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Docetaxel

Cisplatin

concurrent chemoradiation:CT:DDP 25mg/m2 D1+docetaxel 25mg/m2 D1,Weekly for 5 wks;RT：60Gy/30F/6W(3D-CRT or IMRT).Then,2 cycles consolidation chemotherapy were used:DDP 75mg/m2 D1+docetaxel 75mg/m2 D1, Q3W

concurrent chemoradiation:CT:DDP 25mg/m2 D1+Docetaxel 25mg/m2 D1,Weekly for 5 wks;RT：50Gy/25F/5W(3D-CRT or IMRT).Then,2 cycles consolidation chemotherapy were used:DDP 5mg/m2 D1+Docetaxel75mg/m2 D1, Q3W

intensity modulated radiation therapy in both arms

docetaxel plus cisplatin were used weekly in both arms

concurrent chemotherapy with radiation

xiao zheng, MD

ming chen, PHD

Xiao Zheng, MD

Radiation therapy plus concurrent chemotherapy is now the standard therapy for patients with localized carcinoma of the esophagus selected for nonsurgical treatment. The standard radiation dose is 50-50.4Gy/1.8-2.0Gy/F.All of this were based on 2D radiation technology. Entering new century, 3D-CRT or IMRT has used on esophageal cancer. In China,the recommend radiation dose of concurrent chemoradiation was 60Gy. The study is a clinical phase III, randomized trial to compare the different radiation dose(60Gy vs 50Gy) of concurrent chemoradiation using 3D-CRT or IMRT in patients with unresectable esophageal carcinoma.

Comparable Study of Different Radiation Dose in Esophageal Carcinoma

A Prospective, Randomised Phase 3 Study of High-dose Versus Standard-dose Radiation of Inoperable Esophageal Carcinoma Treated With Concurrent Chemoradiation

Zhejiang Cancer Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Comparable Study of Different Radiation Dose in Esophageal Carcinoma	NCT01937208	Esophageal Carc...	intensity modul... concurrent chem...	18 Years - 70 Years	Zhejiang Cancer Hospital
Comparable Study of Different Radiation Dose in Esophageal Carcinoma	NCT01937208	Esophageal Carc...	intensity modul... concurrent chem...	18 Years - 70 Years	Zhejiang Cancer Hospital

Spots Global Cancer Trial Database for concurrent chemotherapy with radiation