Skin and Connective Tissue Diseases

All Conditions

Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

Digestive System Diseases

Skin Diseases

Carcinoma, Non-Small-Cell Lung

Carcinoma

Colorectal Neoplasms

Head and Neck Neoplasms

Acne Vulgaris

Exanthema

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

Lung Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

In this arm label, patients will apply the Onco-Rash cream on selected zones (face, neck, thorax,...) twice a day, during 6 weeks.

This arm will be compared to the Onco-Neutral arm, in which the Onco-Neutral cream will be applied on selected zones (face, neck, thorax,...) twice a day, during 6 weeks.

In this arm label, patients will apply the Onco-Neutre cream on selected zones (face, neck, thorax,...) twice a day, during 6 weeks.

Onco-Neutral cream will be used as an experimental comparator to Onco-Rash cream.

This arm will be compared to the Onco-Neutral arm, in which the Onco-Neutral cream will be applied on selected zones (face, neck, thorax,...) twice a day, during 6 weeks.

The cream "Onco-Rash" will be administered topically. The patient will be asked to apply the cream twice a day in the morning and evening for 6 weeks to clean, dry skin on selected target areas of the body, namely: the face, the front of the neck, the front of the chest, the back of the neck and the back of the chest. The product penetrates by gentle massage.

Application of Onco-Rash cream

The cream "Onco-Neutre" will be administered topically. The patient will be asked to apply the cream twice a day in the morning and evening for 6 weeks to clean, dry skin on selected target areas of the body, namely: the face, the front of the neck, the front of the chest, the back of the neck and the back of the chest. The product penetrates by gentle massage.

Application of Onco-Neutre cream

Julien PERON, MD

Anne-Sophie BELMONT

It is important for patients treated with anti-EGFR therapies to get access to cosmetic options to preserve their skin condition during treatment. Anti-EGFR therapies are known to fragilize epidermis and to provoke rashes; which often lead to treatment discontinuation.

The aim of this study is to demonstrate that the Onco-Rash cream is able to preserve skin condition without side effects. Decreasing skin toxicity is expected to improve patients' life and facilitate treatment follow-up.

Evaluation of a Cosmetic Product to Preserve Skin Conditions When Using Anti-EGFR Cancer Therapies

Evaluation of a Cosmetic Product (Onco-Rash) to Preserve Skin Conditions When Using Anti-EGFR Cancer Therapies Which Are Known to Fragilize Epidermis

Measurement of Onco-Rash percentage of failure by counting the number of patients for whom a skin rash with a grade ≥ 2 (NCI-CTCAE scale) will occur between 0-6 weeks after the start of the anti-EGFR treatment. The introduction of an anti-inflammatory, a calming or an antibiotic treatment for acne will also be considered as failure.

Comparison of timing of apparition of grade 1, 2 or ≥ 2 skin eruption between the Onco-Rash arm and the Onco-Neutral arm.

Number of patients for whom a grade 1, 2 or ≥ 2 skin eruption have been reported

Number of patients for whom treatment for acne (anti-inflammatory or antibiotic) has been prescribed

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Evaluation of a Cosmetic Product to Preserve Skin Conditions When Using Anti-EGFR Cancer Therapies	NCT04878692	Carcinoma, Non-... Colorectal Neop... Head and Neck N...	Application of ... Application of ...	18 Years -	Hospices Civils de Lyon
Evaluation of a Cosmetic Product to Preserve Skin Conditions When Using Anti-EGFR Cancer Therapies	NCT04878692	Carcinoma, Non-... Colorectal Neop... Head and Neck N...	Application of ... Application of ...	18 Years -	Hospices Civils de Lyon

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