Symptoms and General Pathology

All Conditions

Neoplasms

Skin and Connective Tissue Diseases

Nervous System Diseases

Heart and Blood Diseases

Hemorrhage

Ganglion Cysts

Synovial Cyst

Basal Ganglia Hemorrhage

Cysts

Mucinoses

Connective Tissue Diseases

Cerebrovascular Disorders

Basal Ganglia Diseases

Brain Diseases

Central Nervous System Diseases

Cerebral Hemorrhage

Intracranial Hemorrhages

Vascular Diseases

Coagulants

All Drugs and Chemicals

Fibrinolytic Agents

Hemostatics

Tissue Plasminogen Activator

Stereotactic puncture aspiration to evacuate basal ganglion hematoma with use of thrombolytic agent

Minimally invasive puncture aspiration plus rt-PA

Drugs for symptomatic treatment such as hemostasis and nerve nourishing.

Conservative medical treatment

Spontaneous cerebral hemorrhage is one of the main causes of death and disability all over the world, accounting for 20%-30% of all cerebrovascular diseases. Minimally invasive surgery of cerebral hemorrhage, especially puncture aspiration, can improve early and long-term neurological recovery in patients with cerebral hemorrhage. Until now, no standardized practice for minimally invasive surgery of spontaneous cerebral hemorrhage has been established. Hematoma puncture and drainage based on CT scans without precise localization and personalized approach design, which may lead to poor efficacy and high risk of complications. The investigators' hospital has much experience in treating cerebral hemorrhage with stereotactic puncture and aspiration. So the investigators conduct a prospective multicenter randomized controlled clinical trial across the country to determine the therapeutic effects of puncture aspiration plus thrombolysis treatment for the perioperative and long-term recovery of patients with small hematoma in deep basal ganglia via computerized precision coordinates and personalized approach design.

1. Prospective enrollment of patients with small spontaneous basal ganglia hematoma according to the inclusion and exclusion criteria in 14 major neurosurgical centers across the country to establish a multi-center clinical database of spontaneous small basal ganglia hematoma with data maintenance and update.
2. Random allocation of the patients enrolled into control group (conservative treatment with conventional drugs) or intervention group (minimally invasive puncture aspiration plus rt-PA); long-term follow-up for 6 months to compare the recent and long-term mortality rate, disability rate and related complications of the two groups.

Stereotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation II

Stereotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation II (SOITBE II)

ADL: Activities of Daily Living, ranges from 0-100, a higher ADL score means a better situation.

GCS: Glasgow Coma Scale, ranges from 3-15, a higher GCS score means a better situation.

Huashan Hospital

First Affiliated Hospital of Guangxi Medical University

Southern Medical University, China

China-Japan Friendship Hospital

The First Affiliated Hospital of Anhui Medical University

Second Affiliated Hospital of Xi'an Jiaotong University

The Affiliated Hospital Of Southwest Medical University

Tibet Autonomous Region People's Hospital

The Second Affiliated Hospital of Harbin Medical University

First Affiliated Hospital of Xinjiang Medical University

The Affiliated Hospital of Inner Mongolia Medical University

General Hospital of Ningxia Medical University

Central South University

Second Affiliated Hospital, School of Medicine, Zhejiang University

Spots Global Cancer Trial Database for conservative medical treatment