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breast cancer women with mastectomy high-risk: T3-4 and/or 4 or more axillary nodes involvement postmastectomy hypofractionation radiotherapy of 43.5Gy/15f/3w to the chest wall and supraclavicular nodal region

breast cancer women with mastectomy high-risk with T3-4 and/or 4 or more axillary nodes postmastectomy conventional fractionation radiotherapy of 50Gy/25f/5w to the chest wall and supraclavicular nodal region

radiotherapy of 43.5Gy/15f/3w to the chest wall and supraclavicular nodal region

hypofractionation radiotherapy

conventional fractionation radiotherapy

shu-lian wang, M.D.

Ye-xiong Li, M.D.

The purpose of this study is to compare the efficacy and toxicities of hypofractionation radiotherapy with conventional fractionation radiotherapy in breast cancer patients treated with mastectomy.It is hypothesized that the efficacy and toxicities are similar between the two groups.

Eligible breast cancer patients with mastectomy and axillary dissection are randomized into 2 groups:conventional fractionation radiotherapy of 50 Gy in 25 fractions within 5 weeks to ipsilateral chest wall and supraclavicular nodal region,and hypofractionation radiotherapy of 43.5Gy in 15 fractions within 3 weeks to the same region.

During and after radiotherapy, the patients are followed and the efficacy and toxicities of radiotherapy are evaluated.

A Phase Ⅲ Randomized Clinical Trial of Postmastectomy Hypofractionation Radiotherapy in High-risk Breast Cancer

ipsilateral chest wall, axilla, supraclavicular and internal mammary nodal relapse

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Phase Ⅲ Randomized Clinical Trial of Postmastectomy Hypofractionation Radiotherapy in High-risk Breast Cancer	NCT00793962	Breast Cancer	hypofractionati... conventional fr...	18 Years - 75 Years	ChineseAMS
A Phase Ⅲ Randomized Clinical Trial of Postmastectomy Hypofractionation Radiotherapy in High-risk Breast Cancer	NCT00793962	Breast Cancer	hypofractionati... conventional fr...	18 Years - 75 Years	ChineseAMS

Spots Global Cancer Trial Database for conventional fractionation radiotherapy