Neoplasms

All Conditions

Rare Diseases

Glioblastoma

Astrocytoma

Glioma

Neoplasms, Neuroepithelial

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Glandular and Epithelial

Neoplasms, Nerve Tissue

Neuroepithelioma

The presence of a specific abnormality initially identified on the primary tumor and which can be quantified in the cDNA during the management will allow a better follow-up of the patient.

Correlation between molecular anomalies of the primary tumor and circulating tumor DNA

Glioblastomas (GBM) are rare tumors of poor prognosis and their treatment is based on surgery followed by radiochemotherapy. Clinical and imaging evaluation is not always straightforward: the more or less complete surgery, the pseudo-progression after radiochemotherapy, the radionecrosis, the diagnosis of the relapse and the follow-up under anti-angiogenic can pose problems Clinicians and radiologists. Accessibility to a plasma tumor molecular marker would greatly facilitate the follow-up of these patients.

It is now established for many cancers that circulating tumor DNA (cTNA) has the same molecular abnormalities as those identified in the primary tumor cells. Numerous studies have shown the prognostic value and diagnosis of the exploration of cDNA.

Evaluation of Circulating Tumor DNA as a Theranostic Marker in the Management of Glioblastomas.

Centre Hospitalier Universitaire, Amiens

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of Circulating Tumor DNA as a Theranostic Marker in the Management of Glioblastomas.	NCT03115138	Glioblastoma Molecular Disea...	Correlation bet...	18 Years -	Centre Hospitalier Universitaire, Amiens
Evaluation of Circulating Tumor DNA as a Theranostic Marker in the Management of Glioblastomas.	NCT03115138	Glioblastoma Molecular Disea...	Correlation bet...	18 Years -	Centre Hospitalier Universitaire, Amiens
Evaluation of Circulating Tumor DNA as a Theranostic Marker in the Management of Glioblastomas.	NCT03115138	Glioblastoma Molecular Disea...	Correlation bet...	18 Years -	Centre Hospitalier Universitaire, Amiens

Spots Global Cancer Trial Database for correlation between molecular anomalies of the primary tumor and circulating tumor dna