Spots Global Cancer Trial Database for head and neck neoplasms
Every month we try and update this database with for head and neck neoplasms cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| C-TPF in Patients With Newly Diagnosed Locally Advanced Squamous Cell Carcinoma of the Head and Neck | NCT00402545 | Head and Neck N... | Cetuximab Docetaxel Cisplatin 5-Fluorouracil | 18 Years - | Dana-Farber Cancer Institute | |
| Exercise After Radiation for Head & Neck Cancer | NCT04013178 | Head and Neck N... | Accentuated ecc... Conventional re... | 18 Years - 75 Years | University of Calgary | |
| A Study of SBRT for Squamous Cell Carcinoma of the Head and Neck | NCT04435938 | Head and Neck N... Squamous Cell C... Squamous Skin C... | Stereotactic Bo... | 60 Years - | McMaster University | |
| Normalcy of Food Intake in Head and Neck Cancer Patients | NCT01110980 | Neoplasms, Head... | Swallow therapy... Individual diet... | 18 Years - | Radboud University Medical Center | |
| Nurse-led Exercise Improves Shoulder Pain, Shoulder Disability, and Quality of Life in Head and Neck Cancer | NCT05269342 | Head and Neck C... Cancer of Head ... Head and Neck N... | nurse-led couns... | 20 Years - | Hualien Tzu Chi General Hospital | |
| ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced or Recurrent Head and Neck Carcinoma | NCT03003637 | Immunotherapy Head and Neck N... | Nivolumab Ipilimumab | 18 Years - | The Netherlands Cancer Institute | |
| Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer | NCT00496236 | Head and Neck C... Head and Neck N... | TNFerade biolog... | 18 Years - | GenVec | |
| A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) | NCT04222972 | RET-fusion Non ... Lung Neoplasm Carcinoma, Non-... Respiratory Tra... Thoracic Neopla... Neoplasms by Si... Neoplasms Lung Diseases Respiratory Tra... Carcinoma, Bron... Bronchial Disea... Head and Neck N... Adenocarcinoma Carcinoma Neoplasms by Hi... Neoplasms, Germ... Neoplasms, Nerv... | Pralsetinib Carboplatin Cisplatin Pemetrexed Pembrolizumab Gemcitabine Paclitaxel Nab-Paclitaxel | 18 Years - | Hoffmann-La Roche | |
| Evaluation of Ocoxin®-Viusid® in Advanced Stomach Cancer and Gastric Esophagogastric Junction | NCT03549494 | Stomach Neoplas... Gastrointestina... Digestive Syste... Esophageal Neop... Head and Neck N... Gastrointestina... Digestive Syste... Esophageal Dise... Stomach Disease... Esophagogastric... | Ocoxin-Viusid® | 18 Years - | Catalysis SL | |
| Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer | NCT00496236 | Head and Neck C... Head and Neck N... | TNFerade biolog... | 18 Years - | GenVec | |
| Accuracy and Safety of Coplanar Template Assistance for Head and Neck Biopsies. | NCT05396183 | Head and Neck N... | 18 Years - 85 Years | Peking University Third Hospital | ||
| Effect of Goal-directed Fluid Therapy Using Stroke Volume Variation in Patients Undergoing Free Flap Reconstruction After Head and Neck Cancer Resection | NCT02003066 | General Anesthe... | Standard fluid ... Conservative fl... | 20 Years - 80 Years | Yonsei University | |
| Dose-Response Curve: Interventions to Prevent and Treat Radiodermatitis | NCT02249884 | Radiodermatitis | Urea Dose A Urea Dose B Urea Dose C Chamomile Dose ... Chamomile Dose ... Chamomile Dose ... | 18 Years - | University of Brasilia | |
| Hearing Loss and the Effects of Statin Drugs in People With Head and Neck Squamous Cell Carcinoma Treated With Cisplatin Chemoradiation | NCT03225157 | Head and Neck N... Hearing Disorde... Hyperlipidemia | 18 Years - | National Institutes of Health Clinical Center (CC) | ||
| Image-guided Cryoablation of Head, Neck and Spine Tumors | NCT02085941 | Head and Neck N... Malignant Neopl... | Cryoablation Biopsy | 18 Years - | Dana-Farber Cancer Institute | |
| Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) | NCT02568267 | Breast Cancer Cholangiocarcin... Colorectal Canc... Head and Neck N... Lymphoma, Large... Melanoma Neuroendocrine ... Non-Small Cell ... Ovarian Cancer Pancreatic Canc... Papillary Thyro... Primary Brain T... Renal Cell Carc... Sarcomas Salivary Gland ... Adult Solid Tum... | Entrectinib | 18 Years - | Hoffmann-La Roche | |
| Evaluation the Effects of Herbal Gargle for Chemoradiotherapy-induced Oral Mucositis of Head & Neck Cancer, a Pilot Study. | NCT05341206 | Head and Neck N... Chemoradiothera... Stomatitis and ... | Herbal gargle Normal saline | 20 Years - | Chang Gung Memorial Hospital | |
| Assessing Benefits of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Total Thyroidectomy | NCT05022667 | Thyroid Neoplas... Thyroid Disease... Hypoparathyroid... Endocrine Syste... Endocrine Gland... Neoplasms by Si... Neoplasms Head and Neck N... Parathyroid Dis... | PTeye | 18 Years - | University of Michigan | |
| Leg Function and ADL After ALT Reconstruction for Head and Neck Cancer | NCT02332161 | Free Tissue Fla... Head and Neck N... | surveys, evalua... | 18 Years - | University of Chicago | |
| A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements | NCT03093116 | Locally Advance... Metastatic Soli... | Oral repotrecti... | 12 Years - | Turning Point Therapeutics, Inc. | |
| Gefitinib (Iressa) in Combo With Chemoradiation in Patients With Locally Advanced Head & Neck Cancer | NCT00239304 | Head and Neck N... | Gefitinib Cisplatin Radiotherapy | 18 Years - | AstraZeneca | |
| Prospective, Observational, Real-world Oral Malignant Tumors Study | NCT02395367 | Head and Neck N... Quality of Life Postoperative C... | resection adjuvant radiot... neoadjuvant che... | - | Beijing Stomatological Hospital | |
| Regional Anesthesia Block in Fibula Free Flap Reconstruction | NCT03906838 | Anesthesia, Loc... Surgery Opioid Use Pain, Postopera... Head and Neck N... | Ropivacaine inj... | 18 Years - 100 Years | University of Florida | |
| Biospecimen Procurement for Head and Neck Disorders | NCT03429036 | Hearing Disorde... Oral Mucosal Di... Pharyngeal Neop... Head and Neck N... Laryngeal Disea... | 3 Years - 120 Years | National Institutes of Health Clinical Center (CC) | ||
| Engagement of Patients With Advanced Cancer | NCT02966509 | End of Life Advanced Cancer Lung Neoplasm Gastric Cancer Colon Cancer Glioblastoma Mu... Head and Neck N... Rectum Cancer Melanoma Kidney Cancer Prostate Cancer Testicular Neop... Liver Cancer Cancer of Unkno... | EPAC | 18 Years - | Stanford University | |
| LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy | NCT01345669 | Head and Neck N... | Placebo Afatinib | 18 Years - | Boehringer Ingelheim | |
| Response to Intermittent Pneumatic Compression Therapy in Head and Neck Cancer-Related Lymphedema | NCT02946021 | Head and Neck N... Head and Neck L... Head and Neck C... | Head and neck g... NIRFLI with ICG | 18 Years - | Tactile Medical | |
| Remote Ischemic Preconditioning in Head and Neck Cancer Reconstruction - A Randomized Controlled Trial | NCT02548377 | Head and Neck N... | Remote ischemic... Sham | 18 Years - | Aarhus University Hospital Skejby | |
| The Fibrosis-Lymphedema Continuum in Head and Neck Cancer | NCT01187173 | Head and Neck N... Fibrosis Lymphedema Biomarkers Polymorphism, G... Depression | 21 Years - | Vanderbilt University | ||
| Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole | NCT00038038 | Squamous Cell C... Head and Neck N... Metastases, Neo... | 18F-fluoromison... PET scan | 18 Years - | M.D. Anderson Cancer Center | |
| Radiotherapy Related Skin Toxicity: Mepitel® vs. Standard Care in Patients With Locally Advanced Head-and-Neck Cancer | NCT03047174 | Head and Neck N... | Mepitel® Film Standard Care | 18 Years - 80 Years | University Hospital Schleswig-Holstein | |
| Feasibility Study of Incorporating 18F-FDG-PET Imaging in Radiotherapy for Head and Neck Cancer | NCT00135161 | Head and Neck N... | FDG-PET-based d... | 18 Years - | University Hospital, Ghent | |
| A Trial Comparing Two Modalities of Prophylactic Nutritional Support During Treatment for Head and Neck Cancer | NCT01985438 | Head and Neck N... | percutaneous en... nasogastric tub... | 18 Years - | Shaukat Khanum Memorial Cancer Hospital & Research Centre | |
| Multi-Modality Imaging for Head & Neck Cancer Free Flap Design Assessment | NCT02629029 | Head and Neck N... | Pre-op CTA with... Computed tomogr... | 18 Years - | University Health Network, Toronto | |
| STEREO-POSTOP 01 (PostOperative Hypofractionated Stereotactic Body Radiotherapy ) - GORTEC 2017-03 | NCT03401840 | Head and Neck N... | postoperative h... | 18 Years - | Centre Jean Perrin | |
| Exploration of Tumor Accumulation of BAY94-9392 in Patients With Cancer | NCT01186601 | Neoplasms | PET tracer (BAY... | 18 Years - 90 Years | Life Molecular Imaging SA | |
| First in Human Study of AZD9592 in Solid Tumors | NCT05647122 | Advanced Solid ... Carcinoma Non-s... Head and Neck N... Colorectal Neop... | AZD9592 Osimertinib 5-Fluorouracil ... Leucovorin Bevacizumab | 18 Years - | AstraZeneca | |
| Pharmacokinetic Study of Porfiromycin in Head and Neck Cancer and Other Cancer Patients With Solid Tumors | NCT02209701 | Head and Neck N... | Porfiromycin | 18 Years - | Boehringer Ingelheim | |
| Trial to Determine Optimal Phase II Dose of the Oral Dual CAIX Inhibitor/ Radiosensitizer | NCT02216669 | Solid Tumors Head and Neck N... | DTP348 | 18 Years - | Maastricht Radiation Oncology | |
| A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors | NCT06237881 | Advanced Solid ... Melanoma Lung Neoplasms Head and Neck N... | KSQ-001EX Interleukin-2 Cyclophosphamid... Fludarabine | 18 Years - 70 Years | M.D. Anderson Cancer Center | |
| Tabelecleucel in Combination With Pembrolizumab in Subjects With Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC) | NCT03769467 | Nasopharyngeal ... Nasopharyngeal ... Epstein-Barr Vi... Epstein-Barr Vi... Epstein-Barr Vi... | tabelecleucel pembrolizumab | 12 Years - | Atara Biotherapeutics | |
| EMST in Patients Undergoing CRT for HNCA | NCT03916809 | Head and Neck N... Deglutition Dis... | EMST | 18 Years - | University of Wisconsin, Milwaukee | |
| Image Guided Adaptive Radiotherapy in the Head-and-neck Region | NCT02545322 | Head and Neck N... | Follow-up CT sc... | 18 Years - 80 Years | Medical University of Graz | |
| Tumor Hypoxia of Head-and-neck Cancer Underwent Radiation Therapy Measured With F-18-FMISO | NCT00180180 | Head and Neck N... | 18 Years - 70 Years | Technische Universität Dresden | ||
| Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors | NCT02975739 | Radioisotopes Head and Neck N... | Holmium-166 (po... | 18 Years - | UMC Utrecht | |
| Tranexamic Acid and Head and Neck Surgery Patients | NCT00308880 | Head and Neck N... | Transamin | 20 Years - 80 Years | Taichung Veterans General Hospital | |
| Heavy Strength Training in Head and Neck Cancer Survivors | NCT06289049 | Head and Neck N... Head and Neck C... Head and Neck S... Head and Neck C... | Experimental | 18 Years - | University of Alberta | |
| Robot Assisted Supraomohyoid Neck Dissection Via Retroauricular Approach | NCT01488669 | Head and Neck N... | robot assisted ... Conventional ne... | 18 Years - 80 Years | Yonsei University | |
| Needs Assessment Tool Integrated in Clinical Practice of Head and Neck Cancer Rehabilitation | NCT03443258 | Head and Neck N... | Needs assesment... | 16 Years - | Rigshospitalet, Denmark | |
| Needs Assessment Tool Integrated in Clinical Practice of Head and Neck Cancer Rehabilitation | NCT03443258 | Head and Neck N... | Needs assesment... | 16 Years - | Rigshospitalet, Denmark | |
| A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001) | NCT03157128 | Non-Small Cell ... Medullary Thyro... Colon Cancer Any Solid Tumor | LOXO-292 | 12 Years - | Eli Lilly and Company | |
| A Biomarker-driven, Open Label, Single Arm, Multicentre Phase II Study of Abemaciclib in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Who Failed to Platinum-based Therapy | NCT03356587 | HNSCC Head and Neck N... | Abemaciclib | 20 Years - | Seoul National University Hospital | |
| Concomitant Radiation and Cisplatin With and Without Tirapazamine in Treatment of Advanced Head and Neck Cancer | NCT00094081 | Head and Neck N... | tirapazamine (S... cisplatin Radiation Thera... | 18 Years - | Sanofi | |
| Simultaneous Care in Recurrent and/or Metastatic Head and Neck Cancer: the SupCare Study | NCT06347185 | Head and Neck N... | Early palliativ... Palliative care... | 18 Years - | European Organisation for Research and Treatment of Cancer - EORTC | |
| A Pilot Study of the Use of the DaVinci Robotic System for Otorhinolaryngology-Head and Neck Surgery | NCT00627562 | Head and Neck N... | robot assisted ... | 18 Years - | Montefiore Medical Center | |
| De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca | NCT01530997 | Carcinoma, Squa... Head and Neck N... Oropharyngeal N... | Intensity Modul... Cisplatin Limited surgica... | 18 Years - | UNC Lineberger Comprehensive Cancer Center | |
| Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy | NCT05308732 | Head and Neck N... Mucositis Oral Radiotherapy; C... | Copaiba | 18 Years - | Instituto Nacional de Cancer, Brazil | |
| A Prospective Randomized Trial of Capecitabine Treatment in Patients With HNSCC | NCT03678649 | Head and Neck N... | Capecitabine | 18 Years - 65 Years | Zhejiang Cancer Hospital | |
| ZD1839 (IRESSA™) in Combination With Docetaxel & Cisplatin in Subjects With Metastatic Head & Neck Cancer | NCT00242762 | Head and Neck C... | ZD1839 (IRESSA™... Docetaxel Cisplatin | 18 Years - 70 Years | AstraZeneca | |
| BIBW 2992 (Afatinib) in Head & Neck Cancer | NCT00514943 | Head and Neck N... Carcinoma, Squa... | BIBW 2992 Cetuximab | 18 Years - | Boehringer Ingelheim | |
| F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients | NCT00721799 | Mouth Neoplasms Oropharyngeal N... Laryngeal Neopl... Head and Neck N... | 18F-Fluorothymi... | 18 Years - | University of Iowa | |
| Accuracy and Safety of Coplanar Template Assistance for Head and Neck Biopsies. | NCT05396183 | Head and Neck N... | 18 Years - 85 Years | Peking University Third Hospital | ||
| Cox-2 Inhibition in Radiation-induced Oral Mucositis | NCT00698204 | Oral Mucositis | celecoxib placebo | 18 Years - 75 Years | UConn Health | |
| Pharmacokinetic Study of Porfiromycin in Head and Neck Cancer and Other Cancer Patients With Solid Tumors | NCT02209701 | Head and Neck N... | Porfiromycin | 18 Years - | Boehringer Ingelheim | |
| EMST and Swallowing in Long-Term Survivors of HNCA | NCT03975465 | Head and Neck N... Deglutition Dis... | Expiratory Musc... Pharyngeal Musc... | 18 Years - | University of Wisconsin, Milwaukee | |
| H&N Cancer; Survivorship and Late Effects | NCT04758026 | Head and Neck N... Survivorship | 18 Years - | Oslo University Hospital | ||
| Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors | NCT02975739 | Radioisotopes Head and Neck N... | Holmium-166 (po... | 18 Years - | UMC Utrecht | |
| Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis | NCT03540953 | Esophageal Sten... Deglutition Dis... Head and Neck N... Esophageal Neop... | Endoscopic inje... | 18 Years - | Instituto do Cancer do Estado de São Paulo | |
| Trial to Determine Optimal Phase II Dose of the Oral Dual CAIX Inhibitor/ Radiosensitizer | NCT02216669 | Solid Tumors Head and Neck N... | DTP348 | 18 Years - | Maastricht Radiation Oncology | |
| A Study for Participants With Recurrent or Metastatic Squamous Cell Head and Neck Cancer | NCT01087970 | Head and Neck N... | Pemetrexed Cetuximab Carboplatin Cisplatin | 18 Years - | Eli Lilly and Company | |
| Simultaneous Care in Recurrent and/or Metastatic Head and Neck Cancer: the SupCare Study | NCT06347185 | Head and Neck N... | Early palliativ... Palliative care... | 18 Years - | European Organisation for Research and Treatment of Cancer - EORTC | |
| Induction Chemotherapy With ACF Followed by Chemoradiation Therapy for Adv. Head & Neck Cancer | NCT01566435 | Head and Neck N... | paclitaxel albu... Cisplatin Fluorouracil Intensity modul... Cetuximab Quality-of-life... | 18 Years - | Washington University School of Medicine | |
| Does Tranexamic Acid Administration Reduce Blood Loss During Head and Neck Surgery? | NCT00147862 | Head and Neck N... | Tranexamic Acid | - | Tata Memorial Hospital | |
| Preventive Physical Activity Intervention in Head and Neck Cancer | NCT05432297 | Head and Neck N... Physical Inacti... | Preventive phys... | 18 Years - | Sahlgrenska University Hospital, Sweden | |
| Study of Xevinapant With Radiation and Chemotherapy for Patients With Head and Neck Cancer | NCT06110195 | Head and Neck C... Head and Neck N... Squamous Cell C... | Xevinapant Carboplatin Paclitaxel Radiation Thera... | 18 Years - | University of Chicago | |
| Prospective, Post Marketing Surveillance Study On Erbitux® (Cetuximab) in Patients With Locally Advanced or Recurrent and/or Metastatic Squamous Cell Cancer of the Head and Neck in Korea | NCT01075828 | Head and Neck C... | Cetuximab | - | Merck KGaA, Darmstadt, Germany | |
| Regional Anesthesia Block in Fibula Free Flap Reconstruction | NCT03906838 | Anesthesia, Loc... Surgery Opioid Use Pain, Postopera... Head and Neck N... | Ropivacaine inj... | 18 Years - 100 Years | University of Florida | |
| Molecular and Genomic Profiling of Head and Neck Tumors | NCT00200486 | Head and Neck N... | - | Montefiore Medical Center | ||
| A Biomarker-driven, Open Label, Single Arm, Multicentre Phase II Study of Abemaciclib in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Who Failed to Platinum-based Therapy | NCT03356587 | HNSCC Head and Neck N... | Abemaciclib | 20 Years - | Seoul National University Hospital | |
| Pilot Study for Locally Advanced Head and Neck Cancer | NCT01262859 | Head and Neck N... | bevacizumab | 18 Years - | University of Pittsburgh |
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