients between 50-74 years old, who have received care at the University City or Valley Forge CCA (Community Care Associates) practices, are due for screening, and are asymptomatic for CRC. The three arms are: Arm 1: Direct schedule colonoscopy (Control), Arm 2: Direct schedule colonoscopy followed by mailed FIT(Fecal Immunochemical Test) (Sequential Choice), and Arm 3: Choice of direct schedule colonoscopy or mailed FIT (Active Choice).

This pilot study is a 3-arm randomized control trial assessing the effectiveness of sequential or active choice in CRC screening outreach vs. colonoscopy outreach only. The investigators will randomize participants to one of three study arms:

Arm 1: Direct schedule colonoscopy (Control) Arm 2: Direct schedule colonoscopy followed by mailed FIT (Sequential Choice) Arm 3: Choice of direct schedule colonoscopy or mailed FIT (Active Choice).

Choice Architecture and Colorectal Cancer Screening Outreach

Choice Architecture and Mailed Outreach for Colorectal Cancer Screening

The percentage of participants who successfully complete FIT or colonoscopy

The percentage of participants who choose either screening method (FIT vs. colonoscopy)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Choice Architecture and Mailed Colorectal Cancer Screening Outreach in a Community Health Setting	NCT04711473	Colorectal Canc...	Colonoscopy Onl... Choice FIT Only	50 Years - 74 Years	Abramson Cancer Center at Penn Medicine
Choice Architecture and Mailed Colorectal Cancer Screening Outreach in a Community Health Setting	NCT04711473	Colorectal Canc...	Colonoscopy Onl... Choice FIT Only	50 Years - 74 Years	Abramson Cancer Center at Penn Medicine
Choice Architecture and Colorectal Cancer Screening Outreach	NCT03246438	Cancer of Colon	Colonoscopy onl... Colonoscopy out... Colonoscopy + M...	50 Years - 74 Years	University of Pennsylvania
Choice Architecture and Colorectal Cancer Screening Outreach	NCT03246438	Cancer of Colon	Colonoscopy onl... Colonoscopy out... Colonoscopy + M...	50 Years - 74 Years	University of Pennsylvania
Choice Architecture and Colorectal Cancer Screening Outreach	NCT03246438	Cancer of Colon	Colonoscopy onl... Colonoscopy out... Colonoscopy + M...	50 Years - 74 Years	University of Pennsylvania

Spots Global Cancer Trial Database for colonoscopy only